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Experimental Core-Like Lesions and Nemaline Rods: A Correlative Morphological and Physiological Study

Experimental Core-Like Lesions and Nemaline Rods: A Correlative Morphological and Physiological... Abstract Core-like lesions and nemaline rods were produced in type I extrafusal muscle fibers of rat soleus by Achilles tenotomy. In tenotomized solei the aggregate of motor unit activity was reduced. The continuous pattern of motor unit activity characterizing normal soleus was changed to a phasic pattern. Sciatic neurotomy or thoracic cordotomy at the time of tenotomy prevented the lesions and abolished motor unit activity in the soleus for a few days. Neuronal activation of muscle fibers appears essential for the development of core-like lesions and rods. Recoil of tenotomized muscle also seems necessary. The experimental central lesions resemble and differ from human central cores and targets. Experimental and human nemaline rods are morphologically indistinguishable. A common pathogenic mechanism in the formation of the human and the experimental lesions was not identified. References 1. Engel WK, Brooke MH, Nelson PG: Histochemical studies of denervated or tenotomized cat muscle . Ann NY Acad Sci 138:160-185, 1966.Crossref 2. Resnick JS, Engel WK, Nelson PG: Changes in the Z disc of skeletal muscle induced by tenotomy . Neurology 18:737-740, 1968.Crossref 3. Shafiq SA, Gorycki MA, Asiedu SA, et al: Tenotomy: Effect on the fine structure of the soleus of the rat . Arch Neurol 20:625-633, 1969.Crossref 4. Karpati G, Carpenter S, Andermann F: A new concept of childhood nemaline myopathy . Arch Neurol 24:291-304, 1971.Crossref 5. Karpati G, Engel WK: Correlative histochemical study of skeletal muscle after suprasegmental denervation, peripheral nerve section and skeletal fixation . Neurology 18:681-692, 1968.Crossref 6. Fischbach GD, Robbins N: Changes in contratile properties of disused soleus muscle . J Physiol 201:305-320, 1969. 7. Clarke J, Karpati G, Carpenter S, et al: The effect of vincristine on skeletal muscle in the rat , J Neuropath Exp Neurol 31:247-266, 1972.Crossref 8. Kopriwa BM, Leblond CP: Improvements in the coating technique of radioautography . J Histochem Cytochem 10:269-284, 1962.Crossref 9. Brooke MH, Kaiser KK: Muscle fiber typer: How many and what kind? Arch Neurol 23:369-370, 1970.Crossref 10. Engel AG: Pathological reactions of the Z disc , in Milhorat AT (ed): Exploratory Concepts in Muscular Dystrophy and Related Disorders . Amsterdam, Excerpta Medica Foundation, 1967, pp 398-411. 11. Engel AG, Gomez MR, Groover RV: Multicore disease: A recently recognized cogenital myopathy associated with multifocal degeneration of muscle fibers . Mayo Clin Proc 46:666-681, 1971. 12. Afifi AK, Smith JW, Zellweger H: Congenital nonprogressive myopathy: Central core disease and nemaline myopathy in one family . Neurology 15:371-381, 1965.Crossref 13. Schotland DL: An electron microscopic study of target fibers, target-like fibers and related abnormalities in human muscle . J Neuropath Exp Neurol 28:214-228, 14. Resnick JS, Engel WK: Target fibers: Structural andcytochemical characteristics and their relationship to neurogenic muscle disease and fiber types , in Milhorat AT (ed): Exploratory Concepts in Muscular Dystrophy and Related Disorders . Amsterdam, Excerpta Medica Foundation, 1967, pp 255-267. 15. Vrbová G: The effect of moto-neurone activity on the speed of contraction of striated muscle . J Physiol 169:513-526, 1963. 16. Nelson PG: Functional consequences of tenotomy in hind limb muscles of the cat . J Physiol 201:321-333, 1969. 17. Hogenhuis LAH, Engel WK: Histochemistry and cytochemistry of experimentally denervated guinea pig muscle . Acta Anat 60:39-65, 1965.Crossref 18. Taylor SR, Rudel R: Striated muscle fibers: Inactivation of contraction induced by shortening . Science 167:882-884, 1970.Crossref 19. Schiaffino S, Hanzilkova V, Pierbou S: Relations between structure and function in rat skeletal muscle fibers . J Cell Biol 47:109-119, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Experimental Core-Like Lesions and Nemaline Rods: A Correlative Morphological and Physiological Study

