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Altered Muscle Saccharide Pattern in X-Linked Muscular Dystrophy

Altered Muscle Saccharide Pattern in X-Linked Muscular Dystrophy Abstract • Five lectins were used as fluorescence microscopic markers for sugar residues in skeletal muscle. Biopsy specimens were taken from patients with X-linked muscular dystrophy (Duchenne's and Becker's), patients with other neuromuscular diseases, and normal controls. In both the controls and the pathologic samples, concanavalin A gave a bright fluorescence of the myofiber surface, whereas soybean agglutinin and Dolichos biflorus agglutinin fluorescence was negative. Peanut agglutinin and wheat germ agglutinin were more avidly bound to the sarcolemma and/or endomysial connective tissue in the patients with X-linked muscular dystrophy than in the controls or the patients with other conditions. The altered saccharide pattern may reflect either a myofiber membrane change or a specific mesenchymal reaction in the dystrophic muscle. References 1. Dreyfus JC, Schapira G, Schapira F: Biochemical study of muscle in progressive muscular dystrophy . J Clin Invest 1954;33:794-797.Crossref 2. Ebashi S, Toyokura Y, Momoi H, et al: High creatine phosphokinase activity of sera of muscular dystrophy patients . J Biochem 1959;46:1203-1204. 3. Kunze D: Lipids: Composition and metabolism in human dystrophy , in Rowland LP (ed): Pathogenesis of Human Muscular Dystrophies . Amsterdam, Excerpta Medica, 1977, pp 404-414. 4. Kalofoutis A, Jullien G, Spanos V: Erythrocyte phospholipids in Duchenne muscular dystrophy . Clin Chim Acta 1977;74:85-87.Crossref 5. Ruitenbeck WIM: The fatty acid composition of various lipid fractions isolated from erythrocytes and blood plasma of patients with Duchenne and congenital myotonic dystrophy . Clin Chim Acta 1978;89:99-110.Crossref 6. Das PK, Graesskin D, Goedde HW: Apparent alterations of erythrocyte acetylcholinesterase and other membrane proteins in Duchenne muscular dystrophy: A further example of a generalized membrane defect associated with hereditary muscular dystrophy . Biochem Soc Trans 1976;4:723-724. 7. Brown HD, Chattpadhyay CH, Patel AB: Erythrocyte abnormality in human myopathy . Science 1967;157:1576-1577.Crossref 8. Araki S, Mawatari S: Oubain and erythrocyte-ghost adenosine triphophatase: Effects in human muscular dystrophies . Arch Neurol 1971;24:187-190.Crossref 9. Hodson A, Pleasure D: Erythrocyte cation-activated adenosine triphophatase in Duchenne muscular dystrophy . J Neurol Sci 1977;32:361-369.Crossref 10. Luthra MG, Stern LZ, Kim HD: (Ca++ + Mg++)-ATPase of red cells in Duchenne and myotonic dystrophy: Effect of soluble cytoplasmic activator . Neurology 1979;29:835-841.Crossref 11. Mawatari S, Tagaki R, Rowland LP: Adenyl cyclase in normal and pathologic human muscle . Arch Neurol 1974;30:96-102.Crossref 12. Butterfield DA, Chesnut DB, Appel SH, et al: Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophies and myotonia congenita . Nature 1976;263:159-161.Crossref 13. Fisher ER, Silvestri E, Vester IW, et al: Increased erythrocyte osmotic fragility in pseudohypertrophic muscular dystrophy . JAMA 1976;236-955. 14. Rowland LP: Biochemistry of muscle membranes in Duchenne muscular dystrophy . Muscle Nerve 1980;3:3-20.Crossref 15. Mokri B, Engel AG: Duchenne dystrophy: Electron microscopic findings pointing to a basic or early abnormality in the plasma membrane of the muscle fiber . Neurology 1975;25:1111-1120.Crossref 16. Schotland DL, Bonilla E, Wakayama Y: Application of the freeze fracture technique to the study of human neuromuscular disease . Muscle Nerve 1980;3:21-27.Crossref 17. Hughes RC: Membrane Glycoproteins: A Review of Structure and Function . Woburn, Mass, Butterworth Inc, 1976. 18. Hakomori S: Glycosphingolipids in cellular interaction, differentiation and oncogenesis . Ann Rev Biochem 1981;50:733-764.Crossref 19. Nicolson GL: The interactions of lectins with animal cell surfaces . Int Rev Cytol 1974;39:89-190. 20. Brown JE, Hunt RC: Lectins . Int Rev Cytol 1977;52:277-349. 21. Thoss K, Roth J: The use of fluorescein isothiocyanate labelled lectins for immunohistochemical demonstration of saccharides: III. Studies by use of Ricinus communis lectin and wheat germ agglutinin . Exp Pathol 1977;14:215-219. 