Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A Comparison of Home Glucose Monitoring With Determinations of Hemoglobin A1c, Total Glycated Hemoglobin, Fructosamine, and Random Serum Glucose in Diabetic Patients

A Comparison of Home Glucose Monitoring With Determinations of Hemoglobin A1c, Total Glycated... Abstract We compared four objective measures of glycemic control (fructosamine, total glycated hemoglobin, hemoglobin A1c, and random serum glucose) with home glucose monitoring records in 17 diabetic patients followed up prospectively for 4 months. There was good overall correlation between all of these objective measures and weekly mean capillary glucose values. However, considerable scatter was seen in the data such that none of the glycated protein measurements was an ideal predictor of home glucose values. For example, all markedly elevated home glucose levels (>11.1 mmoI/L) were associated with elevated glycated protein levels, but moderately high blood glucose levels (8.3 to 11.1 mmol/L) were associated with one or more normal glycated protein values in some patients. Similar correlations were obtained whether glycemia was estimated by 1-week or 6-week home averages. Random serum glucose level also correlated with average home glucose level; however, there was wide fluctuation within individual subjects. All three glycated protein measurements (hemoglobin A1c, glycated hemoglobin, and fructosamine) appear equally useful as a supplement to home glucose monitoring in the assessment of glycemic control. Of the three types of glycated protein assays, fructosamine, with its advantage of speed and simplicity, may offer a more cost-effective alternative. (Arch Intern Med. 1991;151:1133-1137) References 1. Pecoraro RE, Koepsell TD, Chen MS, Lipsy BA, Belcher DW, Inui TS. Comparative clinical reliability of fasting plasma glucose and glycosylated hemoglobin in non-insulin-dependent diabetes mellitus . Diabetes Care. 1986;9:370-375.Crossref 2. Service FJ, Nelson RL. Characteristics of glycemic stability . Diabetes Care. 1980;3:58-62.Crossref 3. Mazze RS, Shamoon H, Pasmantier R, Lucido D, Murphy J. Reliability of blood glucose monitoring by patients with diabetes mellitus . Am J Med. 1984;77:211-217.Crossref 4. Consensus statement on self-monitoring of blood glucose . Diabetes Care. 1987;10:95-99. 5. Miedama K, Casparic T. Glycosylated hemoglobin: biochemical and clinical utility . Ann Clin Biochem. 1984;21:2-15.Crossref 6. Goldstein DE, Parker M, England JD, et al. Clinical application of glycosylated hemoglobin measurements . Diabetes. 1982;31( (suppl 3) ):70-78.Crossref 7. Nathan DM, Singer DE, Hurxthal K, Goodson JD. The clinical information value of the glycosylated hemoglobin assay . N Engl J Med. 1984;310:341-344.Crossref 8. Health and Public Policy Committee, American College of Physicians. Glycosylated hemoglobin assays in the management and diagnosis of diabetes mellitus . Ann Intern Med. 1984;101:710-713.Crossref 9. Johnson RN, Metcalf PA, Baker JR. Fructosamine: a new approach to the estimation of serum glycosylprotein: an index of diabetic control . Clin Chem Acta. 1982;127:87-95.Crossref 10. Baker JR, Johnson RN, Scott DJ. Serum fructosamine concentrations in patients with type II (non-insulin-dependent) diabetes mellitus during changes in management . BMJ. 1984;288:1484-1486.Crossref 11. Hindle EJ, Rostzon GM, Clark SA, Gatt JA. Serum fructosamine and glycated hemoglobin measurements in diabetic control . Arch Dis Childhood. 1986;61:113-117.Crossref 12. Lim YS, Staley MJ. Measurement of plasma fructosamine evaluated for monitoring diabetes . Clin Chem. 1985;31:731-733. 13. Winocour PH, Bhatnagar D, Kalsi P, Hillier VF, Anderson DC. Relative clinical usefulness of glycosylated serum albumin and fructosamine during short-term changes in glycemic control in IDDM . Diabetes Care. 1989;12:665-672.Crossref 14. Mullis P, Volkle H, Sigrist V, Zuppinger K. Comparison of fructosamine and glycated hemoglobin in children with type I (insulin-dependent) diabetes mellitus . Diabetologia. 1988;31:351-354.Crossref 15. Mallia AK, Hermanson GT, Krohn RI, Fujimoto EK, Smith PK. Preparation and use of a boronic acid affinity support for separation and quantitation of glycated hemoglobins . Anal Lett. 1981;14:649-661.Crossref 16. Baker JR, O'Conner JP, Metcalf PA, Lawson MR, Johnson RN. Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus . BMJ. 1983;287:863-867.Crossref 17. Papadea C, Austin GE, Mullins RE. The effect of storage conditions on ion exchange and affinity chromatographic assays for glycated hemoglobins . Clin Biochem. 1984;17:296-301.Crossref 18. Lawley DN. On testing a set of correlation coefficients for equality . Ann Math Statist. 1963;34:149-151.Crossref 19. Koschinsy T, Dannehl K, Gries FA. New approach to technical and clinical evaluation of devices for self-monitoring of blood glucose . Diabetes Care. 1988;11:619-629.Crossref 20. Ziegler 0, Kolopp M, Got I, Gentron P, Debry G, Drovin P. Reliability of self-monitoring of blood glucose by CSII-treated patients with type I diabetes . Diabetes Care. 1989;12:184-188.Crossref 21. Svendsen PA, Lauritzen T, Soegaard U, Nerup J. Glycosylated hemoglobin and steady state mean blood glucose concentration in type I (insulindependent) diabetes . Diabetologia. 1982;23:403-405. 22. Cefalu WT, Parker TB, Johnson CR. Validity of serum fructosamine as index of short-term glycemic control in diabetic outpatients . Diabetes Care. 1988;11:662-664. 23. Negoro H, Morley JE, Rosenthal MJ. Utility of serum fructosamine as a measure of glycemia in young and old diabetic and non-diabetic subjects . Am J Med. 1988;85:360-365.Crossref 24. Austin GE, Mullins RE, Morin LG. Non-enzymic glycation of individual plasma proteins in normoglycemic and hyperglycemic patients . Clin Chem. 1987;33:2220-2224. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

