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Regular Involvement of Clarke's Nucleus in Sporadic Amyotrophic Lateral Sclerosis

Regular Involvement of Clarke's Nucleus in Sporadic Amyotrophic Lateral Sclerosis Abstract • Morphometric study of Clarke's nucleus in 12 cases of sporadic amyotrophic lateral sclerosis and 12 normal control subjects showed an average 36% reduction in the neuronal population in the disease group, with involvement in each case. Histopathologic findings of cell degeneration were definite but less noticeable than in the ventral horns. The process seems likely to be similar to that affecting motor neurons but is less advanced at the time of death. References 1. Holmes G: The pathology of amyotrophic lateral sclerosis . Rev Neurol Psychiatry 1909;7:693-725. 2. Brownnell B, Oppenheimer DR, Hughes JT: The central nervous system in motor neuron disease . J Neurol Neurosurg Psychiatry 1970;33:338.Crossref 3. Friedman AP, Freedman DA: Amyotrophic lateral sclerosis . J Nerv Ment Dis 1950;111:1.Crossref 4. Greenfield JG: System degeneration of the cerebellum, brain stem and spinal cord , in Norman RM (ed): Greenfield's Neuropathology . London, Edward Arnold & Co Ltd, 1963, pp 595-599. 5. Hirano A, Malamud N, Kurland LT, et al: A review of the pathologic findings in amyotrophic lateral sclerosis , in Norris FH Jr, Kurland LT (eds): Motor Neuron Diseases . New York, Grune & Stratton Inc, 1969, pp 51-60. 6. Lawyer T Jr, Netzky MG: Amyotrophic lateral sclerosis: A clinicoanatomical study of 53 cases . Arch Neurol Psychiatry 1953;69:171.Crossref 7. Wohlfart G: Degenerative and regenerative axonal changes in the ventral horns, brainstem and cerebral cortex in amyotrophic lateral sclerosis . Acta Univ Lund 1959;56:1. 8. Carpenter S: Proximal axonal enlargement in motor neuron disease . Neurology 1968;18:841-851.Crossref 9. Hirano A, Kurland LT, Sayre GP: Familial amyotrophic lateral sclerosis: A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells . Arch Neurol 1967;16:232-243.Crossref 10. Carpenter S, Karpati G, Rothman S, et al: Pathological involvement of primary sensory neurons in Werdnig-Hoffmann disease . Acta Neuropathol 1978;42:91-97.Crossref 11. Cavanagh JB: The 'dying back' process . Arch Pathol Lab Med 1979;103:659-664. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Regular Involvement of Clarke's Nucleus in Sporadic Amyotrophic Lateral Sclerosis

Averback, Paul; Crocker, Paul
Archives of Neurology , Volume 39 (3) – Mar 1, 1982
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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1982.00510150025006
Publisher site
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Abstract

Abstract • Morphometric study of Clarke's nucleus in 12 cases of sporadic amyotrophic lateral sclerosis and 12 normal control subjects showed an average 36% reduction in the neuronal population in the disease group, with involvement in each case. Histopathologic findings of cell degeneration were definite but less noticeable than in the ventral horns. The process seems likely to be similar to that affecting motor neurons but is less advanced at the time of death. References 1. Holmes G: The pathology of amyotrophic lateral sclerosis . Rev Neurol Psychiatry 1909;7:693-725. 2. Brownnell B, Oppenheimer DR, Hughes JT: The central nervous system in motor neuron disease . J Neurol Neurosurg Psychiatry 1970;33:338.Crossref 3. Friedman AP, Freedman DA: Amyotrophic lateral sclerosis . J Nerv Ment Dis 1950;111:1.Crossref 4. Greenfield JG: System degeneration of the cerebellum, brain stem and spinal cord , in Norman RM (ed): Greenfield's Neuropathology . London, Edward Arnold & Co Ltd, 1963, pp 595-599. 5. Hirano A, Malamud N, Kurland LT, et al: A review of the pathologic findings in amyotrophic lateral sclerosis , in Norris FH Jr, Kurland LT (eds): Motor Neuron Diseases . New York, Grune & Stratton Inc, 1969, pp 51-60. 6. Lawyer T Jr, Netzky MG: Amyotrophic lateral sclerosis: A clinicoanatomical study of 53 cases . Arch Neurol Psychiatry 1953;69:171.Crossref 7. Wohlfart G: Degenerative and regenerative axonal changes in the ventral horns, brainstem and cerebral cortex in amyotrophic lateral sclerosis . Acta Univ Lund 1959;56:1. 8. Carpenter S: Proximal axonal enlargement in motor neuron disease . Neurology 1968;18:841-851.Crossref 9. Hirano A, Kurland LT, Sayre GP: Familial amyotrophic lateral sclerosis: A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells . Arch Neurol 1967;16:232-243.Crossref 10. Carpenter S, Karpati G, Rothman S, et al: Pathological involvement of primary sensory neurons in Werdnig-Hoffmann disease . Acta Neuropathol 1978;42:91-97.Crossref 11. Cavanagh JB: The 'dying back' process . Arch Pathol Lab Med 1979;103:659-664.

Journal

Archives of Neurology – American Medical Association

Published: Mar 1, 1982

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