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Gikas A Perrone C (1990)
Clarithromycin, sulfisoxasole and rifambutin activity against Mycobacterium avium complex multiplication within human macrophagesAntimicrob Agents Chemother., 34
Bruce Agins, Daniel Berman, D. Spicehandler, Wafaa El-Sadr, Michael Simberkoff, James Rahal (1989)
Effect of combined therapy with ansamycin, clofazimine, ethambutol, and isoniazid for Mycobacterium avium infection in patients with AIDS.The Journal of infectious diseases, 159 4
J. Chiu, Joseph Nussbaum, S. Bozzette, J. Tilles, Young Ls, J. Leedom, P. Heseltine, McCutchan Ja (1990)
Treatment of disseminated Mycobacterium avium complex infection in AIDS with amikacin, ethambutol, rifampin, and ciprofloxacin. California Collaborative Treatment Group.Annals of internal medicine, 113 5
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California Collaborative Treatment Group: treatment of disseminated Mycobacterium avium complex infection with amikacin, ethambutol, rifampin, and ciprofloxacinAnn Intern Med., 113
J. Hoy, A. Mijch, Murray Sandland, L. Grayson, Ron Lucas, B. Dwyer (1990)
Quadruple-drug therapy for Mycobacterium avium-intracellulare bacteremia in AIDS patients.The Journal of infectious diseases, 161 4
Destefano MS Klemens SP
Program and abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy
R. Chaisson, P. Hopewell (1989)
Mycobacteria and AIDS mortality.The American review of respiratory disease, 139 1
Horsburgh Cr, Selik Rm (1989)
The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immunodeficiency syndrome (AIDS).The American review of respiratory disease, 139
Ji B Truffot CH (1991)
Effect of pH on in vitro potency of clarithromycin against M avium complexAntimicrob Agents Chemother., 35
Prabhavathi Fernandes, Dwight Hardy, Donna McDANIEL, C. Hanson, Robert Swanson (1989)
In vitro and in vivo activities of clarithromycin against Mycobacterium aviumAntimicrobial Agents and Chemotherapy, 33
M. Wilkes, J. Felix, A. Fortin, T. Godwin, WarrenG. Thompson (1988)
VALUE OF NECROPSY IN ACQUIRED IMMUNODEFICIENCY SYNDROMEThe Lancet, 332
American Thoracic Society and Centers for Disease Control (1987)
Mycobacterioses and the acquired immune deficiency syndrome: joint position paperAm Rev Respir Dis., 136
Truffot C Dautzenberg B (1991)
Activity of clarithromycin against Mycobacterium avium infection in patients with the acquired immune deficiency syndromeAm Rev Respir Dis., 144
L. Heifets, M. Iseman, P. Lindholm-Levy (1988)
Combinations of rifampin or rifabutine plus ethambutol against Mycobacterium avium complex. Bactericidal synergistic, and bacteriostatic additive or synergistic effects.The American review of respiratory disease, 137 3
C. Truffot-Pernot, B. Ji, J. Grosset (1991)
Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complexAntimicrobial Agents and Chemotherapy, 35
C. Perronne, A. Gikas, C. Truffot-Pernot, J. Grosset, Jean-Jacques Pocidalo, Jean‐Louis Vildé (1990)
Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophagesAntimicrobial Agents and Chemotherapy, 34
L. Young (1988)
Mycobacterium avium complex infection.The Journal of infectious diseases, 157 5
British Medical Research Council (1948)
Investigation of streptomycin in the treatment of pulmonary tuberculosisBMJ., 2
B. Dautzenberg, C. Truffot, A. Mignon, Willy Rozenbaum, Christine Katlama, Ch. Perronne, R. Parrot, Jacques Grosset (1991)
Rifabutin in combination with clofazimine, isoniazid and ethambutol in the treatment of AIDS patients with infections due to opportunist mycobacteria. Groupe d'Etude et de Traitement des Infections à Mycobacteries Résistantes.Tubercle, 72 3
Truffot C Dautzenberg B (1991)
Rifabutin in combination with clofazimine, isoniazid, and ethambutol in the treatment of AIDS patients with infections due to opportunistic mycobacteriaTubercle, 72
C. Truffot-Pernot, H. Lecoeur, L. Maury, B. Dautzenberg, J. Grosset (1989)
Results of blood cultures for detection of mycobacteria in AIDS patients.Tubercle, 70 3
J. Wallace, J. Hannah (1988)
Mycobacterium avium complex infection in patients with the acquired immunodeficiency syndrome. A clinicopathologic study.Chest, 93 5
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Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome.Annals of internal medicine, 105 2
Abstract Background: Disseminated infection with Mycobacterium avium is common with late-stage acquired immunodeficiency syndrome (AIDS), and no antimicrobial agent has been found to be clearly effective. Methods: A multicenter open trial was conducted to assess the antimicrobial activity and clinical efficacy of clarithromycin—a new macrolide antibiotic—against disseminated M avium in 77 patients with late-stage AIDS. Blood cultures were taken at baseline and during treatment; side effects were also evaluated. Results: Mycobacterium avium was eradicated from blood cultures in 11 (63%) of 16 evaluable patients receiving daily doses or 500 or 1000 mg, (n=21) and in 45 of 46 (98%) of those receiving 1500 or 2000 mg (n=56). Eradication after 2 months was influenced by continuity of drug treatment; 36 of 42 patients with no relapse had received continuous treatment vs six of 14 patients whose drug treatment had been stopped for 7 days or longer. After 2 to 7 months of treatment, acquired resistance associated with relapse was observed. Drug side effects were elevated liver enzyme levels (26%) and impaired hearing (4%). Concomitant AIDS drugs had no favorable effect on outcome and may have worsened liver toxicity. Conclusions: Clarithromycin has bacteriologic efficacy against M avium infection in late-stage AIDS, although drug resistance eventually develops. Further studies are needed to investigate safe, effective concomitant drugs.