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W.H. McMenemey , H.C. Grant, S. and Behrman (1965)
Two Examples of "Pre-senile Dementia" (Pick's Disease and Stern-Garcin Syndrome), With a History of TraumaArch Psychiat Nervenkr, 207
J.F. Dingman (1962)
Abnormal N-ural Regulation of Vasopressin and Aldosterone Secretion in a Patient With Cerebral HyponatremiaJ Clin Invest, 41
G. McGovern, D. Miller, E. Robertson (1959)
A mental syndrome associated with lung carcinoma.A.M.A. archives of neurology and psychiatry, 81 3
D. Denny-Brown (1948)
PRIMARY SENSORY NEUROPATHY WITH MUSCULAR CHANGES ASSOCIATED WITH CARCINOMAJournal of Neurology, Neurosurgery & Psychiatry, 11
W.R. Kirschbaum (1968)
Jakob-Creutzfeldt Disease
G. Ludwig, M. Goldberg (1963)
HYPONATREMIA IN ACUTE INTERMITTENT PORPHYRIA PROBABLY RESULTING FROM INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE *Annals of the New York Academy of Sciences, 104
V. Wynn (1956)
Water intoxication and serum hypotonicity.Metabolism: clinical and experimental, 5 4
R.L. Rovit (1964)
Hyponatremia With Herpes Simplex EncephalitisArch Neurol, 10
K. Stern (1939)
SEVERE DEMENTIA ASSOCIATED WITH BILATERAL SYMMETRICAL DEGENERATION OF THE THALAMUSBrain, 62
R. Henson, H. Hoffman, H. Urich (1965)
Encephalomyelitis with carcinoma.Brain : a journal of neurology, 88 3
W. May (1968)
CREUTZFELDT‐JAKOB DISEASE; 1. Survey of The Literature and Clinical DiagnosisActa Neurologica Scandinavica, 44
W.W. May (1968)
Creutzfeldt-Jakob DiseaseActa Neurol Scand, 44
M. Yahr, R. Duvoisin, D. Cowen (1965)
Encephalopathy associated with carcinoma.Transactions of the American Neurological Association, 90
Simenon Locke (1967)
Thalamic connections to insular and opercular cortex of monkeyJournal of Comparative Neurology, 129
G.P. McGovern , D.H. Miller, E.E. and Robertson (1959)
A Mental Syndrome Associated With Lung CarcinomaArch Neurol Psychiat, 81
R. Garcin , S. Brion, A.A. and Khochnevis (1963)
Le syndrome de creutzfeldt-Jakob et les syndromes cortico-stries du presenium (a l'occasion de 5 observations anatomo-cliniques)Rev Neurol, 109
G.M. Zurhein (1967)
Polyoma Like Virus in a Human Demyelinating DiseaseActa Neuropath, 8
E. Bickerstaff, E. Elabute, A. Woolf (1966)
Severe cerebral degeneration associated with primary hepatic carcinomaJournal of Neurology, Neurosurgery & Psychiatry, 29
A. Dayan, P. Croft, M. Wilkinson (1965)
Association of carcinomatous neuromyopathy with different histological types of carcinoma of the lung.Brain : a journal of neurology, 88 3
J.B. Posner (1967)
Hyponatremia in Acute PolyneuropathyArch Neurol, 17
J. Corsellis, G. Goldberg, A. Norton (1968)
"Limbic encephalitis" and its association with carcinoma.Brain : a journal of neurology, 91 3
L. Barraquer-Bordas (1967)
Sur une necorse thalamique avec meningoependymite subaigue contribution a l'etude des troubles psychiques d'origine mesencephalothalmiqueActa Neurol Belg, 67
F.C. Bartter (1967)
The Syndrome of Inappropriate Secretion of Anti-diuretic HormoneAmer J Med, 42
P. Croft, R. Henson, H. Urich, P. Wilkinson (1965)
Sensory neuropathy with bronchial carcinoma: a study of four cases showing serological abnormalities.Brain : a journal of neurology, 88 3
P. Croft, M. Wilkinson (1965)
The incidence of carcinomatous neuromyopathy in patients with various types of carcinoma.Brain : a journal of neurology, 88 3
J. Hayward, W. Smith (1963)
INFLUENCE OF LIMBIC SYSTEM ON NEUROHYPOPHYSIS.Archives of neurology, 9
A. Hirano (1962)
Silver Impregnation of Nerve Cells and Fibers in Celloidin SectionsArch Neurol, 6
G.D. Ludwig (1963)
