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Differential Perceptual-Spatial Impairment in Huntington's and Alzheimer's Dementias

Differential Perceptual-Spatial Impairment in Huntington's and Alzheimer's Dementias Abstract • Because the severity of memory disorders exhibited by neuropsychiatric patients overshadows other cognitive deficiencies, we explored the visuoperceptual and constructive abilities of patients with Alzheimer's (AD) or Huntington's (HD) disease. The tasks assessed directional sense with reference to egocentric space, as well as visuodiscriminative and constructive skills of patients and matched controls. A double dissociation was found: the performance of patients with AD was found to be significantly impaired on tasks involving extrapersonal perception and construction but not on the test of egocentric space. In contrast, visuoconstructive performance by patients with HD was not significantly impaired, while salient deficits were apparent when manipulation of personal space was required. These differential patterns of defects may have been aligned with neuropathologic changes in different cortical and subcortical structures, respectively, in patients with AD and HD. References 1. Miller E: The nature of the cognitive deficit in senile dementia , in Miller NE, Cohen GD (eds): Aging . New York, Raven Press, 1981, vol 15: Clinical Aspects of Alzheimer's Disease and Senile Dementia, pp 103-120. 2. Bruyn GW, Bots GTAM, et al: Huntington's chorea: Current neuropathological status , in Chase TN, Wexler NS, Barbeau A (eds): Advances In Neurology . New York, Raven Press, 1979, vol 23: Huntington's Disease, pp 83-93. 3. Brun A, Gustafson L: Distribution of cerebral degeneration in Alzheimer's disease: A clinico-pathological study . Arch Psychiatr Nervenkr 1976; 223:15-33.Crossref 4. Money J, Alexander D, Walker HT: A Standardized Road-Map Test of Direction Sense . Baltimore, Johns Hopkins Press, 1965. 5. Butters N, Soeldner C, Fedio P: Comparison of parietal and frontal lobe spatial deficits in man: Extrapersonal vs personal (egocentric) space . Percept Mot Skills 1972;34:27-34.Crossref 6. Potegal M: A note on spatial-motor deficits in patients with Huntington's disease: A test of a hypothesis . Neuropsychologia 1971;9:233-235.Crossref 7. Lishman WA: Organic Psychiatry: The Psychological Consequences of Cerebral Disorder . Oxford, England, Blackwell Scientific Publications, 1978. 8. Rey A: L'examen psychologique dans les cas d'encephalopathie traumatique . Arch Psychol 1941; 28:286-340. 9. Osterrieth P: Le test de copie d'une figure complexe . Arch Psychol 1944;30:206-356. 10. Mosaic Comparisons Test: Comparative Guidelines and Placement Programs. Princeton, NJ, College Entrance Examination Board, Educational Testing Service, 1972. 11. Milner B, Teuber HL: Alterations of perception and memory in man: Reflections on methods , in Weiskrantz L (ed): Analysis of Behavior . New York, Harper & Row Publishers Inc, 1968, pp 268-275. 12. Kirk RN: Experimental Design: Procedures for the Behavioral Sciences . Belmont, Calif, Brooks/Cole Publishing Co, 1968. 13. Scheffe H: The Analysis of Variance . New York, John Wiley & Sons Inc, 1959. 14. Geisser S, Greenhouse SW: An extension of Box's results on the use of the F-distribution in multivariate analysis . Ann Math Stat 1958; 29:885-891.Crossref 15. Fedio P, Cox C, Neophytides A, et al: Neuropsychological profile of Huntington's disease: Patients and those at risk , in Chase TN, Wexler NS, Barbeau A (eds): Advances in Neurology . New York, Raven Press, 1979, vol 23: Huntington's Disease, pp 239-255. 16. Semmes J, Weinstein S, Ghent L, et al: Correlates of impaired orientation in personal and extra-personal space . Brain 1963;86:747-772.Crossref 17. Money J: A Standardized Road-Map Test of Directional Sense . San Rafael, Calif, Academic Therapy Publications, 1976. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Differential Perceptual-Spatial Impairment in Huntington's and Alzheimer's Dementias

