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Patterns of Muscle Fiber-Type Disproportion in Hypotonic Infants

Patterns of Muscle Fiber-Type Disproportion in Hypotonic Infants Abstract • We studied the histochemical characteristics of muscle in five hypotonic infants. A number of different patterns of disproportion in the sizes and numbers of type 1 and type 2 fibers were found. In three cases, type 1 fibers were smaller than type 2 fibers and type 2b or 2c fibers were largest. In one case, type 2 fibers were smaller than type 1 fibers and were reduced in number, while in a case of Prader-Willi syndrome there was a pre-ponderance of type 2 fibers that were smaller than type 1 fibers. Type 2c fibers were increased in number in all but one case. We postulate that these various patterns of fiber-type disproportion are the result of altered neural influences leading to impaired maturation of type 1 or type 2 motor units. References 1. Gardner-Medwin D, Tizard JPM: Neuro-muscular disorders in infancy and early childhood , in Walton JN (ed): Disorders of Voluntary Muscle , ed 4. Edinburgh, Churchill Livingstone, 1981, pp 625-663. 2. Brooke MH, Engel WK: The histographic analysis of human muscle biopsies with regard to fiber type: IV. Children's biopsies . Neurology 1969;19:591-605.Crossref 3. Brooke MH: Congenital fibre type disproportion , in Kakulas BA (ed): Clinical Studies in Myology . Amsterdam, Excerpta Medica, 1973, pp 147-159. 4. Fardeau M, Harpey JP, Caille B: Disproportion congenitale des differents types de fiber musculaire avec petitesse relative des fibres de type 1 . Rev Neurol 1975;131:745-766. 5. Lenard HG, Goebel HH: Congenital fibre type disproportion . Neuropaediatrie 1975;6:220-231.Crossref 6. Curless RG, Nelson MB: Congenital fiber type disproportion in identical twins . Ann Neurol 1977;2:455-459.Crossref 7. Eisler T, Wilson JH: Muscle fiber-type disproportion: Report of a family with symptomatic and asymptomatic members . Arch Neurol 1978; 35:823-826.Crossref 8. Berger M, Schroder JM, Gibbels E, et al: Fasertypendisproportion, eine Form der sogenannten kongenitalen nichtprogressiven Myopathien . Fortschr Neurol Psychiatr 1979;47:466-478. 9. Cavanagh NPC, Lake BD, McMeniman P: Congenital fiber type disproportion myopathy . Arch Dis Child 1979;54:735-743.Crossref 10. Clancy RR, Kelts KA, Oehlert JW: Clinical variability in congenital fiber type disproportion . J Neurol Sci 1980;46:257-266.Crossref 11. Martin JJ, Clara R, Ceuterick C, et al: Is congenital fibre type disproportion a true myopathy? Acta Neurol Belg 1976;76:335-344. 12. Brooke MH, Carroll JE, Ringel SP: Congenital hypotonia revisited . Muscle Nerve 1979;2:84-100.Crossref 13. Argov Z, Gardner-Medwin D, Johnson MA, et al: Congenital myotonic dystrophy: Fiber type abnormalities in two cases . Arch Neurol 1980; 37:693-696.Crossref 14. Dehkharghani F, Sarnat HB, Brewster MA, et al: Congenital muscle fiber-type disproportion in Krabbe's leukodystrophy . Arch Neurol 1981;38:585-587.Crossref 15. Pearse AGE: Principles of oxidorectase histochemistry , in Pearse AGE (ed): Histochemistry Theoretical and Applied . Edinburgh, Churchill Livingstone, 1972, vol 2, pp 880-920. 16. Brooke MH, Kaiser KK: Muscle fiber types: How many and what kind? Arch Neurol 1970;23:369-379.Crossref 17. Song SK, Shimada N, Anderson PJ: Orthogonal diameters in the analysis of muscle fibre size and form . Nature 1963;200:1220-1221.Crossref 18. Colling-Saltin A: Enzyme histochemistry on skeletal muscle of the human fetus . J Neurol Sci 1978;39:169-185.Crossref 19. Farkas-Bargeton E, Aicardi J, Arsenio-Nunes ML, et al: Delay in the maturation of muscle fibers in infants with congenital hypotonia . J Neurol Sci 1978;39:17-29.Crossref 20. Schloon H, Schottmann J, Lenard HG, et al: The development of skeletal muscles in premature infants . Eur J Pediatr 1979;131:49-60.Crossref 21. Farkas-Bargeton E, Dibler MF, Arsenio-Nunes ML, et al: Etude de la maturation histochimique quantitative et ultrastructurale du muscle foetal humain . J Neurol Sci 1974;31:245-259.Crossref 22. Kinoshita M, Satoyoshi E, Kumagai M: Familial type 1 fiber atrophy . J Neurol Sci 1975;25:11-17.Crossref 23. Fardeau M: Congenital myopathies , in Mastaglia FL, Walton JN (eds): Skeletal Muscle Pathology . Edinburgh, Churchill Livingstone, 1982, pp 161-203. 