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Histochemical and Contractile Properties in the Cross-Innervated Guinea Pig Soleus Muscle

Histochemical and Contractile Properties in the Cross-Innervated Guinea Pig Soleus Muscle Abstract THE soleus muscle of the adult guinea pig is well suited for a quantitative investigation of both histochemical and physiological consequences of cross-innervation: (1) Histochemically, it contains only type I extrafusal muscle fibers, as determined with the myofibrillar adenosine triphosphatase (ATPase) reaction, whereas in all other species studied (cat, rat, mouse, rabbit, or dog) it contains a variable number of type II fibers.1 (Histochemical type I fibers contain high activity of most oxidative enzymes and low activity of myofibrillar ATPase and amylophosphorylase; type II fibers have opposite relative activities.) (2) Physiologically it is a typical "slow" twitch muscle. (3) It is possible to reinnervate the denervated soleus by nerves which normally innervate histochemically "mixed" and physiologically "fast" muscles, after which a variable number of type II muscle fibers appear.2 We have studied both the degree of "speeding" and the relative proportion of type II fibers after cross-innervation.3 References 1. Karpati, G., and Engel, W.K.: Neuronal Trophic Function , Arch Neurol 17:542-545 ( (Nov) ) 1967.Crossref 2. Karpati, G., and Engel, W.K.: Transformation of the Histochemical Profile of Skeletal Muscle by "Foreign" Innervation , Nature 215:1509-1510 ( (Sept) ) 1967.Crossref 3. Romanul, F.C.A., and Van der Meulen, F.P.: Slow and Fast Muscles After Cross-Innervation , Arch Neurol 17:387-402 ( (Oct) ) 1967.Crossref 4. Engel, W.K., and Brook, M.H.: " Muscle Biopsy as a Clinical Diagnostic Aid ," in Fields, W.S. (ed.): Neurological Diagnostic Techniques , Springfield, Ill: Charles C Thomas Publishers, 1966. 5. Karpati, G., and Engel, W.K.: Histochemical Investigation of Fiber Type Ratios With the Myofibrillar ATPase Reaction in Normal and Denervated Skeletal Muscles of Guinea Pig , Amer J Anat 122:145-155 ( (Jan) ) 1968.Crossref 6. Engel, W.K.: The Essentiality of Histo- and Cytochemical Studies of Skeletal Muscle in the Investigation of Neuromuscular Disease , Neurology 12:778-794 ( (Nov) ) 1962.Crossref 7. Buller, A.J., and Lewis, D.M.: "Factors Affecting the Differentiation of Mammalian Fast and Slow Muscle Fibers," in Gutmann, E., and Hnik, P. (eds.): in the Proceedings of Symposium on the Effect of Use and Disuse on Neuromuscular Functions, Prague: Czechoslovak Academy of Science, 1963. 8. Close, R.: Properties of Motor Units in Fast and Slow Skeletal Muscles of the Rat , J Physiol 193:45-55 ( (Nov) ) 1967. 9. Macpherson, L., and Wilkie, D.R.: The Duration of the Active State in a Muscle Twitch , J Physiol 124:292-299 ( (May) ) 1954. 10. Buller, A.J., and Lewis, D.M.: The Rate of Tension Development in Isometric Tetanic Contractions of Mammalian Fast and Slow Skeletal Muscle , J Physiol 176:337-354 ( (Feb) ) 1964. 11. Wells, J.B.: Comparison of Mechanical Properties Between Fast and Slow Mammalian Muscles , J Physiol 178:252-269 ( (May) ) 1965. 12. Biscoe, T.J., and Taylor, A.: The Effect of Admixture of Fast and Slow Muscle in Determining the Form of the Muscle Twitch , Med Biol Engineering 5:473-479 ( (Sept) ) 1967.Crossref 13. Burke, R.: Motor Unit Types of Cat Triceps Surae Muscle , J Physiol 193:141-160 ( (Nov) ) 1967. 14. McPhedran, A.M.; Wuerker, R.B.; and Henneman, E.: Properties of Motor Units in a Homogeneous Red Muscle (Soleus) of the Cat , J Neurophysiol 28:71-84 ( (Jan) ) 1965. 15. Close, R.: Dynamic Properties of Fast and Slow Skeletal Muscles of the Rat During Development , J Physiol 173:74-95 ( (Sept) ) 1964. 16. Close, R.: The Relation Between Intrinsic Speed of Shortening and Duration of the Active State of the Muscle , J Physiol 180:542-559 ( (Oct) ) 1965. 17. Hnik, P., et al: Fast and Slow Muscles of the Chick After Nerve Cross-Union , J Physiol 193:309-326 ( (Nov) ) 1967. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Histochemical and Contractile Properties in the Cross-Innervated Guinea Pig Soleus Muscle

