Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cerebral Hypoxic Damage in Fetus and Newborn: Basic Patterns and Their Clinical Significance

Cerebral Hypoxic Damage in Fetus and Newborn: Basic Patterns and Their Clinical Significance Abstract TWO BASIC forms of hypoxic brain damage make their appearance in the fetus and newborn. The lesions, located in the cerebrum, distributed through the cortical and deep structures, are not of random occurrence. The cerebral damage evolves in precise patterns; the location of lesions is governed by the gestational age of the fetus or neonate at the time of the hypoxic event. This temporal factor is of significance not only in determining the anatomic pattern of the cerebral damage, but correspondingly, has a direct bearing on the ultimate form of the neurologic defect in infants who survive. Accordingly, the findings here offer an organic basis for correlating the occurrence of gestational complications, particularly prematurity, with the presence clinically of cerebral palsy, mental retardation, and other nervous system defects in infants who survive. Traditionally the occurrence of hypoxic damage in the neonatal brain has been minimized. References 1. Macgregor, A.R.: Pathology of Infancy and Childhood , Edinburgh and London: E. & S. Livingstone, Ltd., 1960, pp 28-54. 2. Towbin, A.: Cerebral Intraventricular Hemorrhage and Subependymal Matrix Infarction in the Fetus and Premature Newborn , Amer J Path 52:121-139 ( (Jan) ) 1968. 3. Banker, B.Q.: Cerebral Vascular Disease in Infancy and Childhood , J Neuropath Exp Neurol 20:127-140 ( (Jan) ) 1961.Crossref 4. Towbin, A.: " Massive Cerebral Hypoxic Damage in the Human Fetus Near Term ," in Proceedings of the Fifth International Congress of Neuropathologists , publication 100, Excerpta Medica International Congressional Series, 1965, pp 724-729. 5. Clifford, S.H.: The Effects of Asphyxia on the Newborn Infant , J Pediat 18:567-578 ( (May) ) 1941.Crossref 6. Potter, E.L.: Pathology of the Fetus and Infant , Chicago: Year Book Medical Publishers, Inc., 1961, 670 pp. 7. Gröntoft, O.: Intracerebral and Meningeal Hemorrhages in Perinatally Deceased Infants: Intracerebral Hemorrhages; Pathologic-Anatomical and Obstetrical Study , Acta Obstet Gynec Scand 3:308-334, 1953.Crossref 8. Cruickshank, J.N.: Child Life Investigations: The Causes of Neonatal Death , Privy Council, Medical Research Council , publication 145, Special Report Series, London: His Majesty's Stationery Office, 1930, pp 19-47. 9. Ross, J.J., and Dimmette, R.M.: Subependymal Cerebral Hemorrhages in Infancy , Amer J Dis Child 110:531-542 ( (Nov) ) 1965. 10. Schwartz, P.: Birth Injuries of the Newborn: Morphology, Pathogenesis, Clinical Pathology, and Prevention , New York: Hafner Publishing Co., Inc., 1961, pp 35-76. 11. Craig, W.S.: Intracranial Hemorrhage in the Newborn , Arch Dis Child 13:89-123 ( (June) ) 1938.Crossref 12. Larroche, J.C.: Hemorragies cerebrales intraventriculaires chez le premature , Biol Neonat 7:25-56 ( (Jan-Feb) ) 1964.Crossref 13. Macgregor, A.R.: The Pathology of Stillbirth and Neonatal Death , Brit Med Bull 4:174-178, 1946. 14. Holland, E.: " The Causation of Foetal Death ," in Reports on Public Health and Medical Subjects , publication 7, Ministry of Health, London: His Majesty's Stationery Office, 1922, pp 23-58. 15. Ylppö, A.: Pathologisch-anatomische Studien bei Frühgeborenen , Z Kinderheilk 20:212-431, 1919.Crossref 16. Scholz, W.: " Die nicht zur Erweichung führenden unvollstandigen Gewebsnekrosen (Elektive Parenchymnekrose) ," in Henke, F.; Lubarsch, O.; and Rössle, R. (eds.): Handbuch der speziellen pathologischen Anatomie und Histologie: Nervensystem , Berlin: Springer-Verlag, 1956, vol 13, pt 1, pp 1284-1325. 17. Malamud, N., et al: An Etiologic and Diagnostic Study of Cerebral Palsy , J Ped 65:270-293 ( (Aug) ) 1964.Crossref 18. Hallervorden, J.; and Meyer, J.E.: " Cerebrale Kinderlähmung ," in Henke, F.; Lubarsh, O.; and Rössle, R. (eds.): Handbuch der speziellen pathologischen Anatomie und Histologie: Nervensystem , Berlin: Springer-Verlag, 1956, vol 13, pt 4, pp 194-282. 19. Towbin, A.: The Pathology of Cerebral Palsy , Springfield, Ill: Charles C Thomas, Publisher, 1960. 20. Toverud, K.U.: Etiological Factors in Neonatal Mortality, With Special Reference to Cerebral Hemorrhage , Acta Paediat Scand 18:249-271, 1936.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Cerebral Hypoxic Damage in Fetus and Newborn: Basic Patterns and Their Clinical Significance

Towbin, Abraham
Archives of Neurology , Volume 20 (1) – Jan 1, 1969
Download PDF
9 pages

Loading next page...
 
