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Peripheral Nerve Damage by Cold

Peripheral Nerve Damage by Cold Abstract WE HAVE studied the histological and clinical effects of low temperatures on the sciatic nerve of the cat. A selective effect on small nerve fibers by chemicophysical means has been previously reported by several workers.1,2 The possibility that cold might selectively destroy large nerve fibers was suggested by the pathological study of colddamaged nerve by Denny-Brown et al.3 In addition, physiological studies during cooling of peripheral nerve by Douglas and Malcolm4 showed selective blockage of small fibers. Interest in nerve damage by cold received considerable stimulus during the 1940's as a result of exposure injuries consequent to the war. Blackwood5 reported findings in 14 cases of immersion foot, mostly in sailors exposed in open boats. He found that immersion for short duration produced less degeneration of axons and myelin than did more prolonged exposures. Blackwood and Russell6 produced degeneration in rat nerves by immersing References 1. Matthews, P.B.C., and Rushworth, G.: The Selective Effect of Procaine on the Stretch Reflex and Tendon Jerk of Soleus Muscle When Applied to Its Nerve , J Physiol 135:245-262, 1957. 2. Nathan, P.W., and Sears, T.A.: The Susceptibility of Nerve Fibers to Analgesics , Anaesthesia 18:467-476, 1963.Crossref 3. Denny-Brown, D., et al: The Pathology of Injury to Nerve Induced by Cold , J Neuropath Exp Neurol 4:305-323, 1945.Crossref 4. Douglas, W.W., and Malcolm, J.L.: The Effect of Localized Cooling on Conduction in Cat Nerves , J Physiol 130:53-71, 1955. 5. Blackwood, W.: Discussion on Immersion Injuries , Proc Roy Soc Med 36:521, 1943. 6. Blackwood, W., and Russell, H.: Experiments on the Study of Immersion Foot , Edinburgh Med J 50:385, 1943. 7. Miyazaki, Y., et al: Localized Cooling in the Central Nervous System: II. Histological Results , Arch Neurol Psychiat 9:392-399, 1963.Crossref 8. Paintal, A.S.: Block of Conduction in Mammalian Myelinated Nerve Fibers by Low Temperature , J Physiol 180:1-19, 1965. 9. Byck, R., et al: Reversible Differential Block of Saphenous Nerve by Cold, Proceedings of International Congress of Biophysics, Vienna, September 1966, Vienna: Abstracts of the Second International Biophysics Congress, 1966. 10. Miller, L.K.: Activity in Mammalian Peripheral Nerves During Supercooling , Science 149:74-75, 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1967.00470190107013
Publisher site
See Article on Publisher Site

Abstract

Abstract WE HAVE studied the histological and clinical effects of low temperatures on the sciatic nerve of the cat. A selective effect on small nerve fibers by chemicophysical means has been previously reported by several workers.1,2 The possibility that cold might selectively destroy large nerve fibers was suggested by the pathological study of colddamaged nerve by Denny-Brown et al.3 In addition, physiological studies during cooling of peripheral nerve by Douglas and Malcolm4 showed selective blockage of small fibers. Interest in nerve damage by cold received considerable stimulus during the 1940's as a result of exposure injuries consequent to the war. Blackwood5 reported findings in 14 cases of immersion foot, mostly in sailors exposed in open boats. He found that immersion for short duration produced less degeneration of axons and myelin than did more prolonged exposures. Blackwood and Russell6 produced degeneration in rat nerves by immersing References 1. Matthews, P.B.C., and Rushworth, G.: The Selective Effect of Procaine on the Stretch Reflex and Tendon Jerk of Soleus Muscle When Applied to Its Nerve , J Physiol 135:245-262, 1957. 2. Nathan, P.W., and Sears, T.A.: The Susceptibility of Nerve Fibers to Analgesics , Anaesthesia 18:467-476, 1963.Crossref 3. Denny-Brown, D., et al: The Pathology of Injury to Nerve Induced by Cold , J Neuropath Exp Neurol 4:305-323, 1945.Crossref 4. Douglas, W.W., and Malcolm, J.L.: The Effect of Localized Cooling on Conduction in Cat Nerves , J Physiol 130:53-71, 1955. 5. Blackwood, W.: Discussion on Immersion Injuries , Proc Roy Soc Med 36:521, 1943. 6. Blackwood, W., and Russell, H.: Experiments on the Study of Immersion Foot , Edinburgh Med J 50:385, 1943. 7. Miyazaki, Y., et al: Localized Cooling in the Central Nervous System: II. Histological Results , Arch Neurol Psychiat 9:392-399, 1963.Crossref 8. Paintal, A.S.: Block of Conduction in Mammalian Myelinated Nerve Fibers by Low Temperature , J Physiol 180:1-19, 1965. 9. Byck, R., et al: Reversible Differential Block of Saphenous Nerve by Cold, Proceedings of International Congress of Biophysics, Vienna, September 1966, Vienna: Abstracts of the Second International Biophysics Congress, 1966. 10. Miller, L.K.: Activity in Mammalian Peripheral Nerves During Supercooling , Science 149:74-75, 1965.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Jan 1, 1967

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