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G. Wallenius (1952)
Electrophoretic patterns of cerebrospinal fluid and serum compared in normal and pathological conditions.Acta Societatis Medicorum Upsaliensis, 57 3-4
Hällén J (1966)
Discrete gammaglobulin (M-) components in serumActa Med Scand, 179
R. Grelland (2009)
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E. Kabat, D. Moore, H. Landow (1942)
AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS.The Journal of clinical investigation, 21 5
Kabat Ea, Freedman Da (1950)
A study of the crystalline albumin, gamma globulin and total protein in the cerebrospinal fluid of 100 cases of multiple sclerosis and in other diseases.The American Journal of the Medical Sciences, 219
Goldensohn SS Yahr MD (1954)
Further studies on the gamma globulin content of cerebrospinal fluid in multiple sclerosis and other neurological diseasesAnn NY Acad Sci, 58
R. Norberg (2009)
The immunoglobulin content of normal serum.Acta medica Scandinavica, 181 4
E. Frick, L. SCHEID-SEYDEL (1958)
[Studies with gamma globulin labeled with radioiodine on the origin of protein bodies in the cerebrospinal fluid].Klinische Wochenschrift, 36 18
A. Weiss, E. Smith, N. Christoff, S. Kochwa (1965)
CEREBROSPINAL FLUID PARAPROTEINS IN MULTIPLE MYELOMA.The Journal of laboratory and clinical medicine, 66
Heremans JF Laterre EC (1962)
La pathologie des protéines du liquide céphalo-rachidienRev Neurol, 107
C. MacPherson, J. Cosgrove (1968)
An unusual IgG globulin. Frequency of occurrence in cerebrospinal fluid in multiple sclerosis.Archives of neurology, 19 5
U. Rinne, P. Riekkinen (1968)
ESTERASE, PEPTIDASE AND PROTEINASE ACTIVITIES OF HUMAN CEREBROSPINAL FLUID IN MULTIPLE SCLEROSISActa Neurologica Scandinavica, 44
Plum CM Lous P (1956)
Colorimetric determination of total protein and globulin in cerebrospinal fluidNord Med, 55
A. Ferraro (1958)
STUDIES ON MULTIPLE SCLEROSIS: I. MULTIPLE SCLEROSIS VIEWED AS A “CHRONIC DISSEMINATED ENCEPHALOMYELITIS”. II. ETIO‐PATHOGENESIS OF MULTIPLE SCLEROSIS (INFECTIOUS ALLERGIC OR TOXIC ALLERGIC)Journal of Neuropathology and Experimental Neurology, 17
T. Hartley, D. Merrill, H. Claman (1966)
Quantitation of immunoglobulins in cerebrospinal fluid.Archives of neurology, 15 5
Müller R (1949)
Studies on multiple sclerosisActa Med Scand, 133
Frick E (1959)
Immunophoretische Untersuchungen am Liquor cerebrospinalisKlin Wschr, 37
E. AUBERT (1950)
[Cerebrospinal fluid in diagnosis].Medicina, 30 600
Bannister R Cohen S (1967)
Immunoglobulin synthesis within the central nervous system in multiple sclerosisLancet, 1
C. Uyeda, B. Gerstl, L. Eng, J. Smith (1969)
Serum Immunoglobulins in Multiple Sclerosis Patients∗Proceedings of the Society for Experimental Biology and Medicine, 131
H. Link (1967)
Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid. Chemical and immunological characterisation with special reference to multiple sclerosis.Acta neurologica Scandinavica, 43
Heremans JF Michaux J-L (1969)
Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemiaAmer J Med, 46
S. Dencker (1964)
IMMUNO‐ELECTROPHORETIC INVESTIGATION OF CEREBROSPINAL FLUID γ‐GLOBULINS IN MULTIPLE SCLEROSISActa Neurologica Scandinavica, 40
D. Riddoch, R. Thompson (1970)
Immunoglobulin Levels in the Cerebrospinal FluidBritish Medical Journal, 1
Zettervall O Link H (1969)
Second International Meeting of the International Society for Neurochemistry
K. Cramér, O. Vikrot (2009)
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Gottesleben A Bauer HJ (1969)
Quantitative immunochemical studies of cerebrospinal fluid proteins in relation to clinical activity of multiple sclerosis, in Pathogenesis and etiology of demyelinating diseasesInt Arch Allerg, 36
W. Penfield (1967)
EPILEPSY, THE GREAT TEACHERActa Neurologica Scandinavica, 43
