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Comparative Effectiveness of Rhythm Control vs Rate Control Drug Treatment Effect on Mortality in Patients With Atrial Fibrillation

Comparative Effectiveness of Rhythm Control vs Rate Control Drug Treatment Effect on Mortality in... ORIGINAL INVESTIGATION Comparative Effectiveness of Rhythm Control vs Rate Control Drug Treatment Effect on Mortality in Patients With Atrial Fibrillation Raluca Ionescu-Ittu, PhD; Michal Abrahamowicz, PhD; Cynthia A. Jackevicius, MD, PhD; Vidal Essebag, MD, PhD; Mark J. Eisenberg, MD, MPH; Willy Wynant, MSc; Hugues Richard, MSc; Louise Pilote, MD, MPH, PhD Background: Controversy continues concerning the effect of rhythm vs rate control drugs changed over time: choice of rhythm control vs rate control treatment strat- after a small increase in mortality for patients treated with egies for atrial fibrillation (AF). A recent clinical trial rhythm control in the 6 months following treatment ini- showed no difference in 5-year mortality between the 2 tiation (hazard ratio [HR], 1.07; 95% CI, 1.01-1.14), the treatments. We aimed to determine whether the 2 strat- mortality was similar between the 2 groups until year 4 egies have similar effectiveness when applied to a general but decreased steadily in the rhythm control group after population of patients with AF with longer follow-up. year 5 (HR, 0.89; 95% CI, 0.81-0.96; and HR, 0.77; 95% CI, 0.62-0.95, after 5 and 8 years, respectively). Methods: We used population-based administrative da- tabases from Quebec, Canada, from 1999 to 2007 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Comparative Effectiveness of Rhythm Control vs Rate Control Drug Treatment Effect on Mortality in Patients With Atrial Fibrillation

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References (41)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2012.2266
pmid
22664954
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Comparative Effectiveness of Rhythm Control vs Rate Control Drug Treatment Effect on Mortality in Patients With Atrial Fibrillation Raluca Ionescu-Ittu, PhD; Michal Abrahamowicz, PhD; Cynthia A. Jackevicius, MD, PhD; Vidal Essebag, MD, PhD; Mark J. Eisenberg, MD, MPH; Willy Wynant, MSc; Hugues Richard, MSc; Louise Pilote, MD, MPH, PhD Background: Controversy continues concerning the effect of rhythm vs rate control drugs changed over time: choice of rhythm control vs rate control treatment strat- after a small increase in mortality for patients treated with egies for atrial fibrillation (AF). A recent clinical trial rhythm control in the 6 months following treatment ini- showed no difference in 5-year mortality between the 2 tiation (hazard ratio [HR], 1.07; 95% CI, 1.01-1.14), the treatments. We aimed to determine whether the 2 strat- mortality was similar between the 2 groups until year 4 egies have similar effectiveness when applied to a general but decreased steadily in the rhythm control group after population of patients with AF with longer follow-up. year 5 (HR, 0.89; 95% CI, 0.81-0.96; and HR, 0.77; 95% CI, 0.62-0.95, after 5 and 8 years, respectively). Methods: We used population-based administrative da- tabases from Quebec, Canada, from 1999 to 2007

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Jul 9, 2012

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