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The Role of Antioxidants on Risk for Cardiovascular Disease

The Role of Antioxidants on Risk for Cardiovascular Disease Abstract The article by Hoffman and Garewal,1 "Antioxidants and the Prevention of Coronary Heart Disease," was interesting and informative, and we would like to draw the authors' attention to some further information relating to the subject. Hoffman and Garewal state that the Prospective Basel Study was the only large cohort study that did not find an association between antioxidants and cardiovascular risk.2 A 12-year follow-up of this study found an inverse correlation of both carotene and vitamin C to cardiovascular risk.3 The relative risk (RR) for ischemic heart disease was 1.53 (P=.02) for a plasma carotene concentration below the first quartile. Similar results were obtained for a combination of both low carotene and vitamin C concentrations (RR=1.96, P=.022). Furthermore, low carotene and vitamin C concentrations were also associated with increased cerebrovascular deaths (RR=4.17, P<.01). A recently published study found that a combination of suboptimal levels of References 1. Hoffman RM, Garewal HS. Antioxidants and the prevention of coronary heart disease. Arch Intern Med . 1995;155:241-246.Crossref 2. Gey KF, Brubacher GB, Stähelin HB. Plasma levels of anti-oxidant vitamins in relation to ischemic heart disease and cancer. Am J Clin Nutr . 1987;45: 1368-1377. 3. Eichholzer M, Stähelin HB, Gey KF. Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease, and stroke, respectively: 12-year follow-up of the Prospective Basel Study. EXS . 1992;62:398-410. 4. Gey KF, Stähelin HB, Ballmer PE. Essential antioxidants in cardiovascular diseases: lessons for Europe [in German]. Ther Umsch . 1994;51:475-482. 5. Rath M, Pauling L. Hypothesis: lipoprotein(a) is a surrogate for ascorbate. Proc Natl Acad Sci U S A . 1990;87:6204-6207.Crossref 6. Wiseman H. Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances. Trends Pharmacol Sci . 1994;15:83-89.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

The Role of Antioxidants on Risk for Cardiovascular Disease

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1995.00430150181025
Publisher site
See Article on Publisher Site

Abstract

Abstract The article by Hoffman and Garewal,1 "Antioxidants and the Prevention of Coronary Heart Disease," was interesting and informative, and we would like to draw the authors' attention to some further information relating to the subject. Hoffman and Garewal state that the Prospective Basel Study was the only large cohort study that did not find an association between antioxidants and cardiovascular risk.2 A 12-year follow-up of this study found an inverse correlation of both carotene and vitamin C to cardiovascular risk.3 The relative risk (RR) for ischemic heart disease was 1.53 (P=.02) for a plasma carotene concentration below the first quartile. Similar results were obtained for a combination of both low carotene and vitamin C concentrations (RR=1.96, P=.022). Furthermore, low carotene and vitamin C concentrations were also associated with increased cerebrovascular deaths (RR=4.17, P<.01). A recently published study found that a combination of suboptimal levels of References 1. Hoffman RM, Garewal HS. Antioxidants and the prevention of coronary heart disease. Arch Intern Med . 1995;155:241-246.Crossref 2. Gey KF, Brubacher GB, Stähelin HB. Plasma levels of anti-oxidant vitamins in relation to ischemic heart disease and cancer. Am J Clin Nutr . 1987;45: 1368-1377. 3. Eichholzer M, Stähelin HB, Gey KF. Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease, and stroke, respectively: 12-year follow-up of the Prospective Basel Study. EXS . 1992;62:398-410. 4. Gey KF, Stähelin HB, Ballmer PE. Essential antioxidants in cardiovascular diseases: lessons for Europe [in German]. Ther Umsch . 1994;51:475-482. 5. Rath M, Pauling L. Hypothesis: lipoprotein(a) is a surrogate for ascorbate. Proc Natl Acad Sci U S A . 1990;87:6204-6207.Crossref 6. Wiseman H. Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances. Trends Pharmacol Sci . 1994;15:83-89.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Aug 7, 1995

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