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Hypokalemic Periodic Paralysis

Hypokalemic Periodic Paralysis Abstract To the Editor.— Hypokalemic periodic paralysis has been treated in many ways, such as by the use of potassium supplements and spironolactone to increase the patient's level of potassium1 and most recently by the use of acetazolamide.2 This last method is thought not to alter potassium metabolism3 but rather to work through the creation of metabolic acidosis.4 However, one patient had documented hypokalemic periodic paralysis that was unresponsive to all of these modes of therapy. Report of a Case.— The patient, a 14-year-old boy, had been having frequent attacks of paralysis of varying degrees, which were sufficient to keep him home from school four to five times each month. The disease had been documented by a low level of potassium in the blood during the attacks, with a normal level of potassium at other times, in addition to the characteristic picture of exercise-induced and early morning References 1. Pearson JM, Kalyanarman K: The periodic paralysis , in Stanbury JB, Wyngaarden JB, Fredrickson DS, (eds): The Metabolic Bases of Inherited Disease . New York, McGraw Hill Book Co Inc, 1972. 2. Resnick JS, Engel WK, Griggs RC, et al: Acetazolamide prophylaxis in hypokalemic periodic paralysis . New Engl J Med 278:582-586, 1968.Crossref 3. Viskoper FJ, Licht A, Fidel J, et al: Acetazolamide treatment in hypokalemic periodic paralysis: A metabolic and electromyographic study . Am J Med Sci 266:119-123, 1973.Crossref 4. Vroom FW, Jarrell MA, Maren TH: Acetazolamide treatment of hypokalemic periodic paralysis, probable mechanism of action . Arch Neurol 32:385-392, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Hypokalemic Periodic Paralysis

Roeltgen, D.
Archives of Neurology , Volume 36 (7) – Jul 1, 1979
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Hypokalemic Periodic Paralysis

Abstract

Abstract To the Editor.— Hypokalemic periodic paralysis has been treated in many ways, such as by the use of potassium supplements and spironolactone to increase the patient's level of potassium1 and most recently by the use of acetazolamide.2 This last method is thought not to alter potassium metabolism3 but rather to work through the creation of metabolic acidosis.4 However, one patient had documented hypokalemic periodic paralysis that was unresponsive to all of these modes of...
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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1979.00500430083021
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Hypokalemic periodic paralysis has been treated in many ways, such as by the use of potassium supplements and spironolactone to increase the patient's level of potassium1 and most recently by the use of acetazolamide.2 This last method is thought not to alter potassium metabolism3 but rather to work through the creation of metabolic acidosis.4 However, one patient had documented hypokalemic periodic paralysis that was unresponsive to all of these modes of therapy. Report of a Case.— The patient, a 14-year-old boy, had been having frequent attacks of paralysis of varying degrees, which were sufficient to keep him home from school four to five times each month. The disease had been documented by a low level of potassium in the blood during the attacks, with a normal level of potassium at other times, in addition to the characteristic picture of exercise-induced and early morning References 1. Pearson JM, Kalyanarman K: The periodic paralysis , in Stanbury JB, Wyngaarden JB, Fredrickson DS, (eds): The Metabolic Bases of Inherited Disease . New York, McGraw Hill Book Co Inc, 1972. 2. Resnick JS, Engel WK, Griggs RC, et al: Acetazolamide prophylaxis in hypokalemic periodic paralysis . New Engl J Med 278:582-586, 1968.Crossref 3. Viskoper FJ, Licht A, Fidel J, et al: Acetazolamide treatment in hypokalemic periodic paralysis: A metabolic and electromyographic study . Am J Med Sci 266:119-123, 1973.Crossref 4. Vroom FW, Jarrell MA, Maren TH: Acetazolamide treatment of hypokalemic periodic paralysis, probable mechanism of action . Arch Neurol 32:385-392, 1975.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Jul 1, 1979

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