Freedman Da, Merritt Hh (1950)
The cerebrospinal fluid in multiple sclerosis.Research publications - Association for Research in Nervous and Mental Disease, 28
J. Michaux, J. Heremans (1969)
Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemia. A classification of diseases associated with the production of monoclonal-type immunoglobulins.The American journal of medicine, 46 4
Scheid-Seydel L Frick E (1958)
Untersuchungen mit J131-markiertem γ-Globulin zur Frage der Abstammung der LiquoreiweisskörperKlin Wschr, 36
S. Schneck, H. Claman (1969)
CSF immunoglobulins in multiple sclerosis and other neurologic diseases. Measurement by electroimmunodiffusion.Archives of neurology, 20 2
E. Kabat, M. Glusman, V. Knaub (1948)
Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods.The American journal of medicine, 4 5
M. Yahr, S. Goldensohn, E. Kabat (1954)
FURTHER STUDIES ON THE GAMMA GLOBULIN CONTENT OF CEREBROSPINAL FLUID IN MULTIPLE SCLEROSIS AND OTHER NEUROLOGICAL DISEASESAnnals of the New York Academy of Sciences, 58
E. Laterre, A. Callewaert, J. Heremans, Z. Sfaello (1970)
Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous systemNeurology, 20
H. Link, O. Zettervall (1970)
Multiple sclerosis: disturbed kappa: lambda chain ratio of immunoglobulin G in cerebrospinal fluid.Clinical and experimental immunology, 6 3
Charles Goldberg, F. Whitehouse (1970)
F(ab′)2-like Fragments from Severely Burned Patients provide a New Serum Immunoglobin ComponentNature, 228
Link H Zettervall O (1970)
Electrophoretic distribution of kappa and lambda immunoglobulin light chain determinants in serum and CSF in multiple sclerosisClin Exp Immun, 7
Abstract Increased relative cerebrospinal fluid (CSF) concentrations of immunoglobulin G, immunoglobulin A, and immunoglobulin M were found in 73%, 9%, and 0% of 64 multiple sclerosis (MS) patients, in 36%, 27%, and 9% of 39 patients with central nervous system (CNS) infections, and in 16%, 14%, and 6% of 81 patients with other neurological disorders, when compared with 30 controls. Oligoclonal CSF-immunoglobulin G in the form of discrete bands on agar gel electrophoresis and abnormal kappa:lambda immunoglobulin light chain ratio was found in 94% and 53% in MS, in 39% and 0% in CNS infections, and in 3% and 3% in other neurological disorders. Immunoelectrophoresis abnormalities of the CSF-immunoglobulin G precipitation line were found in all three patient groups. The corresponding serum investigations were nearly always normal. The MS-CSF abnormalities were correlated to different clinical factors. References 1. Kabat EA, Glusman M, Knaub V: Quantitative estimation of the albumin and gammaglobulin in normal and pathologic cerebrospinal fluid by immunochemical methods . Amer J Med 4:653-662, 1948.Crossref 2. Kabat EA, Freedman DA, Murray JP, et al: A study of the crystalline albumin, gamma globulin and total protein in the cerebrospinal fluid of one hundred cases of multiple sclerosis and in other diseases . Amer J Med Sci 219:55-64, 1950.Crossref 3. Yahr MD, Goldensohn SS, Kabat EA: Further studies on the gamma globulin content of cerebrospinal fluid in multiple sclerosis and other neurological diseases . Ann NY Acad Sci 58:613-624, 1954.Crossref 4. Hartley TF, Merrill DA, Claman HN: Quantitation of immunoglobulins in cerebrospinal fluid . Arch Neurol 15:472-479, 1966.Crossref 5. Bauer HJ, Gottesleben A: Quantitative immunochemical studies of cerebrospinal fluid proteins in relation to clinical activity of multiple sclerosis, in Pathogenesis and etiology of demyelinating diseases . Int Arch Allerg 36:643-648, 1969. 