(Arch Intern Med. 1993;153:368-372) References 1. Wilkes MS, Fortin AH, Felix JC, Godwin TA, Thompson WG. Value of necropsy in acquired immunodeficiency syndrome . Lancet. 1988;2:85-88.Crossref 2. Wallace JM, Hannah JB. Mycobacterium avium complex infection in patients with the acquired immunodeficiency syndrome: a clinicopathologic study . Chest. 1988;93:926-932.Crossref 3. American Thoracic Society and Centers for Disease Control. Mycobacterioses and the acquired immune deficiency syndrome: joint position paper . Am Rev Respir Dis. 1987;136:492-496.Crossref 4. Horsburgh CR, Selik RM. The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immune deficiency syndrome . Am Rev Respir Dis. 1989;139:4-7.Crossref 5. Chaisson RE, Hopewell PC. Mycobacteria and AIDS mortality . Am Rev Respir Dis. 1989;139:1-3.Crossref 6. Heifets LB, Iseman MD, Lindholm-Levy PJ. Combination of rifampin or rifabutine plus ethambutol against Mycobacterium avium complex: bactericidal synergistic, and bacteriostatic additive or synergistic effects . Am Rev Respir Dis. 1988;137:711-715.Crossref 7. Agins BD, Berman DS, Spicehandler D, El Sadr W, Simberkoff MS, Rahal JJ. Effect of combined therapy with ansamycin, clofazimine, ethambutol and isoniazid for Mycobacterium avium infection in patients with AIDS . J Infect Dis. 1989;159:784-787.Crossref 8. Hawkins CC, Gold JWM, Whimbey E, et al. Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome . Ann Intern Med. 1986;105:184-188.Crossref 9. Young LS. Mycobacterium avium complex infection . J Infect Dis. 1988;157: 863-867.Crossref 10. Hoy J, Mijch A. Sandlum M, Grayson L, Lucas R, Dwyer B. Quadruple-drug therapy for Mycobacterium avium intracellulare bacteremia in AIDS patients . J Infect Dis. 1990;161:801-805.Crossref 11. Chiu J, Nussbaum J, Bozzette S, et al. California Collaborative Treatment Group: treatment of disseminated Mycobacterium avium complex infection with amikacin, ethambutol, rifampin, and ciprofloxacin . Ann Intern Med. 1990;113:358-361.Crossref 12. Young LS, Wiviott L, Wu M, Kolonosky P, Inderlied CB, Bolan R. Azithromycin reduces M avium complex (MAC) bacteria and relieves its symptoms in patients with AIDS . In: Program and abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy; September 9, 1991 ; Chicago, III. Abstract 293. 13. Dautzenberg B, Truffot C, Mignon A, et al. Rifabutin in combination with clofazimine, isoniazid, and ethambutol in the treatment of AIDS patients with infections due to opportunistic mycobacteria . Tubercle . 1991;72:168-175.Crossref 14. Dautzenberg B, Truffot C, Legris S, et al. Activity of clarithromycin against Mycobacterium avium infection in patients with the acquired immune deficiency syndrome . Am Rev Respir Dis. 1991;144:564-569.Crossref 15. Fernandes PB, Hardy DJ, McDaniel D, Hanson CW, Swanson RN. In vitro and in vivo activities of clarithromycin against Mycobacterium avium . Antimicrob Agents Chemother. 1989;33:1531-1534.Crossref 16. Perrone C, Gikas A, Truffot-Pernot C, Grosset J, Pociadalo JJ, Vilde JL. Clarithromycin, sulfisoxasole and rifambutin activity against Mycobacterium avium complex multiplication within human macrophages . Antimicrob Agents Chemother. 1990;34:1508-1511.Crossref 17. Ji B, Lounis N, Truffot-Pernot C, Grosset JH. Susceptibility of the immunocompetent, beige, and nude mice to Mycobacterium avium infection and iresponse to clarithromycin . In: Program and abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy; September 9, 1991 ; Chicago, III. Abstract 291. 18. Klemens SP, Destefano MS, Cynamon MH. Clarithromycin in combination with other agents against M avium complex (MAC) in beige mice . In: Program and abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy; September 9, 1991 ; Chicago, Ill. Abstract 292. 19. Truffot-Pernot C, Lecoeur H, Maury L, Dautzenberg B, Grosset J. Results of blood cultures for detection of mycobacteria in AIDS patients . Tubercle. 1989; 70:187-191.Crossref 20. Truffot CH, Ji B, Grosset J. Effect of pH on in vitro potency of clarithromycin against M avium complex . Antimicrob Agents Chemother. 1991;35:1677-1678.Crossref 21. British Medical Research Council. Investigation of streptomycin in the treatment of pulmonary tuberculosis . BMJ. 1948;2:769-782.Crossref
Archives of Internal Medicine – American Medical Association
Published: Feb 8, 1993
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