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Decerebrate Phenomena After Carotid Amobarbital Injection

Decerebrate Phenomena After Carotid Amobarbital Injection Abstract Introduction The recent use of intracarotid amobarbital (Amytal) injection for determination of hemisphere dominance and site of epileptogenic focus demonstrated that the infusion causes a transient impairment in cerebral function.1-4 The brief loss of function can be associated with corresponding loss of motor activity, and this in turn can in some patients lead to release of subcortical postural mechanisms. This provides a means of comparing residual lower level integration in patients having hemiplegias of vascular or traumatic origin with that of patients manifesting extrapyramidal disorders of motor function. We sought to ascertain whether such paralysis and release symptoms could aid further understanding of the nature of spasticity and dystonia, or provide an objective measure of the activity of subcortical motor mechanisms.The group of patients tested consisted of six hemiplegics, six patients with Parkinson's disease, four patients with Huntington's chorea, one case of double athetosis, and one patient with References 1. Wada, J.: A New Method for the Determination of the Side of Cerebral Speech Dominance: A Preliminary Report on the Intracarotid Injection of Sodium Amytal in Man , Med Biol (Tokyo) 14:221222, 1949. 2. Wada, J., and Rasmussen, T.: Intracarotid Injection of Sodium Amytal for the Lateralization of Cerebral Speech Dominance , J Neurosurg 17:226-282, 1960.Crossref 3. Perria, L.; Rosadini, G.; and Rossi, G. F.: Determination of Side of Cerebral Dominance with Amobarbital , Arch Neurol 4:173-181, 1961.Crossref 4. Rovit, R. L.; Gloor, P.; and Rasmussen, T.: Intracarotid Amobarbital in Epileptic Patients , Arch Neurol 5:606-626, 1961.Crossref 5. Werman, R.; Christoff, N.; and Anderson, P. J.: Neurological Changes with Intracarotid Amytal and Megimide in Man , J Neurol Neurosurg Psychiat 22:333-337, 1959.Crossref 6. Obrador, S.; Carrascosa, R.; and Carbonell, J.: Study of Some Motor Syndromes (Rigidity, Tremor, Spasticity and Hemidecortication) by the Carotid Amytal Test , J Neurosurg 18:507-511, 1961.Crossref 7. Kjellberg, R. N.: Discussion in Werman, R.; Christoff, N.; and Anderson, P. J.: Behavioral and EEG Changes Induced by Intracarotid Drugs , Trans Amer Neurol Ass 74-76, 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Decerebrate Phenomena After Carotid Amobarbital Injection

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1963.00460060092009
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction The recent use of intracarotid amobarbital (Amytal) injection for determination of hemisphere dominance and site of epileptogenic focus demonstrated that the infusion causes a transient impairment in cerebral function.1-4 The brief loss of function can be associated with corresponding loss of motor activity, and this in turn can in some patients lead to release of subcortical postural mechanisms. This provides a means of comparing residual lower level integration in patients having hemiplegias of vascular or traumatic origin with that of patients manifesting extrapyramidal disorders of motor function. We sought to ascertain whether such paralysis and release symptoms could aid further understanding of the nature of spasticity and dystonia, or provide an objective measure of the activity of subcortical motor mechanisms.The group of patients tested consisted of six hemiplegics, six patients with Parkinson's disease, four patients with Huntington's chorea, one case of double athetosis, and one patient with References 1. Wada, J.: A New Method for the Determination of the Side of Cerebral Speech Dominance: A Preliminary Report on the Intracarotid Injection of Sodium Amytal in Man , Med Biol (Tokyo) 14:221222, 1949. 2. Wada, J., and Rasmussen, T.: Intracarotid Injection of Sodium Amytal for the Lateralization of Cerebral Speech Dominance , J Neurosurg 17:226-282, 1960.Crossref 3. Perria, L.; Rosadini, G.; and Rossi, G. F.: Determination of Side of Cerebral Dominance with Amobarbital , Arch Neurol 4:173-181, 1961.Crossref 4. Rovit, R. L.; Gloor, P.; and Rasmussen, T.: Intracarotid Amobarbital in Epileptic Patients , Arch Neurol 5:606-626, 1961.Crossref 5. Werman, R.; Christoff, N.; and Anderson, P. J.: Neurological Changes with Intracarotid Amytal and Megimide in Man , J Neurol Neurosurg Psychiat 22:333-337, 1959.Crossref 6. Obrador, S.; Carrascosa, R.; and Carbonell, J.: Study of Some Motor Syndromes (Rigidity, Tremor, Spasticity and Hemidecortication) by the Carotid Amytal Test , J Neurosurg 18:507-511, 1961.Crossref 7. Kjellberg, R. N.: Discussion in Werman, R.; Christoff, N.; and Anderson, P. J.: Behavioral and EEG Changes Induced by Intracarotid Drugs , Trans Amer Neurol Ass 74-76, 1958.

Journal

Archives of NeurologyAmerican Medical Association

Published: Jun 1, 1963

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