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R. Lindenberg (1956)
Morphotropic and morphostatic necrobiosis; investigations on nerve cells of the brain.The American journal of pathology, 32 6
A. Meyer, M. Falconer, E. Beck (1954)
PATHOLOGICAL FINDINGS IN TEMPORAL LOBE EPILEPSYJournal of Neurology, Neurosurgery & Psychiatry, 17
E. Alvord, J. Loeser, W. Bailey, M. Copass (1972)
Subarachnoid hemorrhage due to ruptured aneurysms. A simple method of estimating prognosis.Archives of neurology, 27 4
A. Gregg (1957)
For Future Doctors
Jaroslava Eolbergrová, V. Macmillan, B. Siesjö (1972)
THE EFFECT OF MODERATE AND MARKED HYPERCAPNIA UPON THE ENERGY STATE AND UPON THE CYTOPLASMIC NADH/NAD+ RATIO OF THE RAT BRAINJournal of Neurochemistry, 19
P. Gatfield, O. Lowry, D. Schulz, J. Passonneau (1966)
REGIONAL ENERGY RESERVES IN MOUSE BRAIN AND CHANGES WITH ISCHAEMIA AND ANAESTHESIA *Journal of Neurochemistry, 13
McDowall Dg (1966)
Interrelationships between blood oxygen tensions and cerebral blood flow.International Anesthesiology Clinics, 4
(1968)
The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope.
rd Ames, R. Wright, M. Kowada, J. Thurston, G. Majno (1968)
Cerebral ischemia. II. The no-reflow phenomenon.The American journal of pathology, 52 2
O. Lowry, J. Passonneau (1964)
THE RELATIONSHIPS BETWEEN SUBSTRATES AND ENZYMES OF GLYCOLYSIS IN BRAIN.The Journal of biological chemistry, 239
K. Hossmann, K. Sato (1971)
Effect of ischaemia on the function of the sensorimotor cortex in cat.Electroencephalography and clinical neurophysiology, 30 6
et al Müller U (1970)
Elektrocortigramm und regionaler Energiestoffwechsel des Kaningehirns in der postisch�mischen ErholungPfluegers Arch, 320
L. Lewis, U. Pontén, B. Siesjö (1973)
Homeostatic regulation of brain energy metabolism in hypoxia.Acta physiologica Scandinavica, 88 2
Noell W (1970)
�ber die Durchblutung und die Sauerstoffversorgung des Gehirns: VI. Mitteilung. Einfluss der Hypoxemie und An�miePfluegers Arch, 247
B. Siesjö, J. Folbergrová, V. Macmillan (1972)
THE EFFECT OF HYPERCAPNIA UPON INTRACELLULAR pH IN THE BRAIN, EVALUATED BY THE BICARBONATE‐ CARBONIC ACID METHOD AND FROM THE CREATINE PHOSPHOKINASE EQUILIBRIUMJournal of Neurochemistry, 19
H. Bachelard, L. Lewis, U. Pontén, B. Siesjö (1974)
MECHANISMS ACTIVATING GLYCOLYSIS IN THE BRAIN IN ARTERIAL HYPOXIAJournal of Neurochemistry, 22
K. Hossmann, Y. Olsson (1970)
Suppression and recovery of neuronal function in transient cerebral ischemia.Brain research, 22 3
B. Siesjö, L. Nilsson (1971)
The influence of arterial hypoxemia upon labile phosphates and upon extracellular and intracellular lactate and pyruvate concentrations in the rat brain.Scandinavian journal of clinical and laboratory investigation, 27 1
O. Lowry, J. Passonneau, F. Hasselberger, D. Schulz (1964)
EFFECT OF ISCHEMIA ON KNOWN SUBSTRATES AND COFACTORS OF THE GLYCOLYTIC PATHWAY IN BRAIN.The Journal of biological chemistry, 239
Stone WE Gurdjian ES (1944)
Cerebral metabolism in hypoxiaArch Neurol Psychiatry, 51
J. Brierley, J. Brierley, A. Brown, A. Brown, J. Excell, J. Excell, Meldrum Bs, Meldrum Bs (1969)
Brain damage in the rhesus monkey resulting from profound arterial hypotension. I. Its nature, distribution and general physiological correlates.Brain research, 13 1
T. Duffy, S. Nelson, O. Lowry (1972)
CEREBRAL CARBOHYDRATE METABOLISM DURING ACUTE HYPOXIA AND RECOVERY 1Journal of Neurochemistry, 19
F. Rolleston, E. Newsholme (1967)
Control of glycolysis in cerebral cortex slices.The Biochemical journal, 104 2
et al Alvord EC Jr (1972)
Subarachnoid hemorrhage due to ruptured aneurysmsArch Neurol, 27
et al Schmahl FW (1966)
Energiestoffwechsel der Grosshirnrinde und Elektroencephalogramm bei SauerstoffmangelPfluegers Arch, 292
Lübbers DW (1968)
Oxygen Transport in Blood and Tissue
U. Pontén, R. Ratcheson, L. Salford, B. Siesjö (1973)
