Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Clomiphene as an Anticonvulsant Drug: A Case Report

Clomiphene as an Anticonvulsant Drug: A Case Report Abstract The effect of sex steroids on seizure disorders is controversial. Two controlled trials showed no effect1,2; however, there are other descriptions of patients whose attacks were aggravated by oral contraceptives.3,4 Some experimental evidence suggests that estrogens increase the electrical excitability of the brain.5 Clomiphene citrate, an antiestrogen drug, has been used to treat oligospermia and asthenospermia.6-8 In contrast to its use in women for infertility, where the drug is taken for only five days each month, clomiphene is used in men for at least 25 days per month. Whether the drug is safe to use in either men or women with a seizure disorder is not known. If the evidence that estrogen adversely affects seizure disorders is correct, then this antiestrogen drug might have an ameliorative effect. However, there is some evidence that clomiphene may act as an estrogen in a man.9 Thus, its References 1. Toivakka E: Oral contraception in epileptics . Arzneimittelforsch 1967;17:1085. 2. Espir M, Walker ME, Lawson JP: Epilepsy and oral contraception . Br Med J 1969;1:294-295.Crossref 3. Cole M: Etiology of grand mal seizures in patient on oral contraceptive . JAMA 1969;208:158-159.Crossref 4. Oral contraceptives and epilepsy, Notes and Comments . Br Med J 1969;4:672.Crossref 5. Sanchez-Longo LP, Saldana LEG: Hormones and their influence in epilepsy . Acta Neurol Latinoam 1966;12:29-47. 6. Check JH, Rakoff AE: Improved fertility in oligospermic males treated with clomiphene citrate . Fertil Steril 1977;28:746-748. 7. Check JH: Improved semen quality in subfertile males with varicoele-associated oligospermia following treatment with clomiphene citrate . Fertil Steril 1981;33:423-426. 8. Paulson DE, Wacksman J: Clomiphene citrate in the management of male infertility . J Urol 1976;115:73-76. 9. Check JH, Murdock MG, Caro JF: Case report: Cystic gynecomastia in a male treated with clomiphene citrate . Fertil Steril 1978;30:713-715. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Clomiphene as an Anticonvulsant Drug: A Case Report

Clomiphene as an Anticonvulsant Drug: A Case Report

Abstract

Abstract The effect of sex steroids on seizure disorders is controversial. Two controlled trials showed no effect1,2; however, there are other descriptions of patients whose attacks were aggravated by oral contraceptives.3,4 Some experimental evidence suggests that estrogens increase the electrical excitability of the brain.5 Clomiphene citrate, an antiestrogen drug, has been used to treat oligospermia and asthenospermia.6-8 In contrast to its use in women for infertility, where the drug is...
Loading next page...
 
/lp/american-medical-association/clomiphene-as-an-anticonvulsant-drug-a-case-report-OHnJf46gw2

References (10)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1982.00510240046014
Publisher site
See Article on Publisher Site

Abstract

Abstract The effect of sex steroids on seizure disorders is controversial. Two controlled trials showed no effect1,2; however, there are other descriptions of patients whose attacks were aggravated by oral contraceptives.3,4 Some experimental evidence suggests that estrogens increase the electrical excitability of the brain.5 Clomiphene citrate, an antiestrogen drug, has been used to treat oligospermia and asthenospermia.6-8 In contrast to its use in women for infertility, where the drug is taken for only five days each month, clomiphene is used in men for at least 25 days per month. Whether the drug is safe to use in either men or women with a seizure disorder is not known. If the evidence that estrogen adversely affects seizure disorders is correct, then this antiestrogen drug might have an ameliorative effect. However, there is some evidence that clomiphene may act as an estrogen in a man.9 Thus, its References 1. Toivakka E: Oral contraception in epileptics . Arzneimittelforsch 1967;17:1085. 2. Espir M, Walker ME, Lawson JP: Epilepsy and oral contraception . Br Med J 1969;1:294-295.Crossref 3. Cole M: Etiology of grand mal seizures in patient on oral contraceptive . JAMA 1969;208:158-159.Crossref 4. Oral contraceptives and epilepsy, Notes and Comments . Br Med J 1969;4:672.Crossref 5. Sanchez-Longo LP, Saldana LEG: Hormones and their influence in epilepsy . Acta Neurol Latinoam 1966;12:29-47. 6. Check JH, Rakoff AE: Improved fertility in oligospermic males treated with clomiphene citrate . Fertil Steril 1977;28:746-748. 7. Check JH: Improved semen quality in subfertile males with varicoele-associated oligospermia following treatment with clomiphene citrate . Fertil Steril 1981;33:423-426. 8. Paulson DE, Wacksman J: Clomiphene citrate in the management of male infertility . J Urol 1976;115:73-76. 9. Check JH, Murdock MG, Caro JF: Case report: Cystic gynecomastia in a male treated with clomiphene citrate . Fertil Steril 1978;30:713-715.

Journal

Archives of NeurologyAmerican Medical Association

Published: Dec 1, 1982

There are no references for this article.