24. Curless RG, Nelson MB, Brimmer F: Histological patterns of muscle in infants with developmental brain abnormalities . Dev Med Child Neurol 1978;20:159-166.Crossref 25. Dubowitz V: Muscle Disorders in Childhood . London, WB Saunders Co, 1978. 26. Afifi AK, Zellweger H: Pathology of muscular hypotonia in the Prader-Willi syndrome light and electron microscopic study . J Neurol Sci 1969;9:49-61.Crossref 27. Matsuoko Y, Gubbay SS, Kakulas BA: A new myopathy with type II muscle fiber hypoplasia . Clin Exp Neurol 1974;11:155-159. 28. Dubrovsky A, Taratuto AL, Martino R: Distal spinal muscular atrophy and ophthalmoparesis: A case with selective type 2 fiber hypotrophy . Arch Neurol 1981;38:594-596.Crossref 29. Fenichel GM: Abnormalities of skeletal muscle maturation in brain damaged children: A histochemical study . Dev Med Child Neurol 1967;9:419-426.Crossref 30. Karpati G, Engel WK: Correlative histochemical study of skeletal muscle after suprasegmental denervation, peripheral nerve section and skeletal fixation . Neurology 1968;18:681-692.Crossref 31. Dubowitz V: Cross-innervated mammalian skeletal muscle: Histochemical, physiological and biochemical observation . J Physiol 1967; 193:481-496. 32. Karpati G, Engel WK: Transformation of the histochemical profile of skeletal muscle by 'foreign' innervation . Nature 1967:215:1509-1510.Crossref 33. Romanul FCA, Sreter FA, Salmons S, et al: The effects of a changed pattern of activity on histochemical characteristics of muscle fibers , in Milhorat AT (ed): Exploratory Concepts in Muscular Dystrophy . Amsterdam, Excerpta Medica, 1974, pp 344-348. 34. Munsat TL, McNeal D, Waters R: Effects of nerve stimulation on human muscle . Arch Neurol 1976;33:608-616.Crossref 35. Salmons S, Sereter FA: Significance of impulse activity in the transformation of skeletal muscle type . Nature 1976;263:30-34.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Patterns of Muscle Fiber-Type Disproportion in Hypotonic Infants

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1984.04050130059023
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Abstract

Abstract • We studied the histochemical characteristics of muscle in five hypotonic infants. A number of different patterns of disproportion in the sizes and numbers of type 1 and type 2 fibers were found. In three cases, type 1 fibers were smaller than type 2 fibers and type 2b or 2c fibers were largest. In one case, type 2 fibers were smaller than type 1 fibers and were reduced in number, while in a case of Prader-Willi syndrome there was a pre-ponderance of type 2 fibers that were smaller than type 1 fibers. Type 2c fibers were increased in number in all but one case. We postulate that these various patterns of fiber-type disproportion are the result of altered neural influences leading to impaired maturation of type 1 or type 2 motor units. References 1. Gardner-Medwin D, Tizard JPM: Neuro-muscular disorders in infancy and early childhood , in Walton JN (ed): Disorders of Voluntary Muscle , ed 4. Edinburgh, Churchill Livingstone, 1981, pp 625-663. 2. Brooke MH, Engel WK: The histographic analysis of human muscle biopsies with regard to fiber type: IV. Children's biopsies . Neurology 1969;19:591-605.Crossref 3. Brooke MH: Congenital fibre type disproportion , in Kakulas BA (ed): Clinical Studies in Myology . Amsterdam, Excerpta Medica, 1973, pp 147-159. 4. Fardeau M, Harpey JP, Caille B: Disproportion congenitale des differents types de fiber musculaire avec petitesse relative des fibres de type 1 . Rev Neurol 1975;131:745-766. 5. Lenard HG, Goebel HH: Congenital fibre type disproportion . Neuropaediatrie 1975;6:220-231.Crossref 6. Curless RG, Nelson MB: Congenital fiber type disproportion in identical twins . Ann Neurol 1977;2:455-459.Crossref 7. Eisler T, Wilson JH: Muscle fiber-type disproportion: Report of a family with symptomatic and asymptomatic members . Arch Neurol 1978; 35:823-826.Crossref 8. Berger M, Schroder JM, Gibbels E, et al: Fasertypendisproportion, eine Form der sogenannten kongenitalen nichtprogressiven Myopathien . Fortschr Neurol Psychiatr 1979;47:466-478. 