Hvponatremia in Acute Intermittent Porphyria Probably Resulting From Inappropriate Secretion of Antidiuretic HormoneAnn NY Acad Sci, 104
J. Nelson, R. Woolsey, G. Broun (1966)
CORTICAL DEGENERATION ASSOCIATED WITH MYELOMA AND DEMENTIAJournal of Neuropathology and Experimental Neurology, 25
E. Hutchinson, B. Leonard, C. Maudsley, P. Yates (1958)
Neurological complications of the reticuloses.Brain : a journal of neurology, 81 1
F. Charatan, J. Brierley (1956)
Mental Disorder Associated with Primary Lung CarcinomaBritish Medical Journal, 1
B. Wise (1968)
Inappropriate secretion of ADH caused by obstruction of ventriculoatrial shunts.Journal of neurosurgery, 28 5
B.R.: " Kaada (1960)
Handbook of Physiology: Section I. Neurophysiology, 2
C. Sethurajan , P.B. Croft, M. and Wilkinson (1967)
Bronchial Neoplasm With Endocrine, Metabolic and Neurological ManifestationsNeurology, 17
H. Vorherr, S. Massry, R. Utiger, C. Kleeman (1968)
Antidiuretic principle in malignant tumor extracts from patients with inappropriate ADH syndrome.The Journal of clinical endocrinology and metabolism, 28 2
E. Grunthal (1942)
Uber Thalamische DemenzMschr Psychiat Neurol, 106
S. Yokoi (1957)
NEUROPATHOLOGICAL STUDY OF PREFRONTAL LOBOTOMYJournal of Neuropathology and Experimental Neurology, 16
A.: " Meyer (1963)
Greenfield's Neuropathology
M.: " Victor (1965)
The Remote Effects of Cancer on the Nervous System
J. Wells (1966)
The pathway from the dorsomedial thalamus to the frontal lobe.Experimental neurology, 14 3
J.B. Dosseter , E.H. Venning, J.C. and Beck (1961)
Hyponatremia Associated with Superior Vena Cava ObstructionMetabolism, 10
P. Castaigne (1966)
Demence thalamique d'origine vasculaire par ramollissement bilateral, limite au territoire de pedicle retro mamillaire: A propos de deux observatious anatomo-cliniquesRev Neurol, 114
W. Schwartz, Warren Bennett, S. Curelop, F. Bartter (1957)
A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone.The American journal of medicine, 23 4
W. Kirschbaum (1968)
Jakob-Creutzfeldt disease : spastic pseudosclerosis, A. Jakob; Heidenhain syndrome; subacute spongiform encephalopathy
H. Gastaut, R. Naquet, M. Fischer-Williams (1958)
The pathophysiology of grand mal seizures generalized from the start.The Journal of nervous and mental disease, 127 1
W.R. Cheek (1966)
Thalamic TumorsJ Neurosurg, 24
S. Schulman (1957)
BILATERAL SYMMETRICAL DEGENERATION OF THE THALAMUS: A CLINICO‐PATHOLOGICAL STUDYJournal of Neuropathology and Experimental Neurology, 16
J. Cort (1954)
Cerebral salt wasting.Lancet, 266 6815
E. Grünthal (1942)
Über thalamische DemenzEuropean Neurology, 106
J.J. Martin (1966)
Troubles psychiques dans une atrophie primitive des noyaux thalamiques dorsomediansRev Neurol, 114
S. Mullan (1967)
Thalamic Lesions for the Control of EpilepsyArch Neurol, 16
J. Carman, W. Cowan, T. Powell (1964)
The cortical projection upon the claustrum1Journal of Neurology, Neurosurgery & Psychiatry, 27
E. Richardson (1961)
Progressive multifocal leukoencephalopathy.The New England journal of medicine, 265
E. Crosby, Humphrey Tryphena, E. Lauer, J. Kappers (1962)
Correlative Anatomy of the Nervous System
L. Brain, M. Wilkinson (1965)
Subacute cerebellar degeneration associated with neoplasms.Brain : a journal of neurology, 88 3
J. Ulrich , H. Spiess, R. and Huber (1967)
Neurologische Syndrome als Fernwirkung Maligner Tumoren (Ammonshornsklerose bei Bronchuskarzinom)Schweiz Arch Neurol Neurochir Psychiat, 99
D. Williams (1965)
The thalamus and epilepsy.Brain : a journal of neurology, 88 3
J.J. Martin (1967)
Sur une degenerescence systematise de centre medianJ Hirnforsch, 9
C. Vanderwolf (1968)
