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Lithium Salt Intoxication and Neurologic Sequelae

Lithium Salt Intoxication and Neurologic Sequelae Abstract To the Editor. —I wish to point out some important omissions in the article on "Persisting Neurologic Sequelae of Lithium Carbonate Therapy" by Donaldson and Cuningham.1 The article makes no mention of the similarity of their two cases to the neuroleptic malignant syndrome that is characterized by altered consciousness, hyperthermia, autonomic hypersensitivity, and severe rigidity.2While the neuroleptic malignant syndrome is not generally associated with persistent neurologic deficit, Spring and Frankel3 have described a patient treated with haloperidol and lithium carbonate in whom a persistent dyskinesia resulted. This case is not cited in the review of the literature by Donaldson and Cuningham. Spring and Frankel hypothesize that neuroleptic-lithium carbonate combinations lead to a form of neuroleptic malignant syndrome with permanent neurologic damage. Nine of the 17 patients cited in the article by Donaldson and Cuningham were treated with neuroleptic-lithium carbonate combinations.The article by Donaldson and Cuningham has been widely References 1. Donaldson IM, Cuningham J: Persisting neurologic sequelae of lithium carbonate therapy . Arch Neurol 1983;40:747-751.Crossref 2. Caroff SN: The neuroleptic malignant syndrome . J Clin Psychiatry 1980;41:79-83. 3. Spring G, Frankel M: New data on lithium and haloperidol incompatibility . Am J Psychiatry 1981;138:818-821. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Lithium Salt Intoxication and Neurologic Sequelae

Archives of Neurology , Volume 41 (9) – Sep 1, 1984

Lithium Salt Intoxication and Neurologic Sequelae

Abstract

Abstract To the Editor. —I wish to point out some important omissions in the article on "Persisting Neurologic Sequelae of Lithium Carbonate Therapy" by Donaldson and Cuningham.1 The article makes no mention of the similarity of their two cases to the neuroleptic malignant syndrome that is characterized by altered consciousness, hyperthermia, autonomic hypersensitivity, and severe rigidity.2While the neuroleptic malignant syndrome is not generally associated with persistent...
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1984.04050200018007
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —I wish to point out some important omissions in the article on "Persisting Neurologic Sequelae of Lithium Carbonate Therapy" by Donaldson and Cuningham.1 The article makes no mention of the similarity of their two cases to the neuroleptic malignant syndrome that is characterized by altered consciousness, hyperthermia, autonomic hypersensitivity, and severe rigidity.2While the neuroleptic malignant syndrome is not generally associated with persistent neurologic deficit, Spring and Frankel3 have described a patient treated with haloperidol and lithium carbonate in whom a persistent dyskinesia resulted. This case is not cited in the review of the literature by Donaldson and Cuningham. Spring and Frankel hypothesize that neuroleptic-lithium carbonate combinations lead to a form of neuroleptic malignant syndrome with permanent neurologic damage. Nine of the 17 patients cited in the article by Donaldson and Cuningham were treated with neuroleptic-lithium carbonate combinations.The article by Donaldson and Cuningham has been widely References 1. Donaldson IM, Cuningham J: Persisting neurologic sequelae of lithium carbonate therapy . Arch Neurol 1983;40:747-751.Crossref 2. Caroff SN: The neuroleptic malignant syndrome . J Clin Psychiatry 1980;41:79-83. 3. Spring G, Frankel M: New data on lithium and haloperidol incompatibility . Am J Psychiatry 1981;138:818-821.

Journal

Archives of NeurologyAmerican Medical Association

Published: Sep 1, 1984

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