22. Bonilla E, Schotland DL, Wakayama Y: Application of lectin cytochemistry to the study of human neuromuscular disease . Muscle Nerve 1980;3:28-35.Crossref 23. Pena SDJ, Gordon BB, Karpati G, et al: Lectin histochemistry of human skeletal muscle . J Histochem Cytochem 1981;29:542-546.Crossref 24. Henriksson KG: 'Semi-open' muscle biopsy technique: A simple outpatient procedure . Acta Neurol Scand 1979;59:317-323.Crossref 25. Dubowitz V, Brooke MH: Muscle Biopsy: A Modern Approach . Philadelphia, WB Saunders Co, 1973. 26. Lotan R, Skutelsky E, Danan D, et al: The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea) . J Biol Chem 1975;250:8518-8523. 27. Allen AK, Neuberger A, Sharon N: The purification, composition and specificity of wheat germ agglutinin . J Biochem 1973;131:155-162. 28. Monsigny M, Roche A-C, Sene C, et al: Sugar-lectin interactions: How does wheat germ agglutinin bind sialoglycoconjugates? Eur J Biochem 1980;104:147-153.Crossref 29. Yamada KM, Schlesinger DH, Kennedy DW, et al: Characterization of a major fibroblast cell surface glycoprotein . Biochemistry 1977; 16:5552-5559.Crossref 30. Chung AE, Jaffa R, Freeman IL, et al: Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line . Cell 1979;16:277-287.Crossref 31. Margolis RU, Margolis RK: Metabolism and function of glycoproteins and glycosaminoglycans in nervous tissue . Int J Biochem 1977;8:85-91.Crossref 32. Bourne GH, Golarz MN: Human muscular dystrophy as an aberration of the connective tissue . Nature 1959;183:1741-1743.Crossref 33. Bell CD, Conen PE: Histopathologial changes in Duchenne muscular dystrophy . J Neurol Sci 1968;7:529-544.Crossref 34. Thompson EJ, Yasin R, Van Beers G, et al: Myogenic defect in Duchenne muscular dystrophy . Nature 1977;268:241-247.Crossref 35. Duance VC, Stephens HR, Dunn M, et al: A role for collagen in the pathogenesis of muscular dystrophy? Nature 1980;284:470-472.Crossref 36. Dunn MJ, Sewry CA, Dubowitz V: Cytochemical studies of lectin binding by diseased human muscle . J Neurol Sci 1982;55:147-159.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Altered Muscle Saccharide Pattern in X-Linked Muscular Dystrophy

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1984.04050130045020
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Abstract

Abstract • Five lectins were used as fluorescence microscopic markers for sugar residues in skeletal muscle. Biopsy specimens were taken from patients with X-linked muscular dystrophy (Duchenne's and Becker's), patients with other neuromuscular diseases, and normal controls. In both the controls and the pathologic samples, concanavalin A gave a bright fluorescence of the myofiber surface, whereas soybean agglutinin and Dolichos biflorus agglutinin fluorescence was negative. Peanut agglutinin and wheat germ agglutinin were more avidly bound to the sarcolemma and/or endomysial connective tissue in the patients with X-linked muscular dystrophy than in the controls or the patients with other conditions. The altered saccharide pattern may reflect either a myofiber membrane change or a specific mesenchymal reaction in the dystrophic muscle. References 1. Dreyfus JC, Schapira G, Schapira F: Biochemical study of muscle in progressive muscular dystrophy . J Clin Invest 1954;33:794-797.Crossref 2. Ebashi S, Toyokura Y, Momoi H, et al: High creatine phosphokinase activity of sera of muscular dystrophy patients . J Biochem 1959;46:1203-1204. 3. Kunze D: Lipids: Composition and metabolism in human dystrophy , in Rowland LP (ed): Pathogenesis of Human Muscular Dystrophies . Amsterdam, Excerpta Medica, 1977, pp 404-414. 4. Kalofoutis A, Jullien G, Spanos V: Erythrocyte phospholipids in Duchenne muscular dystrophy . Clin Chim Acta 1977;74:85-87.Crossref 5. Ruitenbeck WIM: The fatty acid composition of various lipid fractions isolated from erythrocytes and blood plasma of patients with Duchenne and congenital myotonic dystrophy . Clin Chim Acta 1978;89:99-110.Crossref 6. Das PK, Graesskin D, Goedde HW: Apparent alterations of erythrocyte acetylcholinesterase and other membrane proteins in Duchenne muscular dystrophy: A further example of a generalized membrane defect associated with hereditary muscular dystrophy . Biochem Soc Trans 1976;4:723-724. 