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ORIGINAL INVESTIGATION HEALTH CARE REFORM Conflicts of Interest in Cardiovascular Clinical Practice Guidelines Todd B. Mendelson, MD, MBE; Michele Meltzer, MD, MBE; Eric G. Campbell, PhD; Arthur L. Caplan, PhD; James N. Kirkpatrick, MD Background: Clinical practice guidelines (CPGs) serve Results: Fifty-six percent of the 498 individuals as standards of care in practice, quality improvement, and reported a COI, corresponding to 56% of the 651 epi- reimbursement. The extent of conflicts of interest (COIs) sodes. Being a consultant or member of an advisory in cardiology guideline production has not been well stud- board was the most common type. The percentage of ied. Herein, we describe the scope of COIs in CPGs. episodes involving a COI varied between guidelines (range, 13%-87%). The number of episodes per indi- Methods:Weexaminedthe17mostrecentAmericanCol- vidual was associated with both presence and number lege of Cardiology/American Heart Association guidelines of disclosures (P.001 for both comparisons). Of 478 through 2008. Using disclosure lists, we cataloged COIs companies, the number per guideline ranged from 2 to for each participant as receiving a research grant, being 242 companies (mean, 38 companies). One company on a speaker’s bureau and/or receiving honoraria, own- was the most frequently reported company in 7 of
JAMA Internal Medicine – American Medical Association
Published: Mar 28, 2011
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