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Control Mechanisms in Cortical Epileptogenic Foci*: Surround Inhibition

Control Mechanisms in Cortical Epileptogenic Foci*: Surround Inhibition Abstract ELECTROPHYSIOLOGICAL investigations of cellular activities in cortical epileptogenic foci produced by strychnine,2,3 local freeze lesions,4,5 and penicillin application6-9 have revealed that the population of neurons in the area of focal surface epileptiform discharge is a heterogeneous one in terms of its behavior during surface paroxysmal discharges. (In order to avoid confusion in terminology, surface epileptiform discharge or surface paroxysmal discharge will be used throughout to refer to interictal focal epil-eptiform spikes. The term spike or unit spike will always refer to the neuronal action potential.) Intracellular records in such foci show that in most neurons excitatory events, ie, large depolarization shifts (DSs) and repetitive unit firing, accompany surface epileptiform activity; some neurons, however, are inhibited during the surface discharge.2,3,5,8,9 The role of inhibited neurons in a region of focal epileptogenesis and the relationship of such cells to the neuronal population responsible for generation of the surface References 1. Prince, D.A., and Wilder, B.J.: "Surround" Inhibition in Cortical Epileptogenic Foci , Trans Amer Neurol Assoc , to be published, 1967. 2. Li, C.L.: Cortical Intracellular Potentials and Their Responses to Strychnine , J Neurophysiol 22:436, 1959. 3. Li, C.L., and Chou, S.N.: " Inhibitory Interneurons in the Neocortex ," in Inhibitions of the Nervous System and Gamma-Aminobutyric Acid , London: Pergamon Press, 1960, pp 34-39. 4. Morrell, F.: Microelectrode Studies in Chronic Epileptic Foci , Epilepsia 2:81, 1961.Crossref 5. Goldensohn, E., and Purpura, D.P.: Intracellular Potentials of Cortical Neurons During Focal Epileptogenic Discharges , Science 193:840, 1963.Crossref 6. Matsumoto, H., and Ajmone Marsan, C.: Cortical Cellular Phenomena in Experimental Epilepsy: Ictal Manifestations , Exp Neurol 9:305, 1964.Crossref 7. Ajmone Marsan, C.: Unitary Analysis of "Projected" Epileptiform Dischages , Electroenceph Clin Neurophysiol 15:197, 1963.Crossref 8. Prince, D.A.: Modification of Cortical Epileptiform Discharge by Afferent Influences , Epilepsia 7:181, 1966.Crossref 9. Matsumoto, H., and Ajmone Marsan, C.: Cortical Cellular Phenomena in Experimental Epilepsy: Interictal Manifestations , Exp Neurol 9:286, 1964.Crossref 10. Jasper, H.H., and Ajmone Marsan, C.: A Stereotaxic Atlas of the Diencephalon of the Cat , Ottawa: National Research Council of Canada, 1954. 11. Prince, D.A., and Wilder, B.J.: Intracellular Events During "Triggered" Cortical Epileptiform Activity, Abstracts of American EEG Society , Electroenceph Clin Neurophysiol 21:400, 1966. 12. Hartline, H.K., and Ratliff, F.: Inhibitory Interaction of Receptor Units in the Eye of Limulus , J Gen Physiol 40:357, 1957.Crossref 13. Kuffler, S.W.: Discharge Patterns and Functional Organization of Mammalian Retina , J Neurophysiol 16:37, 1953. 