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Comprehensive Viral Immunology of Multiple Sclerosis: I. Clinical, Epidemiological, and CSF Studies

Comprehensive Viral Immunology of Multiple Sclerosis: I. Clinical, Epidemiological, and CSF Studies Abstract • Epidemiological, clinical, and CSF data were collected on 87 patients with clinically definite multiple sclerosis (MS) and 50 with probable MS. As part of a study of immunologic reactivity to viral antigens, a control group separated into 26 patients with probable inflammatory neural disease and 140 with noninflammatory neural disease was similarly studied. Among the groups with MS, females predominated and both Oriental and Spanish surnamed patients were underrepresented. The spinal cord, optic nerves, and brainstem were the most common sites of initial disease and more than 20% of the patients had only cord symptoms after several years of disease activity. Of several CSF assays used, determination of oligoclonal IgG bands by agarose electrophoresis was most useful diagnostically. References 1. Johnson RT: The possible viral etiology of multiple sclerosis , in Friedlander, WJ (ed): Advances in Neurology , New York, Raven Press, 1975, vol 13, pp 1-46. 2. Norrby E: Viral antibodies in multiple sclerosis . Prog Med Virol 24:1-39, 1978. 3. Norrby E, Link H, Olsson JE, et al: Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis . Infect Immunol 19:688-694, 1974. 4. Cremer NE, Johnson KP, Fein G, et al: Comprehensive viral immunology of multiple sclerosis: II. Analysis of serum and CSF antibodies by standard serologic methods . Arch Neurol , to be published. 5. Forghani B, Cremer NE, Johnson KP, et al: Comprehensive viral immunology of multiple sclerosis: III. Analysis of CSF antibodies by radioimmunoassay . Arch Neurol , to be published. 6. Johnson KP, Arrigo SC, Nelson BJ, et al: Agarose electrophoresis of cerebrospinal fluid . Neurology 27:273-277, 1977.Crossref 7. Johnson KP, Nelson BJ: Multiple sclerosis: Diagnostic usefulness of cerebrospinal fluid . Ann Neurol 2:425-431, 1977.Crossref 8. Forghani B, Cremer NE, Johnson KP, et al: Viral antibodies in cerebrospinal fluid of multiple sclerosis and control patients: Comparison between radioimmunassay and conventional techniques . Clin Microbiol 7:63-69, 1978. 9. McDonald WI, Halliday AM: Diagnosis and classification of multiple sclerosis . Br Med Bull 33:4-8, 1977. 10. Kuroiwa Y, Iwashita H: The current status of multiple sclerosis studies in Japan . Asian Med J 20:335-351, 1977. 11. Immuno-plate III, Radial immunodiffusion test. Human IgG and albumin test. Costa Mesa, Calif, Hyland Laboratories, No. 92626, 1974. 12. Tourtellotte WW: What is multiple sclerosis: Laboratory criteria for diagnosis , in Davison AN, Humphrey JH, Liversedge AL, et al(eds): Multiple Sclerosis Research . Amsterdam, Elsevier Scientific Publishing Co, 1975. 13. Enstrom JE, Operskalski EA: Multiple sclerosis among Spanish-surnamed Californians . Neurology 38:434-438, 1978.Crossref 14. McAlpine D: The problem of diagnosis , in McAlpine D (ed): Multiple Sclerosis: A Reappraisal . London, E & S Livingstone Ltd, 1968, pp 142-178. 15. Link H, Norrby E, Olsson JE: Immunoglobulin abnormalities and measles antibody response in chronic myelopathy . Arch Neurol 33:26-32, 1976.Crossref 16. Brain R, Wilkinson M: The association of cervical spondylosis and disseminated sclerosis . Brain 80:456-478, 1957.Crossref 17. Thompson EJ: Laboratory diagnosis of multiple sclerosis: Immunological and biochemical aspects . Br Med Bull 33:28-33, 1977. 18. Johnson KP, Cremer NE, Forghani B: Viral antibody and protein studies of cerebrospinal fluid: Diagnostic usefulness in multiple sclerosis , in Karcher D, Lowenthal A, Strosberg AD (eds): Humoral Immunity in Neurological Diseases . New York, Plenum Publishing Corp, 1979, pp 233-237. 19. Link H: Demonstration of oligoclonal immunoglobulin G in Guillain-Barre syndrome . Acta Neurol Scand 52:111-120, 1975.Crossref 20. Traviesa DC, Prystowsky SD, Nelson BJ, et al: Cerebrospinal fluid (CSF) findings in asymptomatic patients with reactive serum fluorescent treponemal antibody absorption (FTA-ABS) tests . Ann Neurol 4:524-530, 1978.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Comprehensive Viral Immunology of Multiple Sclerosis: I. Clinical, Epidemiological, and CSF Studies

