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Essential Hypernatremia: The Experimental Model

Essential Hypernatremia: The Experimental Model Abstract A syndrome of sustained elevation of serum sodium and osmolality was produced in cats by injecting 5% silver nitrate (AgNO3) into the perichiasmatic subarachnoid cisterns. Metabolic balance studies showed no significant differences between preoperative and postoperative body weight, urine osmolality, water intake, or urine output. Injury to the supraoptic nucleus of the hypothalamus correlated well with the development of the hypernatremic, hyperosmotic state. References 1. Allott EN: Sodium and chloride retention without renal disease . Lancet 1:1035-1037, 1939.Crossref 2. Sweet WH, et al: Gastrointestinal hemorrhages, hyperglycemia, azotemia, hyperchloremia, and hypernatremia following lesions of frontal lobe in man . Res Publ Assoc Res Nerv Ment Dis 27:795-822, 1948. 3. MacCarty CS, Cooper IS: Neurologic and metabolic effects of bilateral ligation of the anterior cerebral arteries in man . Mayo Clin Proc 26:185-190, 1951. 4. Zierler KL: Hyperosmolality in adults: A critical review . J Chronic Dis 7:1-23, 1958.Crossref 5. Hayes RM, McHugh PR, Williams HE: Absence of thirst in association with hydrocephalus . New Engl J Med 269:227-231, 1963.Crossref 6. Kastin AJ, et al: Asymptomatic hypernatremia: Physiological and clinical study . Am J Med 38:306-315, 1965.Crossref 7. Pleasure D, Goldberg M: Neurogenic hypernatremia . Arch Neurol 15:78-87, 1966.Crossref 8. Welt LG: Hypo- and hypernatremia . Ann Intern Med 56:161-164, 1962.Crossref 9. McLean AJ: Transbuccal approach to encephalon in experimental operations upon carnivoral pituitary, pons, and ventral medulla . Ann Surg 88:985-993, 1928.Crossref 10. Halmi NS: and Davies J: Comparison of aldehyde fuchsin straining, metachromasia, and periodic acid-Schiff reactivity of various tissues . J Histochem Cytochem 1:447-459, 1953.Crossref 11. Lewy FH, Gassman FK: Experiments on the hypothalamic nuclei in the regulation of chloride and sugar metabolism . Am J Physiol 112:504-510, 1935. 12. Stevenson JAF, Welt LG, Orloff J: Abnormalities of water and electrolyte metabolism in rats with hypothalamic lesions . Am J Physiol 161:35-39, 1950. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Essential Hypernatremia: The Experimental Model

Dorn, Janice; Rothballer, Alan B.
Archives of Neurology , Volume 28 (2) – Feb 1, 1973
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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1973.00490200031003
Publisher site
See Article on Publisher Site

Abstract

Abstract A syndrome of sustained elevation of serum sodium and osmolality was produced in cats by injecting 5% silver nitrate (AgNO3) into the perichiasmatic subarachnoid cisterns. Metabolic balance studies showed no significant differences between preoperative and postoperative body weight, urine osmolality, water intake, or urine output. Injury to the supraoptic nucleus of the hypothalamus correlated well with the development of the hypernatremic, hyperosmotic state. References 1. Allott EN: Sodium and chloride retention without renal disease . Lancet 1:1035-1037, 1939.Crossref 2. Sweet WH, et al: Gastrointestinal hemorrhages, hyperglycemia, azotemia, hyperchloremia, and hypernatremia following lesions of frontal lobe in man . Res Publ Assoc Res Nerv Ment Dis 27:795-822, 1948. 3. MacCarty CS, Cooper IS: Neurologic and metabolic effects of bilateral ligation of the anterior cerebral arteries in man . Mayo Clin Proc 26:185-190, 1951. 4. Zierler KL: Hyperosmolality in adults: A critical review . J Chronic Dis 7:1-23, 1958.Crossref 5. Hayes RM, McHugh PR, Williams HE: Absence of thirst in association with hydrocephalus . New Engl J Med 269:227-231, 1963.Crossref 6. Kastin AJ, et al: Asymptomatic hypernatremia: Physiological and clinical study . Am J Med 38:306-315, 1965.Crossref 7. Pleasure D, Goldberg M: Neurogenic hypernatremia . Arch Neurol 15:78-87, 1966.Crossref 8. Welt LG: Hypo- and hypernatremia . Ann Intern Med 56:161-164, 1962.Crossref 9. McLean AJ: Transbuccal approach to encephalon in experimental operations upon carnivoral pituitary, pons, and ventral medulla . Ann Surg 88:985-993, 1928.Crossref 10. Halmi NS: and Davies J: Comparison of aldehyde fuchsin straining, metachromasia, and periodic acid-Schiff reactivity of various tissues . J Histochem Cytochem 1:447-459, 1953.Crossref 11. Lewy FH, Gassman FK: Experiments on the hypothalamic nuclei in the regulation of chloride and sugar metabolism . Am J Physiol 112:504-510, 1935. 12. Stevenson JAF, Welt LG, Orloff J: Abnormalities of water and electrolyte metabolism in rats with hypothalamic lesions . Am J Physiol 161:35-39, 1950.

Journal

Archives of Neurology – American Medical Association

Published: Feb 1, 1973

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