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Effectiveness of Implantable Cardioverter-Defibrillators for the Primary Prevention of Sudden Cardiac Death in Women With Advanced Heart Failure

Effectiveness of Implantable Cardioverter-Defibrillators for the Primary Prevention of Sudden... ORIGINAL INVESTIGATION Effectiveness of Implantable Cardioverter- Defibrillators for the Primary Prevention of Sudden Cardiac Death in Women With Advanced Heart Failure A Meta-analysis of Randomized Controlled Trials Hamid Ghanbari, MD; Ghassan Dalloul, MD; Reema Hasan, MD; Marcos Daccarett, MD, MSc; Souheil Saba, MD; Shukri David, MD; Christian Machado, MD Background: Numerous clinical trials have estab- failure that reported all-cause mortality as an outcome lished a role for implantable cardioverter-defibrillators for the female population. Of the 2619 reports identi- in the prevention of sudden cardiac death in patients with fied, 5 trials that enroll 934 women were included in the heart failure. However, questions remain that regard the meta-analysis. clinical benefit of these therapies in different patient sub- groups. Specifically, the role of implantable cardioverter- Results: Pooled data from the 5 trials revealed no sta- defibrillators in women with heart failure for the pri- tistically significant decrease in all-cause mortality in mary prevention of sudden cardiac death has not been women with heart failure who receive implantable car- well established. Our objective is to determine whether dioverter-defibrillators (hazard ratio, 1.01; 95% confi- implantable cardioverter-defibrillators reduce mortality dence interval, 0.76-1.33). in women with advanced heart failure. Conclusions: Implantable cardioverter-defibrillator Methods: We http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Effectiveness of Implantable Cardioverter-Defibrillators for the Primary Prevention of Sudden Cardiac Death in Women With Advanced Heart Failure

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References (52)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2009.255
pmid
19752408
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Effectiveness of Implantable Cardioverter- Defibrillators for the Primary Prevention of Sudden Cardiac Death in Women With Advanced Heart Failure A Meta-analysis of Randomized Controlled Trials Hamid Ghanbari, MD; Ghassan Dalloul, MD; Reema Hasan, MD; Marcos Daccarett, MD, MSc; Souheil Saba, MD; Shukri David, MD; Christian Machado, MD Background: Numerous clinical trials have estab- failure that reported all-cause mortality as an outcome lished a role for implantable cardioverter-defibrillators for the female population. Of the 2619 reports identi- in the prevention of sudden cardiac death in patients with fied, 5 trials that enroll 934 women were included in the heart failure. However, questions remain that regard the meta-analysis. clinical benefit of these therapies in different patient sub- groups. Specifically, the role of implantable cardioverter- Results: Pooled data from the 5 trials revealed no sta- defibrillators in women with heart failure for the pri- tistically significant decrease in all-cause mortality in mary prevention of sudden cardiac death has not been women with heart failure who receive implantable car- well established. Our objective is to determine whether dioverter-defibrillators (hazard ratio, 1.01; 95% confi- implantable cardioverter-defibrillators reduce mortality dence interval, 0.76-1.33). in women with advanced heart failure. Conclusions: Implantable cardioverter-defibrillator Methods: We

Journal

JAMA Internal Medicine – American Medical Association

Published: Sep 14, 2009

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