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Use of Valproic Acid in Treatment of Infantile Spasms

Use of Valproic Acid in Treatment of Infantile Spasms Abstract • Nineteen babies with infantile spasms were treated with valproic acid over a two-year period. Eleven of the patients were also treated with purified corticotropin, but in no cases were the two drugs used simultaneously. Approximately 40% of the patients had good control of their infantile spasms with valproic acid. Side effects from valproic acid in these babies were not frequent and were, for the most part, minor. Though the percentage of infants with infantile spasms responding to valproic acid may be less than the percentage responding to corticotropin, the incidence and severity of side effects are less with valproic acid. References 1. Swaiman KF, Wright FS: The Practice of Pediatric Neurology . St Louis, CV Mosby Co, 1975, vol 2, p 861. 2. Simon D, Penry JK: Sodium di-N-propylacetate (DPA) in the treatment of epilepsy: A review . Epilepsia 1975;16:549-573.Crossref 3. Pinder RM, Brogden RN, Speight TM, et al: Sodium valproate: A review of its pharmacological properties and therapeutic efficacy in epilepsy . Drugs 1977;13:81-123.Crossref 4. Bruni J, Wilder BJ: Valproic acid: Review of the new antiepileptic drug . Arch Neurol 1979;36:393-398.Crossref 5. Barnes SE, Bower BD: Sodium valproate in the treatment of intractable childhood epilepsy . Dev Med Child Neurol 1975;17:175-181.Crossref 6. Rohmann E, Arndi R: The efficacy of ergenyl (dipropyl acetate) in clonic- jackknife- and salaam spasms . Kinderaertzl Prax 1976;44:109-113. 7. Olive D, Tridon P, Weber M, et al: Action du dipropylacétate de sodium sur certaines variétés d'encéphalopathies épileptogénes du nourrisson . Schweiz Med Wochenschr 1969;99:87-92. 8. Trompetter-Van Woerden ML, van der Zwan A: Ervaringen met valproïnezuur (Depakine) bij de behandeling van epilepsie . Ned Tijdschr Geneeskd 1977;121:578-590. 9. Yokoyama S, Kodama S, Ogino H, et al: Study on the treatment of infantile spasms . Brain Dev 1976;8:447-453. 10. Brachet-Liermain A, Demarquez JL: Pharmokinetics of dipropyl acetate in infants and young children . Pharm Weekbl 1977;112:293-297. 11. Jeavons PM, Bower BD, Dimitrakqudi M: Long term prognosis of 150 cases of 'West syndrome.' Epilepsia 1973;14:153-164.Crossref 12. Singer WD, Rabe EF, Haller JS: The effect of ACTH therapy upon infantile spasms . J Pediatr 1980;96:485-489.Crossref 13. Pollack MA, Zion TE, Kellaway P: Long-term prognosis of patients with infantile spasms following ACTH therapy . Epilepsia 1979;20:255-260.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Use of Valproic Acid in Treatment of Infantile Spasms

Bachman, David S.
Archives of Neurology , Volume 39 (1) – Jan 1, 1982
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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1982.00510130051013
Publisher site
See Article on Publisher Site

Abstract

Abstract • Nineteen babies with infantile spasms were treated with valproic acid over a two-year period. Eleven of the patients were also treated with purified corticotropin, but in no cases were the two drugs used simultaneously. Approximately 40% of the patients had good control of their infantile spasms with valproic acid. Side effects from valproic acid in these babies were not frequent and were, for the most part, minor. Though the percentage of infants with infantile spasms responding to valproic acid may be less than the percentage responding to corticotropin, the incidence and severity of side effects are less with valproic acid. References 1. Swaiman KF, Wright FS: The Practice of Pediatric Neurology . St Louis, CV Mosby Co, 1975, vol 2, p 861. 2. Simon D, Penry JK: Sodium di-N-propylacetate (DPA) in the treatment of epilepsy: A review . Epilepsia 1975;16:549-573.Crossref 3. Pinder RM, Brogden RN, Speight TM, et al: Sodium valproate: A review of its pharmacological properties and therapeutic efficacy in epilepsy . Drugs 1977;13:81-123.Crossref 4. Bruni J, Wilder BJ: Valproic acid: Review of the new antiepileptic drug . Arch Neurol 1979;36:393-398.Crossref 5. Barnes SE, Bower BD: Sodium valproate in the treatment of intractable childhood epilepsy . Dev Med Child Neurol 1975;17:175-181.Crossref 6. Rohmann E, Arndi R: The efficacy of ergenyl (dipropyl acetate) in clonic- jackknife- and salaam spasms . Kinderaertzl Prax 1976;44:109-113. 7. Olive D, Tridon P, Weber M, et al: Action du dipropylacétate de sodium sur certaines variétés d'encéphalopathies épileptogénes du nourrisson . Schweiz Med Wochenschr 1969;99:87-92. 8. Trompetter-Van Woerden ML, van der Zwan A: Ervaringen met valproïnezuur (Depakine) bij de behandeling van epilepsie . Ned Tijdschr Geneeskd 1977;121:578-590. 9. Yokoyama S, Kodama S, Ogino H, et al: Study on the treatment of infantile spasms . Brain Dev 1976;8:447-453. 10. Brachet-Liermain A, Demarquez JL: Pharmokinetics of dipropyl acetate in infants and young children . Pharm Weekbl 1977;112:293-297. 11. Jeavons PM, Bower BD, Dimitrakqudi M: Long term prognosis of 150 cases of 'West syndrome.' Epilepsia 1973;14:153-164.Crossref 12. Singer WD, Rabe EF, Haller JS: The effect of ACTH therapy upon infantile spasms . J Pediatr 1980;96:485-489.Crossref 13. Pollack MA, Zion TE, Kellaway P: Long-term prognosis of patients with infantile spasms following ACTH therapy . Epilepsia 1979;20:255-260.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Jan 1, 1982

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