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ORIGINAL INVESTIGATION Comparative Effectiveness of Rhythm Control vs Rate Control Drug Treatment Effect on Mortality in Patients With Atrial Fibrillation Raluca Ionescu-Ittu, PhD; Michal Abrahamowicz, PhD; Cynthia A. Jackevicius, MD, PhD; Vidal Essebag, MD, PhD; Mark J. Eisenberg, MD, MPH; Willy Wynant, MSc; Hugues Richard, MSc; Louise Pilote, MD, MPH, PhD Background: Controversy continues concerning the effect of rhythm vs rate control drugs changed over time: choice of rhythm control vs rate control treatment strat- after a small increase in mortality for patients treated with egies for atrial fibrillation (AF). A recent clinical trial rhythm control in the 6 months following treatment ini- showed no difference in 5-year mortality between the 2 tiation (hazard ratio [HR], 1.07; 95% CI, 1.01-1.14), the treatments. We aimed to determine whether the 2 strat- mortality was similar between the 2 groups until year 4 egies have similar effectiveness when applied to a general but decreased steadily in the rhythm control group after population of patients with AF with longer follow-up. year 5 (HR, 0.89; 95% CI, 0.81-0.96; and HR, 0.77; 95% CI, 0.62-0.95, after 5 and 8 years, respectively). Methods: We used population-based administrative da- tabases from Quebec, Canada, from 1999 to 2007
JAMA Internal Medicine – American Medical Association
Published: Jul 9, 2012
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