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Therapeutic Problems in Cerebrovascular Disease: The Experimental Use of Plasmin in Dogs

Therapeutic Problems in Cerebrovascular Disease: The Experimental Use of Plasmin in Dogs Abstract What will drugs do towards ridding the patient of his paralysis? Nothing. No drugs can do anything whatever, good or bad, for cerebral softening. Softened brain is not brain at all; it is dirt in the brain. . . . He who is treating by drugs hemiplegia owing to softening or to a clot is treating a hole in the brain.—John Hughlings Jackson.12 References 1. Alpers, B. J.; Berry, R. G., and Paddison, R. M.: Anatomical Studies of the Circle of Willis in Normal Brain , A.M.A. Arch. Neurol. & Psychiat. 81:409-418, 1959. 2. Cobb, S.: The Cerebral Circulation: XIII. The Question of "End-Arteries" of the Brain, and Mechanism of Infarction , Arch. Neurol. & Psychiat. 25:273-280, 1931. 3. Cooper, A., cited by Hill.10 4. Critchley, M.: Jacksonian Ideas and the Future with Special Reference to Aphasia , Brit. M.J. 2:6-11, 1960. 5. Davidoff, L. M.: Intracranial Hemorrhage Associated with Hypertension and Arteriosclerosis , J. Neurosurg. 15:322-328, 1958. 6. DeBakay, M. E.; Crawford, E. S.; Cooley, D. A., and Morris, G. C., Jr.: Surgical Considerations of Occlusive Disease of Innominate, Carotid, Subclavian, and Vertebral Arteries , Ann. Surg. 149:690-710, 1959. 7. Denny-Brown, D.: Recurrent Cerebrovascular Symptoms of Vasospasm , A.M.A. Arch. Neurol. & Psychiat. 67:117-118, 1952. 8. Ellis, F. H., Jr.: Symposium on Surgical Treatment of Extracranial Occlusive Cerebrovascular Disease: Results of Surgical Treatment , Proc. Mayo Clin. 35:492-497, 1960. 9. Fishman, J. B., and Kline, D. L.: Isolation of Partially Purified Human Plasmin (Fibrinolysin) , Proc. Soc. Exp. Biol. Med. 91:323-325, 1956. 10. Hill, L.: On Cerebral Anemia and the Effects Which Follow Ligation of the Cerebral Arteries , Phil. Trans. Roy. Soc. London 193:69, 1900. 11. Hill, N. C.; Millikan, C. H.; Wakim, K., and Sayre, G. P.: Studies in Cerebrovascular Disease: VII. Experimental Production of Cerebral Infarction by Intracarotid Injection of Homologous Blood Clot: Preliminary Report , Proc. Mayo Clin. 30:625-633, 1955. 12. Jackson, J. H., cited by Critchley.4 13. Kety, S. S., and Schmidt, C. F.: The Nitrous Oxide Method for the Quantitative Determination of Cerebral Blood Flow in Man: Theory, Procedure, and Normal Values , J. Clin. Invest. 27:476-483, 1947. 14. Marshall, J., and Shaw, D. A.: Studies in Cerebrovascular Disease, presented at the National Hospital, Queen Square, as part of the centenary celebration, June, 1960. 15. Mettler, F. A.; Cooper, I.; Liss, H.; Carpenter, M., and Noback, C.: Patterns of Vascular Failure in the Central Nervous System , J. Neuropath. Exp. Neurol. 13:528-539, 1954. 16. Rosomoff, H. L.: Hypothermia and Cerebral Vascular Lesions: I. Experimental Interruption of the Middle Cerebral Artery During Hypothermia , J. Neurosurg. 13:332-343, 1956. 17. Scarcella, G.: Encephalomalacia Simulating the Clinical and Radiological Aspects of Brain Tumor: A Report of 6 Cases , J. Neurosurg. 13:366-380, 1956. 18. Scott, M.: The New Surgical Treatment of Spontaneous Hemorrhage Simulating Common Stroke , Ann. Intern. Med. 37:751-754, 1952. 19. Sibley, W. A.; Moreledge, J. H., and Lapham, L. W.: Experimental Cerebral Infarction: The Effects of Dicumarol , Amer. J. Med. Sci. 234:663-677, 1957. 20. Sokal, J. E.; Ambrus, J. L., and Ambrus, C. M.: Intravascular Clot Lysis with Fibrinolytic Enzymes: Clinical and Experimental Studies , Clin. Res. Proc. 5:154-155, 1957. 21. Stevens, H.: Carotid Artery Occlusion in Childhood , J. Pediat. 23:699-709, 1959. 22. Welch, K.: Excision of Occlusive Lesions of the Middle Cerebral Artery , J. Neurosurg. 13:73-80, 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Therapeutic Problems in Cerebrovascular Disease: The Experimental Use of Plasmin in Dogs