Recovery from large medial thalamic lesions as a result of electroconvulsive therapy.Journal of Neurology, Neurosurgery & Psychiatry, 31
R. Brain, R. Henson (1958)
Neurological syndromes associated with carcinoma: the carcinomatous neuromyopathies.Lancet, 2 7054
W.R. Kennedy (1968)
The Myasthenic Syndrome Associated With Small Cell Carcinoma of the LungNeurology, 18
T. McLardy (1950)
Thalamic Projection to the Frontal Cortex in ManJ Neurol Neurosurg Psychiat, 13
J.J. Martin (1966)
Topographie et signification des lesions thalamiques dans la maladie Creutzfeldt-Jakob et les formes apparenteesJ Hirnforsch, 8
Abstract ATIENTS harboring malignant neoplasms may develop neurological and endocrinological disorders in the absence of metastases to the nervous system or endocrine glands.1 The resulting clinical syndromes have been referred to as the "remote" or "nonmetastatic" effects of malignant tumors. The exact incidence of these complications has not been determined. Croft and Wilkinson2 state that nonmetastatic neurological syndromes develop in 2% to 16% of carcinomas, and of these, 65% are neuromuscular in type. The incidence of neurological involvement is highest with pulmonary malignancies. Although hypotheses implicating infectious, nutritional immunological, metabolic, and toxic factors have been suggested.1,3-7 the precise biological basis of these remote effects has not been determined. We provide here a clinical and anatomical report of a man who presented with dementia, developed inappropriate secretion of the antidiuretic hormone (ADH), and died six months later in status epilepticus. General autopsy revealed a bronchogenic carcinoma which had not References 1. Brain, W.R., and Norris, F.: The Remote Effects of Cancer on the Nervous System , New York: Grune & Stratton, Inc., 1965. 2. Croft, P.B., and Wilkinson, M.: The Incidence of Carcinomatous Neuromyopathy in Patients With Various Types of Carcinoma , Brain 88:427-434 ( (Sept) ) 1965.Crossref 3. Denny-Brown, D.: Primary Sensory Neuropathy With Muscular Changes Associated With Carcinoma , J Neurol Neurosurg Psychiat 11:73-87 ( (May) ) 1948.Crossref 4. Meyer, A.: " Nutritional Deficiencies and Disorders ," in Blackwood, W., et al (eds.): Greenfield's Neuropathology , Baltimore: Williams & Wilkins Co., 1963, pp 288-323. 5. Croft, P.B., et al: Sensory Neuropathy With Bronchial Carcinoma: A Study of Four Cases Showing Serological Abnormalities , Brain 88:501-514 ( (Sept) ) 1965.Crossref 6. Dayan, A.D.; Croft, P.B.; and Wilkinson, M.: Association of Carcinomatous Neuropathy With Different Histological Types of Carcinoma of the Lung , Brain 88:435-448 ( (Sept) ) 1965.Crossref 7. Zurhein, G.M.: Polyoma Like Virus in a Human Demyelinating Disease , Acta Neuropath 8:57-68 ( (March) ) 1967.Crossref 8. Sethurajan, C.; Croft, P.B.; and Wilkinson, M.: Bronchial Neoplasm With Endocrine, Metabolic and Neurological Manifestations , Neurology 17:1169-1173 ( (Dec) ) 1967.Crossref 9. Kennedy, W.R., and Jimenez-Pabon, E.: The Myasthenic Syndrome Associated With Small Cell Carcinoma of the Lung , Neurology 18:757-766 ( (Aug) ) 1968.Crossref 10. Hirano, A., and Zimmerman, H.M.: Silver Impregnation of Nerve Cells and Fibers in Celloidin Sections , Arch Neurol 6:114-122 ( (Feb) ) 1962.Crossref 11. Crosby, E.C.; Humphrey, T.; and Lauer, E.W.: Correlative Anatomy of the Nervous System : New York: Macmillan Co., 1962, pp 266-342, 388, 497. 