9. Cavanagh NPC, Lake BD, McMeniman P: Congenital fiber type disproportion myopathy . Arch Dis Child 1979;54:735-743.Crossref 10. Clancy RR, Kelts KA, Oehlert JW: Clinical variability in congenital fiber type disproportion . J Neurol Sci 1980;46:257-266.Crossref 11. Martin JJ, Clara R, Ceuterick C, et al: Is congenital fibre type disproportion a true myopathy? Acta Neurol Belg 1976;76:335-344. 12. Brooke MH, Carroll JE, Ringel SP: Congenital hypotonia revisited . Muscle Nerve 1979;2:84-100.Crossref 13. Argov Z, Gardner-Medwin D, Johnson MA, et al: Congenital myotonic dystrophy: Fiber type abnormalities in two cases . Arch Neurol 1980; 37:693-696.Crossref 14. Dehkharghani F, Sarnat HB, Brewster MA, et al: Congenital muscle fiber-type disproportion in Krabbe's leukodystrophy . Arch Neurol 1981;38:585-587.Crossref 15. Pearse AGE: Principles of oxidorectase histochemistry , in Pearse AGE (ed): Histochemistry Theoretical and Applied . Edinburgh, Churchill Livingstone, 1972, vol 2, pp 880-920. 16. Brooke MH, Kaiser KK: Muscle fiber types: How many and what kind? Arch Neurol 1970;23:369-379.Crossref 17. Song SK, Shimada N, Anderson PJ: Orthogonal diameters in the analysis of muscle fibre size and form . Nature 1963;200:1220-1221.Crossref 18. Colling-Saltin A: Enzyme histochemistry on skeletal muscle of the human fetus . J Neurol Sci 1978;39:169-185.Crossref 19. Farkas-Bargeton E, Aicardi J, Arsenio-Nunes ML, et al: Delay in the maturation of muscle fibers in infants with congenital hypotonia . J Neurol Sci 1978;39:17-29.Crossref 20. Schloon H, Schottmann J, Lenard HG, et al: The development of skeletal muscles in premature infants . Eur J Pediatr 1979;131:49-60.Crossref 21. Farkas-Bargeton E, Dibler MF, Arsenio-Nunes ML, et al: Etude de la maturation histochimique quantitative et ultrastructurale du muscle foetal humain . J Neurol Sci 1974;31:245-259.Crossref 22. Kinoshita M, Satoyoshi E, Kumagai M: Familial type 1 fiber atrophy . J Neurol Sci 1975;25:11-17.Crossref 23. Fardeau M: Congenital myopathies , in Mastaglia FL, Walton JN (eds): Skeletal Muscle Pathology . Edinburgh, Churchill Livingstone, 1982, pp 161-203. 24. Curless RG, Nelson MB, Brimmer F: Histological patterns of muscle in infants with developmental brain abnormalities . Dev Med Child Neurol 1978;20:159-166.Crossref 25. Dubowitz V: Muscle Disorders in Childhood . London, WB Saunders Co, 1978. 26. Afifi AK, Zellweger H: Pathology of muscular hypotonia in the Prader-Willi syndrome light and electron microscopic study . J Neurol Sci 1969;9:49-61.Crossref 27. Matsuoko Y, Gubbay SS, Kakulas BA: A new myopathy with type II muscle fiber hypoplasia . Clin Exp Neurol 1974;11:155-159. 28. Dubrovsky A, Taratuto AL, Martino R: Distal spinal muscular atrophy and ophthalmoparesis: A case with selective type 2 fiber hypotrophy . Arch Neurol 1981;38:594-596.Crossref 29. Fenichel GM: Abnormalities of skeletal muscle maturation in brain damaged children: A histochemical study . Dev Med Child Neurol 1967;9:419-426.Crossref 30. Karpati G, Engel WK: Correlative histochemical study of skeletal muscle after suprasegmental denervation, peripheral nerve section and skeletal fixation . Neurology 1968;18:681-692.Crossref 31. Dubowitz V: Cross-innervated mammalian skeletal muscle: Histochemical, physiological and biochemical observation . J Physiol 1967; 193:481-496. 32. Karpati G, Engel WK: Transformation of the histochemical profile of skeletal muscle by 'foreign' innervation . Nature 1967:215:1509-1510.Crossref 33. Romanul FCA, Sreter FA, Salmons S, et al: The effects of a changed pattern of activity on histochemical characteristics of muscle fibers , in Milhorat AT (ed): Exploratory Concepts in Muscular Dystrophy . Amsterdam, Excerpta Medica, 1974, pp 344-348. 34. Munsat TL, McNeal D, Waters R: Effects of nerve stimulation on human muscle . Arch Neurol 1976;33:608-616.Crossref 35. Salmons S, Sereter FA: Significance of impulse activity in the transformation of skeletal muscle type . Nature 1976;263:30-34.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Jan 1, 1984

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