HORWITZ, NORMAN H.
Archives of Neurology , Volume 4 (4) – Apr 1, 1961
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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1961.00450100039006
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Abstract

Abstract What will drugs do towards ridding the patient of his paralysis? Nothing. No drugs can do anything whatever, good or bad, for cerebral softening. Softened brain is not brain at all; it is dirt in the brain. . . . He who is treating by drugs hemiplegia owing to softening or to a clot is treating a hole in the brain.—John Hughlings Jackson.12 References 1. Alpers, B. J.; Berry, R. G., and Paddison, R. M.: Anatomical Studies of the Circle of Willis in Normal Brain , A.M.A. Arch. Neurol. & Psychiat. 81:409-418, 1959. 2. Cobb, S.: The Cerebral Circulation: XIII. The Question of "End-Arteries" of the Brain, and Mechanism of Infarction , Arch. Neurol. & Psychiat. 25:273-280, 1931. 3. Cooper, A., cited by Hill.10 4. Critchley, M.: Jacksonian Ideas and the Future with Special Reference to Aphasia , Brit. M.J. 2:6-11, 1960. 5. Davidoff, L. M.: Intracranial Hemorrhage Associated with Hypertension and Arteriosclerosis , J. Neurosurg. 15:322-328, 1958. 6. DeBakay, M. E.; Crawford, E. S.; Cooley, D. A., and Morris, G. C., Jr.: Surgical Considerations of Occlusive Disease of Innominate, Carotid, Subclavian, and Vertebral Arteries , Ann. Surg. 149:690-710, 1959. 7. Denny-Brown, D.: Recurrent Cerebrovascular Symptoms of Vasospasm , A.M.A. Arch. Neurol. & Psychiat. 67:117-118, 1952. 8. Ellis, F. H., Jr.: Symposium on Surgical Treatment of Extracranial Occlusive Cerebrovascular Disease: Results of Surgical Treatment , Proc. Mayo Clin. 35:492-497, 1960. 9. Fishman, J. B., and Kline, D. L.: Isolation of Partially Purified Human Plasmin (Fibrinolysin) , Proc. Soc. Exp. Biol. Med. 91:323-325, 1956. 10. Hill, L.: On Cerebral Anemia and the Effects Which Follow Ligation of the Cerebral Arteries , Phil. Trans. Roy. Soc. London 193:69, 1900. 11. Hill, N. C.; Millikan, C. H.; Wakim, K., and Sayre, G. P.: Studies in Cerebrovascular Disease: VII. Experimental Production of Cerebral Infarction by Intracarotid Injection of Homologous Blood Clot: Preliminary Report , Proc. Mayo Clin. 30:625-633, 1955. 12. Jackson, J. H., cited by Critchley.4 13. Kety, S. S., and Schmidt, C. F.: The Nitrous Oxide Method for the Quantitative Determination of Cerebral Blood Flow in Man: Theory, Procedure, and Normal Values , J. Clin. Invest. 27:476-483, 1947. 14. Marshall, J., and Shaw, D. A.: Studies in Cerebrovascular Disease, presented at the National Hospital, Queen Square, as part of the centenary celebration, June, 1960. 15. Mettler, F. A.; Cooper, I.; Liss, H.; Carpenter, M., and Noback, C.: Patterns of Vascular Failure in the Central Nervous System , J. Neuropath. Exp. Neurol. 13:528-539, 1954. 16. Rosomoff, H. L.: Hypothermia and Cerebral Vascular Lesions: I. Experimental Interruption of the Middle Cerebral Artery During Hypothermia , J. Neurosurg. 13:332-343, 1956. 17. Scarcella, G.: Encephalomalacia Simulating the Clinical and Radiological Aspects of Brain Tumor: A Report of 6 Cases , J. Neurosurg. 13:366-380, 1956. 18. Scott, M.: The New Surgical Treatment of Spontaneous Hemorrhage Simulating Common Stroke , Ann. Intern. Med. 37:751-754, 1952. 19. Sibley, W. A.; Moreledge, J. H., and Lapham, L. W.: Experimental Cerebral Infarction: The Effects of Dicumarol , Amer. J. Med. Sci. 234:663-677, 1957. 20. Sokal, J. E.; Ambrus, J. L., and Ambrus, C. M.: Intravascular Clot Lysis with Fibrinolytic Enzymes: Clinical and Experimental Studies , Clin. Res. Proc. 5:154-155, 1957. 21. Stevens, H.: Carotid Artery Occlusion in Childhood , J. Pediat. 23:699-709, 1959. 22. Welch, K.: Excision of Occlusive Lesions of the Middle Cerebral Artery , J. Neurosurg. 13:73-80, 1956.

Journal

Archives of Neurology – American Medical Association

Published: Apr 1, 1961

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