/lp/american-medical-association/cerebral-hypoxic-damage-in-fetus-and-newborn-basic-patterns-and-their-nAjds3tomS

References (23)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1969.00480070045005
Publisher site
See Article on Publisher Site

Abstract

Abstract TWO BASIC forms of hypoxic brain damage make their appearance in the fetus and newborn. The lesions, located in the cerebrum, distributed through the cortical and deep structures, are not of random occurrence. The cerebral damage evolves in precise patterns; the location of lesions is governed by the gestational age of the fetus or neonate at the time of the hypoxic event. This temporal factor is of significance not only in determining the anatomic pattern of the cerebral damage, but correspondingly, has a direct bearing on the ultimate form of the neurologic defect in infants who survive. Accordingly, the findings here offer an organic basis for correlating the occurrence of gestational complications, particularly prematurity, with the presence clinically of cerebral palsy, mental retardation, and other nervous system defects in infants who survive. Traditionally the occurrence of hypoxic damage in the neonatal brain has been minimized. References 1. Macgregor, A.R.: Pathology of Infancy and Childhood , Edinburgh and London: E. & S. Livingstone, Ltd., 1960, pp 28-54. 2. Towbin, A.: Cerebral Intraventricular Hemorrhage and Subependymal Matrix Infarction in the Fetus and Premature Newborn , Amer J Path 52:121-139 ( (Jan) ) 1968. 3. Banker, B.Q.: Cerebral Vascular Disease in Infancy and Childhood , J Neuropath Exp Neurol 20:127-140 ( (Jan) ) 1961.Crossref 4. Towbin, A.: " Massive Cerebral Hypoxic Damage in the Human Fetus Near Term ," in Proceedings of the Fifth International Congress of Neuropathologists , publication 100, Excerpta Medica International Congressional Series, 1965, pp 724-729. 5. Clifford, S.H.: The Effects of Asphyxia on the Newborn Infant , J Pediat 18:567-578 ( (May) ) 1941.Crossref 6. Potter, E.L.: Pathology of the Fetus and Infant , Chicago: Year Book Medical Publishers, Inc., 1961, 670 pp. 7. Gröntoft, O.: Intracerebral and Meningeal Hemorrhages in Perinatally Deceased Infants: Intracerebral Hemorrhages; Pathologic-Anatomical and Obstetrical Study , Acta Obstet Gynec Scand 3:308-334, 1953.Crossref 8. Cruickshank, J.N.: Child Life Investigations: The Causes of Neonatal Death , Privy Council, Medical Research Council , publication 145, Special Report Series, London: His Majesty's Stationery Office, 1930, pp 19-47. 9. Ross, J.J., and Dimmette, R.M.: Subependymal Cerebral Hemorrhages in Infancy , Amer J Dis Child 110:531-542 ( (Nov) ) 1965. 10. Schwartz, P.: Birth Injuries of the Newborn: Morphology, Pathogenesis, Clinical Pathology, and Prevention , New York: Hafner Publishing Co., Inc., 1961, pp 35-76. 11. Craig, W.S.: Intracranial Hemorrhage in the Newborn , Arch Dis Child 13:89-123 ( (June) ) 1938.Crossref 12. Larroche, J.C.: Hemorragies cerebrales intraventriculaires chez le premature , Biol Neonat 7:25-56 ( (Jan-Feb) ) 1964.Crossref 13. Macgregor, A.R.: The Pathology of Stillbirth and Neonatal Death , Brit Med Bull 4:174-178, 1946. 14. Holland, E.: " The Causation of Foetal Death ," in Reports on Public Health and Medical Subjects , publication 7, Ministry of Health, London: His Majesty's Stationery Office, 1922, pp 23-58. 15. Ylppö, A.: Pathologisch-anatomische Studien bei Frühgeborenen , Z Kinderheilk 20:212-431, 1919.Crossref 16. Scholz, W.: " Die nicht zur Erweichung führenden unvollstandigen Gewebsnekrosen (Elektive Parenchymnekrose) ," in Henke, F.; Lubarsch, O.; and Rössle, R. (eds.): Handbuch der speziellen pathologischen Anatomie und Histologie: Nervensystem , Berlin: Springer-Verlag, 1956, vol 13, pt 1, pp 1284-1325. 17. Malamud, N., et al: An Etiologic and Diagnostic Study of Cerebral Palsy , J Ped 65:270-293 ( (Aug) ) 1964.Crossref 18. Hallervorden, J.; and Meyer, J.E.: " Cerebrale Kinderlähmung ," in Henke, F.; Lubarsh, O.; and Rössle, R. (eds.): Handbuch der speziellen pathologischen Anatomie und Histologie: Nervensystem , Berlin: Springer-Verlag, 1956, vol 13, pt 4, pp 194-282. 19. Towbin, A.: The Pathology of Cerebral Palsy , Springfield, Ill: Charles C Thomas, Publisher, 1960. 20. Toverud, K.U.: Etiological Factors in Neonatal Mortality, With Special Reference to Cerebral Hemorrhage , Acta Paediat Scand 18:249-271, 1936.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Jan 1, 1969

There are no references for this article.