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Vestibular Vertigo Associated With Hyperlipidemia: Response to Antilipidemic Therapy

Vestibular Vertigo Associated With Hyperlipidemia: Response to Antilipidemic Therapy Abstract Vestibular vertigo is a common recurrent syndrome, of multiple causes, whose incidence rises with advancing age. In spite of its clinical importance, it is not widely recognized that hyperlipidemia is one of the treatable causes of vestibular vertigo.1 Report of a Case. In 1988, a 63-year-old man was treated by me for a mixed hyperlipidemic disorder. During the previous 5 years, he had also suffered from recurrent vestibular vertigo, having six to eight spells per month, each spell lasting 1 to 72 hours and causing significant disability. Exhaustive evaluations and treatments by specialists, including trials of aspirin, meclizine, and dipyridamole, were ineffective. However, on treatment with lovastatin, the vertigo totally abated and did not recur. Encouraged, I began prescribing low-fat diets plus lipid-lowering medications to hyperlipidemic patients with disabling vestibular vertigo, when no other cause could be ascertained.Over a 5-year period, a total of 31 patients (12 men References 1. Baloh RW. Dizziness in older people . J Am Geriatr Soc. 1992;40:713-721. 2. Spencer JT. Hyperlipoproteinemia and inner ear disease . Otolaryngol Clin North Am. 1975;8:483-492. 3. Pillsbury HC. Hypertension, hyperlipoproteinemia, chronic noise exposure: is there synergism in cochlear pathology? Laryngoscope . 1986;96:1112-1138.Crossref 4. Nelson KR, Davis D. Vertigo of vascular origin . Arch Neurol. 1990;47:12-13. 5. Kroenke K, Lucas CA, Rosenberg ML, et al. Causes of persistent dizziness . Ann Intern Med. 1992;117:898-904.Crossref 6. Brandt T. Vertigo: Its Multisensory Syndromes . New York, NY: Springer-Verlag NY Inc; 1991. 7. Grad A, Baloh RW. Vertigo of vascular origin . Arch Neurol. 1989;46:281-284.Crossref 8. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis . Lancet . 1992;340:1111-1115.Crossref 9. Trouillas P, Nighoghossian N, Philippon B. Nuclear hemodynamic vertebrobasilar insufficiency: a new approach with the xenon 133 method . Arch Neurol. 1991;48:921-929.Crossref 10. Evans JG. Transient neurological dysfunction and risk of stroke in an elderly English population: the different significance of vertigo and non-rotatory dizziness . Age Aging. 1990;19:43-49.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Vestibular Vertigo Associated With Hyperlipidemia: Response to Antilipidemic Therapy

Saadah, Hanna A.
Archives of Internal Medicine , Volume 153 (15) – Aug 9, 1993
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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1993.00410150136014
Publisher site
See Article on Publisher Site

Abstract

Abstract Vestibular vertigo is a common recurrent syndrome, of multiple causes, whose incidence rises with advancing age. In spite of its clinical importance, it is not widely recognized that hyperlipidemia is one of the treatable causes of vestibular vertigo.1 Report of a Case. In 1988, a 63-year-old man was treated by me for a mixed hyperlipidemic disorder. During the previous 5 years, he had also suffered from recurrent vestibular vertigo, having six to eight spells per month, each spell lasting 1 to 72 hours and causing significant disability. Exhaustive evaluations and treatments by specialists, including trials of aspirin, meclizine, and dipyridamole, were ineffective. However, on treatment with lovastatin, the vertigo totally abated and did not recur. Encouraged, I began prescribing low-fat diets plus lipid-lowering medications to hyperlipidemic patients with disabling vestibular vertigo, when no other cause could be ascertained.Over a 5-year period, a total of 31 patients (12 men References 1. Baloh RW. Dizziness in older people . J Am Geriatr Soc. 1992;40:713-721. 2. Spencer JT. Hyperlipoproteinemia and inner ear disease . Otolaryngol Clin North Am. 1975;8:483-492. 3. Pillsbury HC. Hypertension, hyperlipoproteinemia, chronic noise exposure: is there synergism in cochlear pathology? Laryngoscope . 1986;96:1112-1138.Crossref 4. Nelson KR, Davis D. Vertigo of vascular origin . Arch Neurol. 1990;47:12-13. 5. Kroenke K, Lucas CA, Rosenberg ML, et al. Causes of persistent dizziness . Ann Intern Med. 1992;117:898-904.Crossref 6. Brandt T. Vertigo: Its Multisensory Syndromes . New York, NY: Springer-Verlag NY Inc; 1991. 7. Grad A, Baloh RW. Vertigo of vascular origin . Arch Neurol. 1989;46:281-284.Crossref 8. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis . Lancet . 1992;340:1111-1115.Crossref 9. Trouillas P, Nighoghossian N, Philippon B. Nuclear hemodynamic vertebrobasilar insufficiency: a new approach with the xenon 133 method . Arch Neurol. 1991;48:921-929.Crossref 10. Evans JG. Transient neurological dysfunction and risk of stroke in an elderly English population: the different significance of vertigo and non-rotatory dizziness . Age Aging. 1990;19:43-49.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Aug 9, 1993

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