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1980.00500580033003
Publisher site
See Article on Publisher Site

Abstract

Abstract • Epidemiological, clinical, and CSF data were collected on 87 patients with clinically definite multiple sclerosis (MS) and 50 with probable MS. As part of a study of immunologic reactivity to viral antigens, a control group separated into 26 patients with probable inflammatory neural disease and 140 with noninflammatory neural disease was similarly studied. Among the groups with MS, females predominated and both Oriental and Spanish surnamed patients were underrepresented. The spinal cord, optic nerves, and brainstem were the most common sites of initial disease and more than 20% of the patients had only cord symptoms after several years of disease activity. Of several CSF assays used, determination of oligoclonal IgG bands by agarose electrophoresis was most useful diagnostically. References 1. Johnson RT: The possible viral etiology of multiple sclerosis , in Friedlander, WJ (ed): Advances in Neurology , New York, Raven Press, 1975, vol 13, pp 1-46. 2. Norrby E: Viral antibodies in multiple sclerosis . Prog Med Virol 24:1-39, 1978. 3. Norrby E, Link H, Olsson JE, et al: Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis . Infect Immunol 19:688-694, 1974. 4. Cremer NE, Johnson KP, Fein G, et al: Comprehensive viral immunology of multiple sclerosis: II. Analysis of serum and CSF antibodies by standard serologic methods . Arch Neurol , to be published. 5. Forghani B, Cremer NE, Johnson KP, et al: Comprehensive viral immunology of multiple sclerosis: III. Analysis of CSF antibodies by radioimmunoassay . Arch Neurol , to be published. 6. Johnson KP, Arrigo SC, Nelson BJ, et al: Agarose electrophoresis of cerebrospinal fluid . Neurology 27:273-277, 1977.Crossref 7. Johnson KP, Nelson BJ: Multiple sclerosis: Diagnostic usefulness of cerebrospinal fluid . Ann Neurol 2:425-431, 1977.Crossref 8. Forghani B, Cremer NE, Johnson KP, et al: Viral antibodies in cerebrospinal fluid of multiple sclerosis and control patients: Comparison between radioimmunassay and conventional techniques . Clin Microbiol 7:63-69, 1978. 9. McDonald WI, Halliday AM: Diagnosis and classification of multiple sclerosis . Br Med Bull 33:4-8, 1977. 10. Kuroiwa Y, Iwashita H: The current status of multiple sclerosis studies in Japan . Asian Med J 20:335-351, 1977. 11. Immuno-plate III, Radial immunodiffusion test. Human IgG and albumin test. Costa Mesa, Calif, Hyland Laboratories, No. 92626, 1974. 12. Tourtellotte WW: What is multiple sclerosis: Laboratory criteria for diagnosis , in Davison AN, Humphrey JH, Liversedge AL, et al(eds): Multiple Sclerosis Research . Amsterdam, Elsevier Scientific Publishing Co, 1975. 13. Enstrom JE, Operskalski EA: Multiple sclerosis among Spanish-surnamed Californians . Neurology 38:434-438, 1978.Crossref 14. McAlpine D: The problem of diagnosis , in McAlpine D (ed): Multiple Sclerosis: A Reappraisal . London, E & S Livingstone Ltd, 1968, pp 142-178. 15. Link H, Norrby E, Olsson JE: Immunoglobulin abnormalities and measles antibody response in chronic myelopathy . Arch Neurol 33:26-32, 1976.Crossref 16. Brain R, Wilkinson M: The association of cervical spondylosis and disseminated sclerosis . Brain 80:456-478, 1957.Crossref 17. Thompson EJ: Laboratory diagnosis of multiple sclerosis: Immunological and biochemical aspects . Br Med Bull 33:28-33, 1977. 18. Johnson KP, Cremer NE, Forghani B: Viral antibody and protein studies of cerebrospinal fluid: Diagnostic usefulness in multiple sclerosis , in Karcher D, Lowenthal A, Strosberg AD (eds): Humoral Immunity in Neurological Diseases . New York, Plenum Publishing Corp, 1979, pp 233-237. 19. Link H: Demonstration of oligoclonal immunoglobulin G in Guillain-Barre syndrome . Acta Neurol Scand 52:111-120, 1975.Crossref 20. Traviesa DC, Prystowsky SD, Nelson BJ, et al: Cerebrospinal fluid (CSF) findings in asymptomatic patients with reactive serum fluorescent treponemal antibody absorption (FTA-ABS) tests . Ann Neurol 4:524-530, 1978.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Sep 1, 1980

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