Reversible Hepatic Dysfunction Owing to Guanidine Treatment
Abstract
Abstract To the Editor.— Guanidine hydrochloride is of value in the treatment of the Lambert-Eaton syndrome1 and botulism.2 More recently, it was tried in the treatment of motor neuron disease.3Untoward side effects are frequent and include the following: cholinergic reactions of the gastrointestional (GI) system, paresthesias, skin changes, petechiae, and, with high doses, nervousness, tremors, and ataxia1,3,4 More serious are the occasional occurrences of bone marrow depression and...