7. Brown HD, Chattpadhyay CH, Patel AB: Erythrocyte abnormality in human myopathy . Science 1967;157:1576-1577.Crossref 8. Araki S, Mawatari S: Oubain and erythrocyte-ghost adenosine triphophatase: Effects in human muscular dystrophies . Arch Neurol 1971;24:187-190.Crossref 9. Hodson A, Pleasure D: Erythrocyte cation-activated adenosine triphophatase in Duchenne muscular dystrophy . J Neurol Sci 1977;32:361-369.Crossref 10. Luthra MG, Stern LZ, Kim HD: (Ca++ + Mg++)-ATPase of red cells in Duchenne and myotonic dystrophy: Effect of soluble cytoplasmic activator . Neurology 1979;29:835-841.Crossref 11. Mawatari S, Tagaki R, Rowland LP: Adenyl cyclase in normal and pathologic human muscle . Arch Neurol 1974;30:96-102.Crossref 12. Butterfield DA, Chesnut DB, Appel SH, et al: Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophies and myotonia congenita . Nature 1976;263:159-161.Crossref 13. Fisher ER, Silvestri E, Vester IW, et al: Increased erythrocyte osmotic fragility in pseudohypertrophic muscular dystrophy . JAMA 1976;236-955. 14. Rowland LP: Biochemistry of muscle membranes in Duchenne muscular dystrophy . Muscle Nerve 1980;3:3-20.Crossref 15. Mokri B, Engel AG: Duchenne dystrophy: Electron microscopic findings pointing to a basic or early abnormality in the plasma membrane of the muscle fiber . Neurology 1975;25:1111-1120.Crossref 16. Schotland DL, Bonilla E, Wakayama Y: Application of the freeze fracture technique to the study of human neuromuscular disease . Muscle Nerve 1980;3:21-27.Crossref 17. Hughes RC: Membrane Glycoproteins: A Review of Structure and Function . Woburn, Mass, Butterworth Inc, 1976. 18. Hakomori S: Glycosphingolipids in cellular interaction, differentiation and oncogenesis . Ann Rev Biochem 1981;50:733-764.Crossref 19. Nicolson GL: The interactions of lectins with animal cell surfaces . Int Rev Cytol 1974;39:89-190. 20. Brown JE, Hunt RC: Lectins . Int Rev Cytol 1977;52:277-349. 21. Thoss K, Roth J: The use of fluorescein isothiocyanate labelled lectins for immunohistochemical demonstration of saccharides: III. Studies by use of Ricinus communis lectin and wheat germ agglutinin . Exp Pathol 1977;14:215-219. 22. Bonilla E, Schotland DL, Wakayama Y: Application of lectin cytochemistry to the study of human neuromuscular disease . Muscle Nerve 1980;3:28-35.Crossref 23. Pena SDJ, Gordon BB, Karpati G, et al: Lectin histochemistry of human skeletal muscle . J Histochem Cytochem 1981;29:542-546.Crossref 24. Henriksson KG: 'Semi-open' muscle biopsy technique: A simple outpatient procedure . Acta Neurol Scand 1979;59:317-323.Crossref 25. Dubowitz V, Brooke MH: Muscle Biopsy: A Modern Approach . Philadelphia, WB Saunders Co, 1973. 26. Lotan R, Skutelsky E, Danan D, et al: The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea) . J Biol Chem 1975;250:8518-8523. 27. Allen AK, Neuberger A, Sharon N: The purification, composition and specificity of wheat germ agglutinin . J Biochem 1973;131:155-162. 28. Monsigny M, Roche A-C, Sene C, et al: Sugar-lectin interactions: How does wheat germ agglutinin bind sialoglycoconjugates? Eur J Biochem 1980;104:147-153.Crossref 29. Yamada KM, Schlesinger DH, Kennedy DW, et al: Characterization of a major fibroblast cell surface glycoprotein . Biochemistry 1977; 16:5552-5559.Crossref 30. Chung AE, Jaffa R, Freeman IL, et al: Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line . Cell 1979;16:277-287.Crossref 31. Margolis RU, Margolis RK: Metabolism and function of glycoproteins and glycosaminoglycans in nervous tissue . Int J Biochem 1977;8:85-91.Crossref 32. Bourne GH, Golarz MN: Human muscular dystrophy as an aberration of the connective tissue . Nature 1959;183:1741-1743.Crossref 33. Bell CD, Conen PE: Histopathologial changes in Duchenne muscular dystrophy . J Neurol Sci 1968;7:529-544.Crossref 34. Thompson EJ, Yasin R, Van Beers G, et al: Myogenic defect in Duchenne muscular dystrophy . Nature 1977;268:241-247.Crossref 35. Duance VC, Stephens HR, Dunn M, et al: A role for collagen in the pathogenesis of muscular dystrophy? Nature 1980;284:470-472.Crossref 36. Dunn MJ, Sewry CA, Dubowitz V: Cytochemical studies of lectin binding by diseased human muscle . J Neurol Sci 1982;55:147-159.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Jan 1, 1984

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