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Effect of Baclofen on Seizure Frequency

Effect of Baclofen on Seizure Frequency Abstract To the Editor —The conclusion of Terrence et al1 that baclofen in usual therapeutic doses does not seem to be epileptogenic may be based on chance observations. The epilepsy of their six controlled patients usually had a good spontaneous prognosis and was not suitable for pharmacologic treatment. One of these six patients showed a major change in seizure frequency concurrent with baclofen administration, yet previous monthly variation of seizure frequency was not described, making interpretation difficult. Furthermore, serum concentrations of the drugs were not available.The authors' data argued neither against an epileptogenic nor for an anticonvulsant action of baclofen. It may be remembered, however, that several presumably or definitely seizure-free patients were described who had epileptic phenomena while receiving baclofen. One patient had a generalized tonic-clonic seizure,2 and two had myoclonia in the recovery phase after baclofen overdose induced a coma.3,4 An epileptic stupor with continuous References 1. Terrence CF, Fromm GH, Roussan MS: Baclofen: Its effect on seizure frequency . Arch Neurol 1983;40:28-29.Crossref 2. Seyfert S, Kraft D, Wagner K: Baclofendosis bei Haemodialyse und Niereninsuffizienz . Nervenarzt 1981;52:616-617. 3. Paulson GW: Overdose of Lioresal . Neurology 1976;26:1105-1106.Crossref 4. Laplatte G, Haegy JM, Faller JP: Tentative d'autolyse au baclofene . Nouv Presse Med 1980;9:2579. 5. Jequier M: Discussion , in Birkmayer W (ed): Spasticity: A topical survey . Bern, Switzerland, Hans Huber Publishers, 1972, pp 203-204. 6. Seyfert S, Straschill M: Elektroenzephalographische Veränderungen unter Baclofen . EEG EMG 1983;13:161-166. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Effect of Baclofen on Seizure Frequency

Archives of Neurology , Volume 41 (2) – Feb 1, 1984

Effect of Baclofen on Seizure Frequency

Abstract

Abstract To the Editor —The conclusion of Terrence et al1 that baclofen in usual therapeutic doses does not seem to be epileptogenic may be based on chance observations. The epilepsy of their six controlled patients usually had a good spontaneous prognosis and was not suitable for pharmacologic treatment. One of these six patients showed a major change in seizure frequency concurrent with baclofen administration, yet previous monthly variation of seizure frequency was not described,...
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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1984.04050140032005
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor —The conclusion of Terrence et al1 that baclofen in usual therapeutic doses does not seem to be epileptogenic may be based on chance observations. The epilepsy of their six controlled patients usually had a good spontaneous prognosis and was not suitable for pharmacologic treatment. One of these six patients showed a major change in seizure frequency concurrent with baclofen administration, yet previous monthly variation of seizure frequency was not described, making interpretation difficult. Furthermore, serum concentrations of the drugs were not available.The authors' data argued neither against an epileptogenic nor for an anticonvulsant action of baclofen. It may be remembered, however, that several presumably or definitely seizure-free patients were described who had epileptic phenomena while receiving baclofen. One patient had a generalized tonic-clonic seizure,2 and two had myoclonia in the recovery phase after baclofen overdose induced a coma.3,4 An epileptic stupor with continuous References 1. Terrence CF, Fromm GH, Roussan MS: Baclofen: Its effect on seizure frequency . Arch Neurol 1983;40:28-29.Crossref 2. Seyfert S, Kraft D, Wagner K: Baclofendosis bei Haemodialyse und Niereninsuffizienz . Nervenarzt 1981;52:616-617. 3. Paulson GW: Overdose of Lioresal . Neurology 1976;26:1105-1106.Crossref 4. Laplatte G, Haegy JM, Faller JP: Tentative d'autolyse au baclofene . Nouv Presse Med 1980;9:2579. 5. Jequier M: Discussion , in Birkmayer W (ed): Spasticity: A topical survey . Bern, Switzerland, Hans Huber Publishers, 1972, pp 203-204. 6. Seyfert S, Straschill M: Elektroenzephalographische Veränderungen unter Baclofen . EEG EMG 1983;13:161-166.

Journal

Archives of NeurologyAmerican Medical Association

Published: Feb 1, 1984

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