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1972.00490150045008
Publisher site
See Article on Publisher Site

Abstract

Abstract Core-like lesions and nemaline rods were produced in type I extrafusal muscle fibers of rat soleus by Achilles tenotomy. In tenotomized solei the aggregate of motor unit activity was reduced. The continuous pattern of motor unit activity characterizing normal soleus was changed to a phasic pattern. Sciatic neurotomy or thoracic cordotomy at the time of tenotomy prevented the lesions and abolished motor unit activity in the soleus for a few days. Neuronal activation of muscle fibers appears essential for the development of core-like lesions and rods. Recoil of tenotomized muscle also seems necessary. The experimental central lesions resemble and differ from human central cores and targets. Experimental and human nemaline rods are morphologically indistinguishable. A common pathogenic mechanism in the formation of the human and the experimental lesions was not identified. References 1. Engel WK, Brooke MH, Nelson PG: Histochemical studies of denervated or tenotomized cat muscle . Ann NY Acad Sci 138:160-185, 1966.Crossref 2. Resnick JS, Engel WK, Nelson PG: Changes in the Z disc of skeletal muscle induced by tenotomy . Neurology 18:737-740, 1968.Crossref 3. Shafiq SA, Gorycki MA, Asiedu SA, et al: Tenotomy: Effect on the fine structure of the soleus of the rat . Arch Neurol 20:625-633, 1969.Crossref 4. Karpati G, Carpenter S, Andermann F: A new concept of childhood nemaline myopathy . Arch Neurol 24:291-304, 1971.Crossref 5. Karpati G, Engel WK: Correlative histochemical study of skeletal muscle after suprasegmental denervation, peripheral nerve section and skeletal fixation . Neurology 18:681-692, 1968.Crossref 6. Fischbach GD, Robbins N: Changes in contratile properties of disused soleus muscle . J Physiol 201:305-320, 1969. 7. Clarke J, Karpati G, Carpenter S, et al: The effect of vincristine on skeletal muscle in the rat , J Neuropath Exp Neurol 31:247-266, 1972.Crossref 8. Kopriwa BM, Leblond CP: Improvements in the coating technique of radioautography . J Histochem Cytochem 10:269-284, 1962.Crossref 9. Brooke MH, Kaiser KK: Muscle fiber typer: How many and what kind? Arch Neurol 23:369-370, 1970.Crossref 10. Engel AG: Pathological reactions of the Z disc , in Milhorat AT (ed): Exploratory Concepts in Muscular Dystrophy and Related Disorders . Amsterdam, Excerpta Medica Foundation, 1967, pp 398-411. 11. Engel AG, Gomez MR, Groover RV: Multicore disease: A recently recognized cogenital myopathy associated with multifocal degeneration of muscle fibers . Mayo Clin Proc 46:666-681, 1971. 12. Afifi AK, Smith JW, Zellweger H: Congenital nonprogressive myopathy: Central core disease and nemaline myopathy in one family . Neurology 15:371-381, 1965.Crossref 13. Schotland DL: An electron microscopic study of target fibers, target-like fibers and related abnormalities in human muscle . J Neuropath Exp Neurol 28:214-228, 14. Resnick JS, Engel WK: Target fibers: Structural andcytochemical characteristics and their relationship to neurogenic muscle disease and fiber types , in Milhorat AT (ed): Exploratory Concepts in Muscular Dystrophy and Related Disorders . Amsterdam, Excerpta Medica Foundation, 1967, pp 255-267. 15. Vrbová G: The effect of moto-neurone activity on the speed of contraction of striated muscle . J Physiol 169:513-526, 1963. 16. Nelson PG: Functional consequences of tenotomy in hind limb muscles of the cat . J Physiol 201:321-333, 1969. 17. Hogenhuis LAH, Engel WK: Histochemistry and cytochemistry of experimentally denervated guinea pig muscle . Acta Anat 60:39-65, 1965.Crossref 18. Taylor SR, Rudel R: Striated muscle fibers: Inactivation of contraction induced by shortening . Science 167:882-884, 1970.Crossref 19. Schiaffino S, Hanzilkova V, Pierbou S: Relations between structure and function in rat skeletal muscle fibers . J Cell Biol 47:109-119, 1970.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Sep 1, 1972

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