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Renal Cell Carcinoma Following Prolonged Testosterone Therapy

Renal Cell Carcinoma Following Prolonged Testosterone Therapy Abstract To the Editor. — The cause of renal cell carcinoma is not well understood although chemical carcinogens, radiation, hormones, heredity, and viruses have all been implicated.1 We recently cared for a patient born with ambiguous genitalia treated for 2 years with testosterone, who presented at the relatively young age of 22 years. Report of a Case.— The patient was born with ambiguous genitalia. His chromosomal sex was male, and he underwent several surgical procedures on his genitalia in infancy to make him an anatomical male. He was treated with testosterone, both orally and parenterally, for 2 or more years following these surgical procedures. At age 22 years, the patient presented with flank pain, hematuria, and a right renal mass that on biopsy was found to be poorly differentiated adenocarcinoma of the kidney. At presentation, he already had widespread metastatic disease to the liver, pleura, retroperitoneum, and elsewhere. He had References 1. Outzen HC, Maguire HC Jr. The etiology of renal-cell carcinoma . Semin Oncol. 1983;10:378-384. 2. Horning ES. Observations on hormone-dependent renal tumors in the golden hamster . Br J Cancer. 1956;10:678-687.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Renal Cell Carcinoma Following Prolonged Testosterone Therapy

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1992.00400140156043
Publisher site
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Abstract

Abstract To the Editor. — The cause of renal cell carcinoma is not well understood although chemical carcinogens, radiation, hormones, heredity, and viruses have all been implicated.1 We recently cared for a patient born with ambiguous genitalia treated for 2 years with testosterone, who presented at the relatively young age of 22 years. Report of a Case.— The patient was born with ambiguous genitalia. His chromosomal sex was male, and he underwent several surgical procedures on his genitalia in infancy to make him an anatomical male. He was treated with testosterone, both orally and parenterally, for 2 or more years following these surgical procedures. At age 22 years, the patient presented with flank pain, hematuria, and a right renal mass that on biopsy was found to be poorly differentiated adenocarcinoma of the kidney. At presentation, he already had widespread metastatic disease to the liver, pleura, retroperitoneum, and elsewhere. He had References 1. Outzen HC, Maguire HC Jr. The etiology of renal-cell carcinoma . Semin Oncol. 1983;10:378-384. 2. Horning ES. Observations on hormone-dependent renal tumors in the golden hamster . Br J Cancer. 1956;10:678-687.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Feb 1, 1992

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