12. Brain, R., and Henson, R.A.: Neurological Syndromes Associated With Carcinoma: The Carcinomatous Neuromyopathies , Lancet 2:971-974 ( (Nov 8) ) 1958.Crossref 13. Henson, R.A.; Hoffman, H.L.; and Urich, H.: Encephalomyelitis With Carcinoma , Brain 88:449-464 ( (Sept) ) 1965.Crossref 14. Brain, R., and Wilkinson, M.: Subacute Cerebellar Degeneration Associated With Neoplasms , Brain 88:465-478 ( (Sept) ) 1965.Crossref 15. Charatan, F.B., and Brierley, J.B.: Mental Disorder Associated With Primary Lung Carcinoma , Brit Med J 1:765-768 ( (April 7) ) 1956.Crossref 16. McGovern, G.P.; Miller, D.H.; and Robertson, E.E.: A Mental Syndrome Associated With Lung Carcinoma , Arch Neurol Psychiat 81:341-347 ( (March) ) 1959.Crossref 17. Hutchinson, E.C., et al: Neurological Complications of the Reticuloses , Brain 81:75-92 ( (March) ) 1958.Crossref 18. Yahr, M.D.; Duvoisin, R.C.; and Cowen, D.: Encephalopathy Associated With Carcinoma , Trans Amer Neurol Assoc 90:80-86, 1965. 19. Nelson, J.S.; Woolsey, R.M.; and Broun, G.O.: Cortical Degeneration Associated With Myeloma and Dementia , J Neuropath Exp Neurol 25:489-497 ( (July) ) 1966.Crossref 20. Ulrich, J.; Spiess, H.; and Huber, R.: Neurologische Syndrome als Fernwirkung Maligner Tumoren (Ammonshornsklerose bei Bronchuskarzinom) , Schweiz Arch Neurol Neurochir Psychiat 99:83-100, 1967. 21. Corsellis, J.A.N.; Goldberg, G.J.; and Norton, A.R.: "Limbic Encephalitis" and Its Association With Carcinoma , Brain 91:481-496 ( (Sept) ) 1968.Crossref 22. Bickerstaff, E.R.; Elabute, E.A.; and Woolf, A.L.: Severe Cerebral Degeneration Associated With Primary Hepatic Carcinoma , J Neurol Neurosurg Psychiat 29:556-559 ( (Dec) ) 1966.Crossref 23. Richardson, E.P.: " Progressive Multifocal Leukoencephalopathy ," in Brain, W.R., and Norris, F. (eds.): The Remote Effects of Cancer on the Nervous System , New York: Grune & Stratton, Inc., 1965, pp 6-16. 24. Victor, M.: " The Effects of Nutritional Deficiency on the Nervous System: A Comparison With the Effects of Carcinoma ," in Brain, W.R., and Norris, F. (eds.): The Remote Effects of Cancer on the Nervous System , New York: Grune & Stratton, Inc., 1965, pp 134-161. 25. Stern, K.: Severe Dementia Associated With Bilateral Symmetrical Degeneration of the Thalamus , Brain 62:157-171 ( (June) ) 1939.Crossref 26. Grunthal, E.: Uber Thalamische Demenz , Mschr Psychiat Neurol 106:114-128 ( (Aug-Oct) ) 1942.Crossref 27. Schulman, S.: Bilateral Symmetrical Degeneration of the Thalamus: A Clinico-Pathological Study , J Neuropath Exp Neurol 16:446-470 ( (Oct) ) 1957.Crossref 28. Martin, J.J.: Troubles psychiques dans une atrophie primitive des noyaux thalamiques dorsomedians , Rev Neurol 114:215-219 ( (March) ) 1966. 29. Castaigne, P., et al: Demence thalamique d'origine vasculaire par ramollissement bilateral, limite au territoire de pedicle retro mamillaire: A propos de deux observatious anatomo-cliniques , Rev Neurol 114:89-107 ( (Feb) ) 1966. 30. Barraquer-Bordas, L., et al: Sur une necorse thalamique avec meningoependymite subaigue contribution a l'etude des troubles psychiques d'origine mesencephalothalmique , Acta Neurol Belg 67:7-24 ( (Jan) ) 1967. 31. Cheek, W.R., and Taveras, J.M.: Thalamic Tumors , J Neurosurg 24:505-513 ( (Feb) ) 1966.Crossref 32. Garcin, R.; Brion, S.; and Khochnevis, A.A.: Le syndrome de creutzfeldt-Jakob et les syndromes cortico-stries du presenium (a l'occasion de 5 observations anatomo-cliniques) , Rev Neurol 109:419-441 ( (No. 4) ) 1963. 33. McMenemey, W.H.; Grant, H.C.; and Behrman, S.: Two Examples of "Pre-senile Dementia" (Pick's Disease and Stern-Garcin Syndrome), With a History of Trauma , Arch Psychiat Nervenkr 207:128-140 ( (Sept) ) 1965. 34. Martin, J.J.: Sur une degenerescence systematise de centre median , J Hirnforsch 9:345-357 ( (No. 4) ) 1967. 35. Kirschbaum, W.R.: Jakob-Creutzfeldt Disease , New York: American Elsevier Publishing Co., 1968. 