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Is Calcitonin an Analgesic Hormone?

Is Calcitonin an Analgesic Hormone? Abstract To the Editor. —We have observed a 17-year-old boy with congenital absence of pain sensation and no demonstrable abnormalities in the peripheral and central pain-transmitting pathways.The patient, fully described earlier in this journal,1 had no neurologic defects except universal analgesia. He did not react to routine painful maneuvers, nor to high-intensity electrical stimulation of skin, nerve trunks, dorsal roots, tooth pulp, and corneal mucosa. Sharp-dull and hotcold discrimination were normal, as were proprioceptive sensation and deep reflexes. He had normal unmyelinated and myelinated fibers in skin nerve branches, and the corneal reflex latency was in the normal range. Stimulation of tooth pulp with electrical pulses evoked large cortical potentials in vertex recordings. On psychometric testing he was classified as dull normal, and his emotional reactions to psychological distress were adequate.This rare condition can be considered as a model of indifference to pain resulting from a central error References 1. Manfredi M, Bini G, Cruccu G, et al: Congenital absence of Pain . Arch Neurol 1981;38:507-511.Crossref 2. Becker KL, Snider RH, Moore CF, et al: Calcitonin in extrathyroidal tissues of man . Acta Endocrinol 1979;92:746-751. 3. Pavlinac DM, Lenhard LW, Parthemore JG, et al: Immunoreactive calcitonin in human cerebrospinal fluid . J Clin Endocrinol Metabol 1980; 50:717-720.Crossref 4. Deftos LJ, Burton D, Bone HG, et al: Immunoreactive calcitonin in the intermediate lobe of the pituitary gland . Life Sci 1979;23:743-748.Crossref 5. Pecile A, Ferri S, Braga PC, et al: Effect of intracerebroventricular calcitonin in the conscious rabbit . Experientia 1975;31:332-333.Crossref 6. Yamamoto M, Kumagai S, Tachikawa S, et al: Lack of effect of levallorphan on analgesia induced by intraventricular application of porcine calcitonin in mice . Eur J Pharmacol 1979; 55:211-213.Crossref 7. Braga P, Ferri S, Santagostino A, et al: Lack of opiate receptor involvement in centrally induced calcitonin analgesia . Life Sci 1978; 22:971-978.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Is Calcitonin an Analgesic Hormone?

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Is Calcitonin an Analgesic Hormone?

Abstract

Abstract To the Editor. —We have observed a 17-year-old boy with congenital absence of pain sensation and no demonstrable abnormalities in the peripheral and central pain-transmitting pathways.The patient, fully described earlier in this journal,1 had no neurologic defects except universal analgesia. He did not react to routine painful maneuvers, nor to high-intensity electrical stimulation of skin, nerve trunks, dorsal roots, tooth pulp, and corneal mucosa. Sharp-dull and hotcold...
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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1983.04050010084031
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —We have observed a 17-year-old boy with congenital absence of pain sensation and no demonstrable abnormalities in the peripheral and central pain-transmitting pathways.The patient, fully described earlier in this journal,1 had no neurologic defects except universal analgesia. He did not react to routine painful maneuvers, nor to high-intensity electrical stimulation of skin, nerve trunks, dorsal roots, tooth pulp, and corneal mucosa. Sharp-dull and hotcold discrimination were normal, as were proprioceptive sensation and deep reflexes. He had normal unmyelinated and myelinated fibers in skin nerve branches, and the corneal reflex latency was in the normal range. Stimulation of tooth pulp with electrical pulses evoked large cortical potentials in vertex recordings. On psychometric testing he was classified as dull normal, and his emotional reactions to psychological distress were adequate.This rare condition can be considered as a model of indifference to pain resulting from a central error References 1. Manfredi M, Bini G, Cruccu G, et al: Congenital absence of Pain . Arch Neurol 1981;38:507-511.Crossref 2. Becker KL, Snider RH, Moore CF, et al: Calcitonin in extrathyroidal tissues of man . Acta Endocrinol 1979;92:746-751. 3. Pavlinac DM, Lenhard LW, Parthemore JG, et al: Immunoreactive calcitonin in human cerebrospinal fluid . J Clin Endocrinol Metabol 1980; 50:717-720.Crossref 4. Deftos LJ, Burton D, Bone HG, et al: Immunoreactive calcitonin in the intermediate lobe of the pituitary gland . Life Sci 1979;23:743-748.Crossref 5. Pecile A, Ferri S, Braga PC, et al: Effect of intracerebroventricular calcitonin in the conscious rabbit . Experientia 1975;31:332-333.Crossref 6. Yamamoto M, Kumagai S, Tachikawa S, et al: Lack of effect of levallorphan on analgesia induced by intraventricular application of porcine calcitonin in mice . Eur J Pharmacol 1979; 55:211-213.Crossref 7. Braga P, Ferri S, Santagostino A, et al: Lack of opiate receptor involvement in centrally induced calcitonin analgesia . Life Sci 1978; 22:971-978.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Jan 1, 1983

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