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Cholesterol and Depression

Cholesterol and Depression Abstract Several articles have suggested that low total cholesterol levels are linked to changes in behavior; men with low cholesterol levels are associated with higher rates of suicide within 6 years of measurement,1 and lowering the cholesterol levels therapeutically by diets or drugs may lead to a rise in violent deaths.2 One explanation for these somewhat disturbing findings is that a low plasma cholesterol level leads to modifications of brain cholesterol concentration that, in turn, alter central nervous function.3 Recent findings are highly contradictory, some speaking for4-6 and some strongly against7 a relationship between blood lipid levels and psychologic variables. In this situation, a clinical study with a lipidlowering agent may lead further than epidemiologic evidence. We have undertaken a small pilot study quantifying psychologic variables in healthy volunteers during and after treatment with a fibrate. Nine healthy individuals gave informed consent to participate (six men References 1. Lindberg G, Rastam L, Gulberg B, Eklund GA. Low serum cholesterol concentration and short term mortality from injuries in men and women . BMJ . 1992;305:277-279.Crossref 2. Muldoon MF, Manuck SB, Mathews KA. Lowering cholesterol concentration and mortality: a quantitative review of primary prevention trials . BMJ . 1990; 301:309-314.Crossref 3. Engelberg H. Low serum cholesterol and suicide . Lancet . 1992;339:727-729.Crossref 4. Morgan RE, Palinkas LA, Barrett-Connor EL, Wingard DL. Plasma cholesterol and depressive symptoms in older men . Lancet . 1993;341:75-79.Crossref 5. Strandberg TE, Valvanne J, Tilvis RS. Serum lipids and depression . Lancet . 1993;341:433-434.Crossref 6. Dealberto MJ, Ducimetiere P, Mainard F, Alperovitch A. Serum lipids and depression . Lancet . 1993;341:435.Crossref 7. Weidner G, Connor SL, Hollis JF, Connor WE. Improvement in hostility and depression in relation to dietary change and cholesterol lowering . Ann Intern Med . 1992;117:820-823.Crossref 8. Ullrich RR. Das Emotionalitatsinventar . Munich, Germany: Pfeiffer; 1977. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Cholesterol and Depression

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Cholesterol and Depression

Abstract

Abstract Several articles have suggested that low total cholesterol levels are linked to changes in behavior; men with low cholesterol levels are associated with higher rates of suicide within 6 years of measurement,1 and lowering the cholesterol levels therapeutically by diets or drugs may lead to a rise in violent deaths.2 One explanation for these somewhat disturbing findings is that a low plasma cholesterol level leads to modifications of brain cholesterol concentration that, in turn,...
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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1994.00420100153025
Publisher site
See Article on Publisher Site

Abstract

Abstract Several articles have suggested that low total cholesterol levels are linked to changes in behavior; men with low cholesterol levels are associated with higher rates of suicide within 6 years of measurement,1 and lowering the cholesterol levels therapeutically by diets or drugs may lead to a rise in violent deaths.2 One explanation for these somewhat disturbing findings is that a low plasma cholesterol level leads to modifications of brain cholesterol concentration that, in turn, alter central nervous function.3 Recent findings are highly contradictory, some speaking for4-6 and some strongly against7 a relationship between blood lipid levels and psychologic variables. In this situation, a clinical study with a lipidlowering agent may lead further than epidemiologic evidence. We have undertaken a small pilot study quantifying psychologic variables in healthy volunteers during and after treatment with a fibrate. Nine healthy individuals gave informed consent to participate (six men References 1. Lindberg G, Rastam L, Gulberg B, Eklund GA. Low serum cholesterol concentration and short term mortality from injuries in men and women . BMJ . 1992;305:277-279.Crossref 2. Muldoon MF, Manuck SB, Mathews KA. Lowering cholesterol concentration and mortality: a quantitative review of primary prevention trials . BMJ . 1990; 301:309-314.Crossref 3. Engelberg H. Low serum cholesterol and suicide . Lancet . 1992;339:727-729.Crossref 4. Morgan RE, Palinkas LA, Barrett-Connor EL, Wingard DL. Plasma cholesterol and depressive symptoms in older men . Lancet . 1993;341:75-79.Crossref 5. Strandberg TE, Valvanne J, Tilvis RS. Serum lipids and depression . Lancet . 1993;341:433-434.Crossref 6. Dealberto MJ, Ducimetiere P, Mainard F, Alperovitch A. Serum lipids and depression . Lancet . 1993;341:435.Crossref 7. Weidner G, Connor SL, Hollis JF, Connor WE. Improvement in hostility and depression in relation to dietary change and cholesterol lowering . Ann Intern Med . 1992;117:820-823.Crossref 8. Ullrich RR. Das Emotionalitatsinventar . Munich, Germany: Pfeiffer; 1977.

Journal

Archives of Internal Medicine – American Medical Association

Published: May 23, 1994

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