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1969.00480090106015
Publisher site
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Abstract

Abstract THE soleus muscle of the adult guinea pig is well suited for a quantitative investigation of both histochemical and physiological consequences of cross-innervation: (1) Histochemically, it contains only type I extrafusal muscle fibers, as determined with the myofibrillar adenosine triphosphatase (ATPase) reaction, whereas in all other species studied (cat, rat, mouse, rabbit, or dog) it contains a variable number of type II fibers.1 (Histochemical type I fibers contain high activity of most oxidative enzymes and low activity of myofibrillar ATPase and amylophosphorylase; type II fibers have opposite relative activities.) (2) Physiologically it is a typical "slow" twitch muscle. (3) It is possible to reinnervate the denervated soleus by nerves which normally innervate histochemically "mixed" and physiologically "fast" muscles, after which a variable number of type II muscle fibers appear.2 We have studied both the degree of "speeding" and the relative proportion of type II fibers after cross-innervation.3 References 1. Karpati, G., and Engel, W.K.: Neuronal Trophic Function , Arch Neurol 17:542-545 ( (Nov) ) 1967.Crossref 2. Karpati, G., and Engel, W.K.: Transformation of the Histochemical Profile of Skeletal Muscle by "Foreign" Innervation , Nature 215:1509-1510 ( (Sept) ) 1967.Crossref 3. Romanul, F.C.A., and Van der Meulen, F.P.: Slow and Fast Muscles After Cross-Innervation , Arch Neurol 17:387-402 ( (Oct) ) 1967.Crossref 4. Engel, W.K., and Brook, M.H.: " Muscle Biopsy as a Clinical Diagnostic Aid ," in Fields, W.S. (ed.): Neurological Diagnostic Techniques , Springfield, Ill: Charles C Thomas Publishers, 1966. 5. Karpati, G., and Engel, W.K.: Histochemical Investigation of Fiber Type Ratios With the Myofibrillar ATPase Reaction in Normal and Denervated Skeletal Muscles of Guinea Pig , Amer J Anat 122:145-155 ( (Jan) ) 1968.Crossref 6. Engel, W.K.: The Essentiality of Histo- and Cytochemical Studies of Skeletal Muscle in the Investigation of Neuromuscular Disease , Neurology 12:778-794 ( (Nov) ) 1962.Crossref 7. Buller, A.J., and Lewis, D.M.: "Factors Affecting the Differentiation of Mammalian Fast and Slow Muscle Fibers," in Gutmann, E., and Hnik, P. (eds.): in the Proceedings of Symposium on the Effect of Use and Disuse on Neuromuscular Functions, Prague: Czechoslovak Academy of Science, 1963. 8. Close, R.: Properties of Motor Units in Fast and Slow Skeletal Muscles of the Rat , J Physiol 193:45-55 ( (Nov) ) 1967. 9. Macpherson, L., and Wilkie, D.R.: The Duration of the Active State in a Muscle Twitch , J Physiol 124:292-299 ( (May) ) 1954. 10. Buller, A.J., and Lewis, D.M.: The Rate of Tension Development in Isometric Tetanic Contractions of Mammalian Fast and Slow Skeletal Muscle , J Physiol 176:337-354 ( (Feb) ) 1964. 11. Wells, J.B.: Comparison of Mechanical Properties Between Fast and Slow Mammalian Muscles , J Physiol 178:252-269 ( (May) ) 1965. 12. Biscoe, T.J., and Taylor, A.: The Effect of Admixture of Fast and Slow Muscle in Determining the Form of the Muscle Twitch , Med Biol Engineering 5:473-479 ( (Sept) ) 1967.Crossref 13. Burke, R.: Motor Unit Types of Cat Triceps Surae Muscle , J Physiol 193:141-160 ( (Nov) ) 1967. 14. McPhedran, A.M.; Wuerker, R.B.; and Henneman, E.: Properties of Motor Units in a Homogeneous Red Muscle (Soleus) of the Cat , J Neurophysiol 28:71-84 ( (Jan) ) 1965. 15. Close, R.: Dynamic Properties of Fast and Slow Skeletal Muscles of the Rat During Development , J Physiol 173:74-95 ( (Sept) ) 1964. 16. Close, R.: The Relation Between Intrinsic Speed of Shortening and Duration of the Active State of the Muscle , J Physiol 180:542-559 ( (Oct) ) 1965. 17. Hnik, P., et al: Fast and Slow Muscles of the Chick After Nerve Cross-Union , J Physiol 193:309-326 ( (Nov) ) 1967.

Journal

Archives of Neurology – American Medical Association

Published: Mar 1, 1969

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