6. Kabat EA, Moore DH, Landow H: An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins . J Clin Invest 21:571-577, 1942.Crossref 7. Uyeda CT, Gerstl B, Eng LF, et al: Serum immunoglobulins in multiple sclerosis patients . Proc Soc Exp Biol Med 131:1138-1141, 1969.Crossref 8. Frick E: Immunophoretische Untersuchungen am Liquor cerebrospinalis . Klin Wschr 37:645-651, 1959.Crossref 9. Laterre EC, Heremans JF, Demanet G: La pathologie des protéines du liquide céphalo-rachidien . Rev Neurol 107:500-521, 1962. 10. Link H: Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid: Chemical and immunological characterisation with special reference to multiple sclerosis . Acta Neurol Scand 43( (suppl 28) ):1-136, 1967. 11. Laterre EC, Callewaert A, Heremans JF, et al: Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system . Neurology 20:982-990, 1970.Crossref 12. Link H, Zettervall O: Multiple Sclerosis: Disturbed kappa:lambda light chain ratio of immunoglobulin G in cerebrospinal fluid . Clin Exp Immun 6:435-438, 1970. 13. Müller R: Studies on multiple sclerosis . Acta Med Scand 133( (suppl 222) ):1-214, 1949. 14. Norberg R: The immunoglobulin content of normal serum . Acta Med Scand 181:485-496, 1967.Crossref 15. Lous P, Plum CM, Schou M: Colorimetric determination of total protein and globulin in cerebrospinal fluid . Nord Med 55:693-695, 1956. 16. Schneck SA, Claman HN: CSF immunoglobulins in multiple sclerosis and other neurologic diseases: Measurement by electroimmunodiffusion . Arch Neurol 20:132-139, 1969.Crossref 17. Riddoch D, Thompson RA: Immunoglobulin levels in the cerebrospinal fluid . Brit Med J 1:396-399, 1970.Crossref 18. Link H, Zettervall O: Increased cerebrospinal fluid (CSF) total protein, a sign of blood CSF-barrier damage: Report , in Paoletti R (ed): Second International Meeting of the International Society for Neurochemistry . Milan, Italy, Tamburini Editore, 1969, pp 269-270. 19. Cohen S, Bannister R: Immunoglobulin synthesis within the central nervous system in multiple sclerosis . Lancet 1:366-367, 1967.Crossref 20. Frick E, Scheid-Seydel L: Untersuchungen mit J131-markiertem γ-Globulin zur Frage der Abstammung der Liquoreiweisskörper . Klin Wschr 36:857-863, 1958.Crossref 21. Zettervall O, Link H: Electrophoretic distribution of kappa and lambda immunoglobulin light chain determinants in serum and CSF in multiple sclerosis . Clin Exp Immun 7:365-372, 1970. 22. Dencker J: Immunoelectrophoretic investigation of cerebrospinal fluid γ-globulins in multiple sclerosis . Acta Neurol Scand 40 ( (suppl 10) ):57-64, 1964.Crossref 23. MacPherson CFC, Cosgrove JBR: An unusual IgG globulin: Frequency of occurrence in cerebrospinal fluid in multiple sclerosis . Arch Neurol 19:503-509, 1968.Crossref 24. Goldberg CB, Whitestone F: F (ab1) 2-like fragments from severely burned patients provide a new serum immunoglobulin component . Nature 228:160-162, 1970.Crossref 25. Rinne UK, Riekkinen P: Esterase, peptidase and proteinase activities of human cerebrospinal fluid in multiple sclerosis . Acta Neurol Scand 44:156-167, 1968.Crossref 26. Wallenius G: Electrophoretic patterns of cerebrospinal fluid and serum compared in normal and pathological conditions . Acta Soc Med Upsal 57:138-146, 1952. 27. Weiss AH, Smith E, Cristoff N, et al: Cerebrospinal fluid paraproteins in multiple myeloma . J Lab Clin Med 66:280-293, 1965. 28. Michaux J-L, Heremans JF: Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemia . Amer J Med 46: 562-579, 1969.Crossref 29. Hällén J: Discrete gammaglobulin (M-) components in serum . Acta Med Scand 179( (suppl 462) ):1-427, 1966. 30. Cumings JN: The cerebrospinal fluid in diagnosis . Brit Med J 1:449-451, 1954.Crossref 31. Freedman DA, Merritt HH: The cerebrospinal fluid in multiple sclerosis . Res Publ Assoc Res Nerv Ment Dis 28:428-439, 1950.
Archives of Neurology – American Medical Association
Published: Oct 1, 1971
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