36. Vanderwolf, C.H.: Recovery From Large Medial Thalamic Lesions as a Result of Electroconvulsive Therapy , J Neurol Neurosurg Psychiat 31:67-72 ( (Feb) ) 1968.Crossref 37. Wells, J.: The Pathway From the Dorsomedial Thalamus to the Frontal Lobe , Exp Neurol 14:338-350 ( (March) ) 1966.Crossref 38. McLardy, T.: Thalamic Projection to the Frontal Cortex in Man , J Neurol Neurosurg Psychiat 13:198-202 ( (Aug) ) 1950.Crossref 39. Yokoi, S.: Neuropathological Study of Prefrontal Lobotomy , J Neuropath Exp Neurol 16:251-260 ( (April) ) 1957.Crossref 40. Locke, S.: Thalamic Connections to Insular and Opercular Cortex of Monkey , J Comp Neurol 129:219-240 ( (March) ) 1967.Crossref 41. Carman, J.B.; Cowan, W.M.; and Powell, P.S.: The Cortical Projection Upon the Claustrum , J Neurol Neurosurg Psychiat 27:46-51 ( (Feb) ) 1964.Crossref 42. May, W.W.: Creutzfeldt-Jakob Disease . Acta Neurol Scand 44( (pt 1) ):1-32, 1968.Crossref 43. Martin, J.J.: Topographie et signification des lesions thalamiques dans la maladie Creutzfeldt-Jakob et les formes apparentees , J Hirnforsch 8:137-160 ( (No. 2) ) 1966. 44. Bartter, F.C., and Schwartz, W.B.: The Syndrome of Inappropriate Secretion of Anti-diuretic Hormone , Amer J Med 42:790-806 ( (May) ) 1967.Crossref 45. Schwartz, W.B., et al: A Syndrome of Renal Sodium Loss and Hyponatremia Probably Resulting From Inappropriate Secretion of Anti-diuretic Hormone , Amer J Med 23:529-542 ( (Oct) ) 1957.Crossref 46. Vorherr, H., et al: Anti-diuretic Principle in Malignant Tumor Extracts from Patients With Inappropriate ADH Syndrome , J Clin Endocr 28:162-168 ( (Feb) ) 1968.Crossref 47. Hayward, J.N., and Smith, W.K.: Influence of Limbic System on Neurohypophysis , Arch Neurol 9:171-177 ( (Aug) ) 1963.Crossref 48. Rovit, R.L., and Sigler, M.H.: Hyponatremia With Herpes Simplex Encephalitis , Arch Neurol 10:595-603 ( (June) ) 1964.Crossref 49. Dingman, J.F., et al: Abnormal N-ural Regulation of Vasopressin and Aldosterone Secretion in a Patient With Cerebral Hyponatremia , J Clin Invest 41:1354 ( (June) ) 1962. 50. Cort, J.H.: Cerebral Salt Wasting , Lancet 1:752-754 ( (April 10) ) 1954.Crossref 51. Wise, B.L.: Inappropriate Secretion of ADH Caused by Obstruction of Ventriculoatrial Shunts , J Neurosurg 28:429-433 ( (May) ) 1968.Crossref 52. Ludwig, G.D., and Goldberg, M.: Hvponatremia in Acute Intermittent Porphyria Probably Resulting From Inappropriate Secretion of Antidiuretic Hormone , Ann NY Acad Sci 104:710-734 ( (March) ) 1963.Crossref 53. Posner, J.B., et al: Hyponatremia in Acute Polyneuropathy , Arch Neurol 17:530-541 ( (Nov) ) 1967.Crossref 54. Dosseter, J.B.; Venning, E.H.; and Beck, J.C.: Hyponatremia Associated with Superior Vena Cava Obstruction , Metabolism 10:149-161 ( (Feb) ) 1961. 55. Wynn, V.: Water Intoxication and Serum Hypotonicity , Metabolism 5:490-499 ( (July) ) 1956. 56. Gastaut, H.; Naquet, R.; and Fischer-Williams, M.: The Pathophysiology of Grand Mal Seizures Generalized From the Start , J Nerv Ment Dis 127:21-33 ( (July) ) 1958.Crossref 57. Williams, D.: The Thalamus and Epilepsy , Brain 88:539-556 ( (Sept) ) 1965.Crossref 58. Mullan, S., et al: Thalamic Lesions for the Control of Epilepsy , Arch Neurol 16:277-285 ( (March) ) 1967.Crossref 59. Kaada, B.R.: " Cingulate, Posterior, Orbital, Anterior Insular and Temporal Pole Cortex ," in Field, J. (ed.): Handbook of Physiology: Section I. Neurophysiology , Washington, DC: American Physiological Society, 1960, vol 2, pp 1345-1372.
Archives of Neurology – American Medical Association
Published: Jul 1, 1969
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