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C.L. Markert (1963)
Lactate Dehydrogenase Isozymes: Dissociation and Recombination of UnitsScience, 14
B. Hill, C. Levi (1954)
Elevation of a serum component in neoplastic disease.Cancer research, 14 7
J. Kernohan, R. Mabon (1949)
A simplified classification of the gliomas.Proceedings of the staff meetings. Mayo Clinic, 24 3
V. Bonavita, F. Ponte, G. Amore (1962)
Lactate Dehydrogenase Isozymes in the Developing Rat BrainNature, 196
W. Gerhardt, J. Clausen, Erna Christensen, J. Rushede (1963)
CHANGES OF LDH‐ISOZYMES, ESTERASES, ACID PHOSPHATASES AND PROTEINS IN MALIGNANT AND BENIGN HUMAN BRAIN TUMORSActa Neurologica Scandinavica, 39
F. Corridori, T. Cremona, G. Tagliabue (1960)
GLUTAMIC‐OXALACETIC TRANSAMINASE AND LACTIC DEHYDROGENASE ACTIVITIES IN BRAIN TUMOUR HOMOGENATESJournal of Neurochemistry, 6
Irving Heller, K. Elliott (1955)
The metabolism of normal brain and human gliomas in relation to cell type and density.Canadian journal of biochemistry and physiology, 33 3
R. Richterich (1962)
Die differenzialdiagnose maligner und benigner Ergusse durch Bestimmung der Lactat dehydrogenase-IsoenzymeSchweiz Med Wschr, 92
O. Warburg (1956)
[Origin of cancer cells].Oncologia, 9 2
L. Cohen, J. Djordjevich, V. Ormiste (1964)
SERUM LACTIC DEHYDROGENASE ISOZYME PATTERNS IN CARDIOVASCULAR AND OTHER DISEASES, WITH PARTICULAR REFERENCE TO ACUTE MYOCARDIAL INFARCTION.The Journal of laboratory and clinical medicine, 64
O. Warburg (1956)
On the Origin of Cancer CellsScience, 123
P. Fritz (1965)
Rabbit Muscle Lactate Dehydrogenase 5; A Regulatory EnzymeScience, 150
R. Richterich, J. Locher, K. Zuppinger, E. Rossi (1962)
[The differential diagnosis of malignant and benign effusions by the determination of lactic dehydrogenase isoenzyme].Schweizerische medizinische Wochenschrift, 92
J. Clausen (1963)
Sequential Inhibition of Lactic Dehydrogenase Isozymes of Human Brain by Honvan (Stilboestrol Disphosphate)Acta Neurol Scand, 39
W. Gerhardt, J. Clausen, E. Christensen, J. Riishede (1967)
Lactate dehydrogenase isoenzymes in the diagnosis of human benign and malignant brain tumors.Journal of the National Cancer Institute, 38 3
W. Gerhardt, C. Petri (1965)
DISTRIBUTION OF LACTATE DEHYDROGENASE ISOZYMES OF HUMAN BRAIN TISSUEActa Neurologica Scandinavica, 41
R. Goldman, N. Kaplan, T. Hall (1964)
LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES.Cancer research, 24
J. Clausen, Willie Gerhardt (1963)
SEQUENTIAL INHIBITION OF LACTIC DEHYDROGENASE ISOZYMES OF HUMAN BRAIN BY HONVAN (STILBOESTROL DIPHOSPHATE) (In vitro experiments)Acta Neurologica Scandinavica, 39
M. Elhilali, J. Oliver, A. Sherwin, K. Mackinnon (1967)
Lactate dehydrogenase isoenzymes in hyperplasia and carcinoma of the prostate: a clinical study.The Journal of urology, 98 6
W. Starkweather, W. Starkweather, Green Ra, Green Ra, Spencer Hh, Spencer Hh, H. Schoch, H. Schoch (1966)
Alterations of serum lactate dehydrogenase isoenzymes during therapy directed at lung cancer.The Journal of laboratory and clinical medicine, 68 2
Otto Warburn, F. Dickens (1931)
THE METABOLISM OF TUMORSThe American Journal of the Medical Sciences, 182
