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Asymptomatic Demyelinated Plaque

Asymptomatic Demyelinated Plaque Abstract A clinically silent multiple sclerosis (MS) plaque in the midcervical spinal cord was found unexpectedly at autopsy in a 66-year-old man who died of bronchogenic carcinoma. The patient's history revealed a transient episode of neurological symptoms compatible with an attack of MS more than 30 years prior to death, with no appreciable residual deficits. The discrete anatomical location of this plaque with well-preserved axons emphasizes that the retention of functional integrity of demyelinated axons may be an important factor underlying the poor clinicopathologic correlation in MS. References 1. McAlpine D: The benign form of multiple sclerosis: A study based on 241 cases seen within three years of onset and followed up until the tenth year or more of the disease . Brain 84:186-203, 1961.Crossref 2. Mackay RP, Hirano A: Forms of benign multiple sclerosis: Report of two "clinically silent" cases discovered at autopsy . Arch Neurol 17:588-600, 1967.Crossref 3. Bauer HJ, Frinhaber W: Prognostic criteria in multiple sclerosis . Ann NY Acad Sci 122:542-551, 1965.Crossref 4. Kurtzke JF: Clinical manifestations of multiple sclerosis , in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology . New York, American Elsevier Publishing Co, 1970, vol 9, pp 161-216. 5. Poser CM: Diseases of the myelin sheath , in Merritt HH: A Textbook of Neurology , ed 5, Philadelphia, Lea & Febiger, 1973, pp 683-727. 6. McAlpine D, Lumsden, CE, Acheson ED: Multiple Sclerosis: A Reappraisal , ed 2, Baltimore, Williams & Wilkins Co, 1972. 7. Rose AS, in discussion, Mackay RP, Hirano A: Forms of benign multiple sclerosis with report of two "clinically silent" cases discovered at autopsy . Trans Am Neurol Assoc 92:143-149, 1967. 8. Namerow NS, Thompson LR: Plaques, symptoms, and the remitting course of multiple sclerosis . Neurology 19:765-774, 1969.Crossref 9. Bornstein MB: The immunopathology of de-myelinative disorders examined in organotypic cultures of mammalian central nerve tissue , in Zimmerman HM (ed): Progress in Neuropathology . New York, Grune & Stratton Inc, 1973, vol 2, pp 69-90. 10. Zimmerman HM, Netsky MG: The pathology of multiple sclerosis . Assoc Res Nerv Dis Proc 28:271-312, 1950. 11. Greenfield JG, Norman RM: Demyelinating diseases , in Greenfield's Neuropathology . Baltimore, Williams & Wilkins Co, 1963, pp 475-519. 12. McDonald WI, Sears TA: Effect of demyelination on conduction in the central nervous system . Nature 221:182-183, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1974.00490360060012
Publisher site
See Article on Publisher Site

Abstract

Abstract A clinically silent multiple sclerosis (MS) plaque in the midcervical spinal cord was found unexpectedly at autopsy in a 66-year-old man who died of bronchogenic carcinoma. The patient's history revealed a transient episode of neurological symptoms compatible with an attack of MS more than 30 years prior to death, with no appreciable residual deficits. The discrete anatomical location of this plaque with well-preserved axons emphasizes that the retention of functional integrity of demyelinated axons may be an important factor underlying the poor clinicopathologic correlation in MS. References 1. McAlpine D: The benign form of multiple sclerosis: A study based on 241 cases seen within three years of onset and followed up until the tenth year or more of the disease . Brain 84:186-203, 1961.Crossref 2. Mackay RP, Hirano A: Forms of benign multiple sclerosis: Report of two "clinically silent" cases discovered at autopsy . Arch Neurol 17:588-600, 1967.Crossref 3. Bauer HJ, Frinhaber W: Prognostic criteria in multiple sclerosis . Ann NY Acad Sci 122:542-551, 1965.Crossref 4. Kurtzke JF: Clinical manifestations of multiple sclerosis , in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology . New York, American Elsevier Publishing Co, 1970, vol 9, pp 161-216. 5. Poser CM: Diseases of the myelin sheath , in Merritt HH: A Textbook of Neurology , ed 5, Philadelphia, Lea & Febiger, 1973, pp 683-727. 6. McAlpine D, Lumsden, CE, Acheson ED: Multiple Sclerosis: A Reappraisal , ed 2, Baltimore, Williams & Wilkins Co, 1972. 7. Rose AS, in discussion, Mackay RP, Hirano A: Forms of benign multiple sclerosis with report of two "clinically silent" cases discovered at autopsy . Trans Am Neurol Assoc 92:143-149, 1967. 8. Namerow NS, Thompson LR: Plaques, symptoms, and the remitting course of multiple sclerosis . Neurology 19:765-774, 1969.Crossref 9. Bornstein MB: The immunopathology of de-myelinative disorders examined in organotypic cultures of mammalian central nerve tissue , in Zimmerman HM (ed): Progress in Neuropathology . New York, Grune & Stratton Inc, 1973, vol 2, pp 69-90. 10. Zimmerman HM, Netsky MG: The pathology of multiple sclerosis . Assoc Res Nerv Dis Proc 28:271-312, 1950. 11. Greenfield JG, Norman RM: Demyelinating diseases , in Greenfield's Neuropathology . Baltimore, Williams & Wilkins Co, 1963, pp 475-519. 12. McDonald WI, Sears TA: Effect of demyelination on conduction in the central nervous system . Nature 221:182-183, 1969.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Jun 1, 1974

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