14. Mountcastle, V.B.: Modality and Topographic Properties of Single Neurons of Cat's Somatic Sensory Cortex , J Neurophysiol 20:408, 1957. 15. Hubel, D.H., and Wiesel, T.N.: Receptive Fields of Single Neurones in the Cat's Striate Cortex , J Physiol 148:574, 1959. 16. Hubel, D.H., and Wiesel, T.N.: Receptive Fields, Binocular Interaction and Functional Architecture in the Cat's Visual Cortex , J Physiol 160:106, 1962. 17. Krnjević, K.; Randic, M.; and Straughan, D.W.: An Inhibitory Process in the Cerebral Cortex , J Physiol 184:16, 1966. 18. Krnjević, K.; Randic, M.; and Straughan, D.W.: Nature of a Cortical Inhibitory Process , J Physiol 184:49, 1966. 19. Phillips, C.G.: Actions of Antidromic Pyramidal Volleys on Single Betz Cells in the Cat , Quart J Exp Physiol 44:1, 1959. 20. Stefanis, C., and Jasper, H.: Recurrent Collateral Inhibition in Pyramidal Tract Neurons , J Neurophysiol 27:855, 1964. 21. Phillips, C.G.: Intracellular Records From Betz Cells in the Cat , Quart J Exp Physiol 41:58, 1956. 22. Eccles, J.C.: The Physiology of Synapses , New York: Academic Press, 1964, p 209. 23. Eccles, J.C., et al: Electrophysiological Investigations of Renshaw Cells , J Physiol 159:461, 1961. 24. Gumnit, R.J., and Takahashi, T.: Changes in Direct Current Activity During Experimental Focal Seizures , Electroenceph Clin Neurophysiol 19:63, 1965.Crossref 25. Klee, M.R.: Different Effects on the Membrane Potential of Motor Cortex Units After Thalamic and Reticular Stimulation , in The Thalamus , New York: Columbia University Press, 1966, pp 287-322. 26. Sawa, M.; Maruyama, N.; and Kaji, S.: Intracellular Potential During Electrically Induced Seizures , Electroenceph Clin Neurophysiol 15:209, 1963.Crossref 27. Purpura, D.P.; Shofer, R.J.; and Musgrave, F.S.: Cortical Intracellular Potentials During Augmenting and Recruiting Responses: II. Patterns of Synaptic Activities in Pyramidal and Nonpyramidal Tract Neurons , J Neurophysiol 27:133, 1964. 28. Køjewnikow: Eine besondere Form von corticaler Epilepsie , Neurol Centralbl 14:47, 1895. 29. Prince, D.A., and Wilder, B.J.: Control Mechanisms in Focal Epileptiform Discharge, Abstracts Western EEG Society , Electroenceph Clin Neurophysiol , to be published, 1967. 30. Penfield, W.: Ablation of Abnormal Cortex in Cerebral Palsy , J Neurol Neurosurg Psychiat 15:73, 1952.Crossref 31. Morrell, F.: Interseizure Disturbances in Focal Epilepsy , Neurology 6:327, 1956.Crossref 32. Morrell, F.; Roberts, L.; and Jasper, H.H.: Effect of Focal Epileptogenic Lesions and Their Ablation Upon Conditioned Electrical Responses of the Brain in the Monkey , Electroenceph Clin Neurophysiol 8:217, 1956.Crossref 33. Seino, M., and Wada, J.A.: Chronic Focal Cortical Epileptogenic Lesion and Behavior: Comparison of Behavioral Performance in Monkeys With Either Epileptogenic or Ablative Unilateral Lesion , Epilepsia 5:321, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Control Mechanisms in Cortical Epileptogenic Foci*: Surround Inhibition