OPTIMAL FREEZING CONDITIONS FOR CEREBRAL METABOLITES IN RATSJournal of Neurochemistry, 21
E. Gurdjian, W. Stone, J. Webster (1944)
CEREBRAL METABOLISM IN HYPOXIAJournal of Nervous and Mental Disease, 51
D. Atkinson (1968)
The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.Biochemistry, 7 11
P. Cohen, S. Alexander, T. Smith, M. Reivich, H. Wollman (1967)
Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man.Journal of applied physiology, 23 2
Lindenberg R (1956)
Morphostatic necrobiosis: Investigations on the nerve cells of the brainAm J Pathol, 32
K. Kogure, P. Scheinberg, O. Reinmuth, M. Fujishima, R. Busto (1970)
Mechanisms of cerebral vasodilatation in hypoxia.Transactions of the American Neurological Association, 94
McDowall DG (1966)
A Symposium on Oxygen Measurements in Blood and Tissues and Their Significance
DH Hinzen, U. Muller, P. Sobotka, E. Gebert, R. Lang, H. Hirsch (1972)
Metabolism and function of dog's brain recovering from longtime ischemia.The American journal of physiology, 223 5
O. Lowry, J. Passonneau (1966)
Kinetic evidence for multiple binding sites on phosphofructokinase.The Journal of biological chemistry, 241 10
Passonneau JV Lowry OH (1972)
A Flexible System of Enzymatic Analysis
R. Bate (1920)
POSTERIOR PITUITARY SECRETION IN THE TREATMENT OF MITRAL REGURGITATIONJournal of Nervous and Mental Disease, 51
V. Macmillan, B. Siesjö (1972)
Brain energy metabolism in hypoxemia.Scandinavian journal of clinical and laboratory investigation, 30 2
et al Kogure K (1970)
Mechanisms of cerebral vasodilation in hypoxiaJ Appl Physiol, 29
Alvord EC Jr (1968)
The Central Nervous System
J. Chiang, M. Kowada, A. rd, R. Wright, G. Majno (1968)
Cerebral ischemia. III. Vascular changes.The American journal of pathology, 52 2
R. Friede, W. Houten (1961)
Relations between postmortem alterations and glycolytic metabolism in the brain.Experimental neurology, 4
Abstract This presentation is intended to summarize information obtained on the energy state of the brain in hypoxia (low arterial oxygen pressure [Po2]) and in ischemia (interruption of the cerebral circulation). The discussion is directed to the following questions: (1) At what arterial and cerebral venous Po2 levels are there changes indicating a derangement of cerebral energy metabolism? (2) What is the metabolic picture in complete ischemia, and when does energy depletion occur? (3) Is there complete restitution of energy metabolism even after prolonged ischemia, or are there postischemic changes indicative of a permanent biochemical lesion? (4) Can the biochemical data reveal the presence of unperfused areas? The results were obtained on lightly anesthetized and artificially ventilated rats in which body temperature, arterial blood pressure, and arterial Po2, carbon dioxide pressure (Pco2), and pH were monitored. Cerebral metabolites were analyzed after freezing the tissue in situ, using the References 1. Lowry OH, Passonneau JV: A Flexible System of Enzymatic Analysis . New York, Academic Press, 1972. 2. Folbergrová J, MacMillan V, Siesjö BK: The effect of moderate and marked hypercapnia upon the energy state and upon the cytoplasmatic NADH/NAD+ ratio of the rat brain . J Neurochem 19:2497-2505, 1972.Crossref 3. Pontén U, et al: Optimal freezing conditions for cerebral metabolites in rats . J Neurochem , to be published. 4. Siesjö BK, Folbergrová J, MacMillan V: The effect of hypercapnia upon intracellular pH in the brain, evaluated by the bicarbonate-carbonic acid method and from the creatine phosphokinase equilibrium . J Neurochem 19:2483-2495, 1972.Crossref 5. Cohen PJ, et al: Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man . J Appl Physiol 23:183-189, 1967. 6. 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Archives of Neurology – American Medical Association
Published: Dec 1, 1973
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