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Neuralgia in Recurrent Herpes Simplex

Neuralgia in Recurrent Herpes Simplex Abstract Five patients with recurrent herpes simplex of the skin had unusual neuralgic pains preceding the eruptions by 24 hours or more. Although prodromal neuralgia is an uncommon feature of recurrent herpes, about 15 similar cases have been reported previously. The pain is often diffuse and aching in character and, in contrast with herpes zoster, leaves no sensory or motor deficit. Stereotyped cycles of pain and herpes simplex may occur repeatedly for as long as 20 years. The fact that pain precedes the eruption supports the theory that a persistent latent infection of sensory ganglia is activated during recurrences of herpes simplex. References 1. Nicolau S, Poincloux P: Etude clinique et expérimentale d'un cas d'herpès récidivant du doigt . Ann Inst Pasteur 38:977-1001, 1924. 2. Slavin HB, Ferguson JJ Jr: Zoster-like eruptions caused by the virus of herpes simplex . Am J Med 8:456-467, 1950.Crossref 3. Behrman S, Knight G: Herpes simplex associated with trigeminal neuralgia . Neurology 4:525-530, 1954.Crossref 4. Constantine VS, Francis RD, Montes LF: Association of recurrent herpes simplex with neuralgia . JAMA 205:131-133, 1968.Crossref 5. Selmanowitz VJ: Prodromata of cutaneous herpes simplex . Cutis 4:1071-1075, 1968. 6. Selmanowitz VJ: Neurocutaneous herpes simplex . Int J Dermatol 10:227-232, 1971.Crossref 7. Wilson SAK: Neurology , ed 2. Bruce AN, (ed), London, Butterworth & Co, 1954, vol 2, pp 774-788. 8. Burgoon CF, Burgoon JS, Baldridge GD: The natural history of herpes zoster . JAMA 164:265-269, 1957.Crossref 9. Taterka JH, O'Sullivan ME: The motor complications of herpes zoster . JAMA 122:737-739, 1943.Crossref 10. Kendall D: Motor complications of herpes zoster . Br Med J 2:616-618, 1957.Crossref 11. Merritt HH, Fremont-Smith F: The Cerebrospinal Fluid . Philadelphia, WB Saunders Co, 1938, p 136. 12. Denny-Brown D, Adams RD, Fitzgerald PJ: Pathologic features of herpes zoster: A note on "geniculate herpes." Arch Neurol Psychiatry 51:216-231, 1944.Crossref 13. Shearer ML, Finch SM: Periodic organic psychosis associated with recurrent herpes simplex . N Engl J Med 271:494-497, 1964.Crossref 14. Carton CA: Effect of previous sensory loss on the appearance of herpes simplex following trigeminal sensory root section . J Neurosurg 10:463-468, 1953.Crossref 15. Baringer JR, Swoveland P: Recovery of herpes simplex virus from human trigeminal ganglions . N Engl J Med 288:648-650, 1973.Crossref 16. Bastian FO, et al: Herpesvirus hominis: Isolation from human trigeminal ganglion . Science 178:306-307, 1972.Crossref 17. Stevens JG, Cook ML: Latent herpes virus in spinal ganglia of mice . Science 173:843-845, 1971.Crossref 18. Kern AB, Schiff BL: Smallpox vaccinations in management of recurrent herpes simplex: Controlled evaluation . J Invest Dermatol 33:99-102, 1959.Crossref 19. Felber TD, et al: Photodynamic inactivation of herpes simplex . JAMA 223:289-292, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Neuralgia in Recurrent Herpes Simplex

Layzer, Robert B.; Conant, Marcus A.
Archives of Neurology , Volume 31 (4) – Oct 1, 1974
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References (24)

Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1974.00490400047004
Publisher site
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Abstract

Abstract Five patients with recurrent herpes simplex of the skin had unusual neuralgic pains preceding the eruptions by 24 hours or more. Although prodromal neuralgia is an uncommon feature of recurrent herpes, about 15 similar cases have been reported previously. The pain is often diffuse and aching in character and, in contrast with herpes zoster, leaves no sensory or motor deficit. Stereotyped cycles of pain and herpes simplex may occur repeatedly for as long as 20 years. The fact that pain precedes the eruption supports the theory that a persistent latent infection of sensory ganglia is activated during recurrences of herpes simplex. References 1. Nicolau S, Poincloux P: Etude clinique et expérimentale d'un cas d'herpès récidivant du doigt . Ann Inst Pasteur 38:977-1001, 1924. 2. Slavin HB, Ferguson JJ Jr: Zoster-like eruptions caused by the virus of herpes simplex . Am J Med 8:456-467, 1950.Crossref 3. Behrman S, Knight G: Herpes simplex associated with trigeminal neuralgia . Neurology 4:525-530, 1954.Crossref 4. Constantine VS, Francis RD, Montes LF: Association of recurrent herpes simplex with neuralgia . JAMA 205:131-133, 1968.Crossref 5. Selmanowitz VJ: Prodromata of cutaneous herpes simplex . Cutis 4:1071-1075, 1968. 6. Selmanowitz VJ: Neurocutaneous herpes simplex . Int J Dermatol 10:227-232, 1971.Crossref 7. Wilson SAK: Neurology , ed 2. Bruce AN, (ed), London, Butterworth & Co, 1954, vol 2, pp 774-788. 8. Burgoon CF, Burgoon JS, Baldridge GD: The natural history of herpes zoster . JAMA 164:265-269, 1957.Crossref 9. Taterka JH, O'Sullivan ME: The motor complications of herpes zoster . JAMA 122:737-739, 1943.Crossref 10. Kendall D: Motor complications of herpes zoster . Br Med J 2:616-618, 1957.Crossref 11. Merritt HH, Fremont-Smith F: The Cerebrospinal Fluid . Philadelphia, WB Saunders Co, 1938, p 136. 12. Denny-Brown D, Adams RD, Fitzgerald PJ: Pathologic features of herpes zoster: A note on "geniculate herpes." Arch Neurol Psychiatry 51:216-231, 1944.Crossref 13. Shearer ML, Finch SM: Periodic organic psychosis associated with recurrent herpes simplex . N Engl J Med 271:494-497, 1964.Crossref 14. Carton CA: Effect of previous sensory loss on the appearance of herpes simplex following trigeminal sensory root section . J Neurosurg 10:463-468, 1953.Crossref 15. Baringer JR, Swoveland P: Recovery of herpes simplex virus from human trigeminal ganglions . N Engl J Med 288:648-650, 1973.Crossref 16. Bastian FO, et al: Herpesvirus hominis: Isolation from human trigeminal ganglion . Science 178:306-307, 1972.Crossref 17. Stevens JG, Cook ML: Latent herpes virus in spinal ganglia of mice . Science 173:843-845, 1971.Crossref 18. Kern AB, Schiff BL: Smallpox vaccinations in management of recurrent herpes simplex: Controlled evaluation . J Invest Dermatol 33:99-102, 1959.Crossref 19. Felber TD, et al: Photodynamic inactivation of herpes simplex . JAMA 223:289-292, 1973.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Oct 1, 1974

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