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1984.04050210071017
Publisher site
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Abstract

Abstract • Because the severity of memory disorders exhibited by neuropsychiatric patients overshadows other cognitive deficiencies, we explored the visuoperceptual and constructive abilities of patients with Alzheimer's (AD) or Huntington's (HD) disease. The tasks assessed directional sense with reference to egocentric space, as well as visuodiscriminative and constructive skills of patients and matched controls. A double dissociation was found: the performance of patients with AD was found to be significantly impaired on tasks involving extrapersonal perception and construction but not on the test of egocentric space. In contrast, visuoconstructive performance by patients with HD was not significantly impaired, while salient deficits were apparent when manipulation of personal space was required. These differential patterns of defects may have been aligned with neuropathologic changes in different cortical and subcortical structures, respectively, in patients with AD and HD. References 1. Miller E: The nature of the cognitive deficit in senile dementia , in Miller NE, Cohen GD (eds): Aging . New York, Raven Press, 1981, vol 15: Clinical Aspects of Alzheimer's Disease and Senile Dementia, pp 103-120. 2. Bruyn GW, Bots GTAM, et al: Huntington's chorea: Current neuropathological status , in Chase TN, Wexler NS, Barbeau A (eds): Advances In Neurology . New York, Raven Press, 1979, vol 23: Huntington's Disease, pp 83-93. 3. Brun A, Gustafson L: Distribution of cerebral degeneration in Alzheimer's disease: A clinico-pathological study . Arch Psychiatr Nervenkr 1976; 223:15-33.Crossref 4. Money J, Alexander D, Walker HT: A Standardized Road-Map Test of Direction Sense . Baltimore, Johns Hopkins Press, 1965. 5. Butters N, Soeldner C, Fedio P: Comparison of parietal and frontal lobe spatial deficits in man: Extrapersonal vs personal (egocentric) space . Percept Mot Skills 1972;34:27-34.Crossref 6. Potegal M: A note on spatial-motor deficits in patients with Huntington's disease: A test of a hypothesis . Neuropsychologia 1971;9:233-235.Crossref 7. Lishman WA: Organic Psychiatry: The Psychological Consequences of Cerebral Disorder . Oxford, England, Blackwell Scientific Publications, 1978. 8. Rey A: L'examen psychologique dans les cas d'encephalopathie traumatique . Arch Psychol 1941; 28:286-340. 9. Osterrieth P: Le test de copie d'une figure complexe . Arch Psychol 1944;30:206-356. 10. Mosaic Comparisons Test: Comparative Guidelines and Placement Programs. Princeton, NJ, College Entrance Examination Board, Educational Testing Service, 1972. 11. Milner B, Teuber HL: Alterations of perception and memory in man: Reflections on methods , in Weiskrantz L (ed): Analysis of Behavior . New York, Harper & Row Publishers Inc, 1968, pp 268-275. 12. Kirk RN: Experimental Design: Procedures for the Behavioral Sciences . Belmont, Calif, Brooks/Cole Publishing Co, 1968. 13. Scheffe H: The Analysis of Variance . New York, John Wiley & Sons Inc, 1959. 14. Geisser S, Greenhouse SW: An extension of Box's results on the use of the F-distribution in multivariate analysis . Ann Math Stat 1958; 29:885-891.Crossref 15. Fedio P, Cox C, Neophytides A, et al: Neuropsychological profile of Huntington's disease: Patients and those at risk , in Chase TN, Wexler NS, Barbeau A (eds): Advances in Neurology . New York, Raven Press, 1979, vol 23: Huntington's Disease, pp 239-255. 16. Semmes J, Weinstein S, Ghent L, et al: Correlates of impaired orientation in personal and extra-personal space . Brain 1963;86:747-772.Crossref 17. Money J: A Standardized Road-Map Test of Directional Sense . San Rafael, Calif, Academic Therapy Publications, 1976.

Journal

Archives of Neurology – American Medical Association

Published: Oct 1, 1984

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