Archives of Neurology , Volume 16 (2) – Feb 1, 1967

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References (32)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1967.00470200082007
Publisher site
See Article on Publisher Site

Abstract

Abstract ELECTROPHYSIOLOGICAL investigations of cellular activities in cortical epileptogenic foci produced by strychnine,2,3 local freeze lesions,4,5 and penicillin application6-9 have revealed that the population of neurons in the area of focal surface epileptiform discharge is a heterogeneous one in terms of its behavior during surface paroxysmal discharges. (In order to avoid confusion in terminology, surface epileptiform discharge or surface paroxysmal discharge will be used throughout to refer to interictal focal epil-eptiform spikes. The term spike or unit spike will always refer to the neuronal action potential.) Intracellular records in such foci show that in most neurons excitatory events, ie, large depolarization shifts (DSs) and repetitive unit firing, accompany surface epileptiform activity; some neurons, however, are inhibited during the surface discharge.2,3,5,8,9 The role of inhibited neurons in a region of focal epileptogenesis and the relationship of such cells to the neuronal population responsible for generation of the surface References 1. Prince, D.A., and Wilder, B.J.: "Surround" Inhibition in Cortical Epileptogenic Foci , Trans Amer Neurol Assoc , to be published, 1967. 2. Li, C.L.: Cortical Intracellular Potentials and Their Responses to Strychnine , J Neurophysiol 22:436, 1959. 3. Li, C.L., and Chou, S.N.: " Inhibitory Interneurons in the Neocortex ," in Inhibitions of the Nervous System and Gamma-Aminobutyric Acid , London: Pergamon Press, 1960, pp 34-39. 4. Morrell, F.: Microelectrode Studies in Chronic Epileptic Foci , Epilepsia 2:81, 1961.Crossref 5. Goldensohn, E., and Purpura, D.P.: Intracellular Potentials of Cortical Neurons During Focal Epileptogenic Discharges , Science 193:840, 1963.Crossref 6. Matsumoto, H., and Ajmone Marsan, C.: Cortical Cellular Phenomena in Experimental Epilepsy: Ictal Manifestations , Exp Neurol 9:305, 1964.Crossref 7. Ajmone Marsan, C.: Unitary Analysis of "Projected" Epileptiform Dischages , Electroenceph Clin Neurophysiol 15:197, 1963.Crossref 8. Prince, D.A.: Modification of Cortical Epileptiform Discharge by Afferent Influences , Epilepsia 7:181, 1966.Crossref 9. Matsumoto, H., and Ajmone Marsan, C.: Cortical Cellular Phenomena in Experimental Epilepsy: Interictal Manifestations , Exp Neurol 9:286, 1964.Crossref 10. Jasper, H.H., and Ajmone Marsan, C.: A Stereotaxic Atlas of the Diencephalon of the Cat , Ottawa: National Research Council of Canada, 1954. 11. Prince, D.A., and Wilder, B.J.: Intracellular Events During "Triggered" Cortical Epileptiform Activity, Abstracts of American EEG Society , Electroenceph Clin Neurophysiol 21:400, 1966. 12. Hartline, H.K., and Ratliff, F.: Inhibitory Interaction of Receptor Units in the Eye of Limulus , J Gen Physiol 40:357, 1957.Crossref 13. Kuffler, S.W.: Discharge Patterns and Functional Organization of Mammalian Retina , J Neurophysiol 16:37, 1953. 14. Mountcastle, V.B.: Modality and Topographic Properties of Single Neurons of Cat's Somatic Sensory Cortex , J Neurophysiol 20:408, 1957. 15. Hubel, D.H., and Wiesel, T.N.: Receptive Fields of Single Neurones in the Cat's Striate Cortex , J Physiol 148:574, 1959. 16. Hubel, D.H., and Wiesel, T.N.: Receptive Fields, Binocular Interaction and Functional Architecture in the Cat's Visual Cortex , J Physiol 160:106, 1962. 17. Krnjević, K.; Randic, M.; and Straughan, D.W.: An Inhibitory Process in the Cerebral Cortex , J Physiol 184:16, 1966. 18. Krnjević, K.; Randic, M.; and Straughan, D.W.: Nature of a Cortical Inhibitory Process , J Physiol 184:49, 1966. 19. Phillips, C.G.: Actions of Antidromic Pyramidal Volleys on Single Betz Cells in the Cat , Quart J Exp Physiol 44:1, 1959. 20. Stefanis, C., and Jasper, H.: Recurrent Collateral Inhibition in Pyramidal Tract Neurons , J Neurophysiol 27:855, 1964. 21. Phillips, C.G.: Intracellular Records From Betz Cells in the Cat , Quart J Exp Physiol 41:58, 1956. 22. Eccles, J.C.: The Physiology of Synapses , New York: Academic Press, 1964, p 209. 23. Eccles, J.C., et al: Electrophysiological Investigations of Renshaw Cells , J Physiol 159:461, 1961. 24. Gumnit, R.J., and Takahashi, T.: Changes in Direct Current Activity During Experimental Focal Seizures , Electroenceph Clin Neurophysiol 19:63, 1965.Crossref 25. Klee, M.R.: Different Effects on the Membrane Potential of Motor Cortex Units After Thalamic and Reticular Stimulation , in The Thalamus , New York: Columbia University Press, 1966, pp 287-322. 26. Sawa, M.; Maruyama, N.; and Kaji, S.: Intracellular Potential During Electrically Induced Seizures , Electroenceph Clin Neurophysiol 15:209, 1963.Crossref 27. Purpura, D.P.; Shofer, R.J.; and Musgrave, F.S.: Cortical Intracellular Potentials During Augmenting and Recruiting Responses: II. Patterns of Synaptic Activities in Pyramidal and Nonpyramidal Tract Neurons , J Neurophysiol 27:133, 1964. 28. Køjewnikow: Eine besondere Form von corticaler Epilepsie , Neurol Centralbl 14:47, 1895. 29. Prince, D.A., and Wilder, B.J.: Control Mechanisms in Focal Epileptiform Discharge, Abstracts Western EEG Society , Electroenceph Clin Neurophysiol , to be published, 1967. 30. Penfield, W.: Ablation of Abnormal Cortex in Cerebral Palsy , J Neurol Neurosurg Psychiat 15:73, 1952.Crossref 31. Morrell, F.: Interseizure Disturbances in Focal Epilepsy , Neurology 6:327, 1956.Crossref 32. Morrell, F.; Roberts, L.; and Jasper, H.H.: Effect of Focal Epileptogenic Lesions and Their Ablation Upon Conditioned Electrical Responses of the Brain in the Monkey , Electroenceph Clin Neurophysiol 8:217, 1956.Crossref 33. Seino, M., and Wada, J.A.: Chronic Focal Cortical Epileptogenic Lesion and Behavior: Comparison of Behavioral Performance in Monkeys With Either Epileptogenic or Ablative Unilateral Lesion , Epilepsia 5:321, 1964.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Feb 1, 1967

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