Abstract NEOPLASMS have been shown to have different metabolic characteristics than normal tissues. Warburg1 observed a greater tendency to derive energy from anaerobic glycolysis with the production of increased amounts of lactic acid. He later suggested that an early step in the development of a neoplasm was a disturbance in cellular respiratory activity.2 Heller and Elliott showed that the rate of glycolysis was higher in human brain tumors than in normal gray matter when considered in relation to their respiratory rate.3 Hill and Levi4 noted that lactic dehydrogenase (LDH), the enzyme at the end of the metabolic chain of anaerobic glycolysis, was elevated in the serum of some patients with neoplastic disease. Increased amount of lactate and LDH have been found in brain tumor homogenates.5 In recent years it has been shown that the LDH activity of serum or tissue extracts is not References 1. Warburg, O.: The Metabolism of Tumors , F. Dickens (trans.), New York: Richard R. Smith Inc., 1931. 2. Warburg, O.: On the Origin of Cancer Cells , Science 123:309-314, 1956.Crossref 3. Heller, I.H., and Elliott, K.A.C.: The Metabolism of Normal Brain and Human Gliomas in Relation to Cell Type and Density , Canad J Biochem Physiol 33:395-403, 1955.Crossref 4. Hill, B.R., and Levi, C.: Elevation of a Serum Component in Neoplastic Disease , Cancer Res 14:513-515, 1954. 5. Corridori, F.; Cremona, T.; and Tagliabue, G.: Glutamic-Oxalacetic Transaminase and Lactic Dehydrogenase Activities in Brain Tumor Homogenate , J Neurochem 6:142-145, 1960.Crossref 6. Markert, C.L.: Lactate Dehydrogenase Isozymes: Dissociation and Recombination of Units , Science 14:1329-1330, 1963.Crossref 7. Gerhardt, W., et al: Changes of LDH-Isozymes, Esterases, and Acid Phosphatases and Proteins in Malignant and Benign Human Brain Tumors , Acta Neurol Scand 39:85-111, 1963.Crossref 8. Gerhardt, W., et al: Lactate Dehydrogenase Isozymes in the Diagnosis of Human Benign and Malignant Brain Tumors , J Nat Cancer Inst 38:343-356, 1967. 9. Kernohan, J.W., et al: A Simplified Classification of the Gliomas , Proc Mayo Clin 24:71-75, 1949. 10. Sano, K.; Chigasaki, H.; and Takakura, K.: "Diagnostic Value of LDH Isozyme Studies in Intracranial Tumor," in Fourth International Congress of Neurological Surgery, Copenhagen, Aug 27, 1965. 11. Cohen, L.; Djordjevich, J.; and Ormiste, V.: Serum Lactic Dehydrogenase Isozyme Patterns in Cardiovascular and Other Diseases, With Particular Reference to Acute Myocardial Infarction , J Lab Clin Med 64:355-374, 1964. 12. Fritz, P.: Rabbit Muscle Lactate Dehydrogenase 5: A Regulatory Enzyme , Science 150:364-366, 1965.Crossref 13. Goldman, R.D.; Kaplan, N.O.; and Hall, T.C.: Lactic Dehydrogenase in Human Neoplastic Tissues , Cancer Res 24:389-399, 1964. 14. Bonavita, V.; Ponte, F.; and Amore, G.: Lactate Dehydrogenase Isoenzymes in the Developing Rat Brain , Nature 196:576-577, 1962.Crossref 15. Gerhardt, W., and Petri, C.: Distribution of Lactate Dehydrogenase Isozymes of Human Brain Tissue , Acta Neurol Scand 41:609-621, 1964.Crossref 16. Richterich, R., et al: Die differenzialdiagnose maligner und benigner Ergusse durch Bestimmung der Lactat dehydrogenase-Isoenzyme , Schweiz Med Wschr 92:919-927, 1962. 17. Clausen, J., and Gerhardt, W.: Sequential Inhibition of Lactic Dehydrogenase Isozymes of Human Brain by Honvan (Stilboestrol Disphosphate) , Acta Neurol Scand 39:305-322, 1963.Crossref 18. Elhilali, M.M., et al: Lactate Dehydrogenase Isoenzymes in Hyperplasia and Carcinoma of the Prostate: A Clinical Study , J Urol , to be published. 19. Starkweather, W.H., et al: Alterations of Serum Lactate Dehydrogenase Isoenzymes During Therapy Directed at Lung Cancer , J Lab Clin Med 68:314-322, 1966.
Archives of Neurology – American Medical Association
Published: Mar 1, 1968
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