A Comparison of Home Glucose Monitoring With Determinations of Hemoglobin A1c, Total Glycated Hemoglobin, Fructosamine, and Random Serum Glucose in Diabetic Patients

Download PDF
5 pages

Loading next page...
 
/lp/american-medical-association/a-comparison-of-home-glucose-monitoring-with-determinations-of-CWsjbU6zi2

References (26)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1991.00400060071012
Publisher site
See Article on Publisher Site

Abstract

Abstract We compared four objective measures of glycemic control (fructosamine, total glycated hemoglobin, hemoglobin A1c, and random serum glucose) with home glucose monitoring records in 17 diabetic patients followed up prospectively for 4 months. There was good overall correlation between all of these objective measures and weekly mean capillary glucose values. However, considerable scatter was seen in the data such that none of the glycated protein measurements was an ideal predictor of home glucose values. For example, all markedly elevated home glucose levels (>11.1 mmoI/L) were associated with elevated glycated protein levels, but moderately high blood glucose levels (8.3 to 11.1 mmol/L) were associated with one or more normal glycated protein values in some patients. Similar correlations were obtained whether glycemia was estimated by 1-week or 6-week home averages. Random serum glucose level also correlated with average home glucose level; however, there was wide fluctuation within individual subjects. All three glycated protein measurements (hemoglobin A1c, glycated hemoglobin, and fructosamine) appear equally useful as a supplement to home glucose monitoring in the assessment of glycemic control. Of the three types of glycated protein assays, fructosamine, with its advantage of speed and simplicity, may offer a more cost-effective alternative. (Arch Intern Med. 1991;151:1133-1137) References 1. Pecoraro RE, Koepsell TD, Chen MS, Lipsy BA, Belcher DW, Inui TS. Comparative clinical reliability of fasting plasma glucose and glycosylated hemoglobin in non-insulin-dependent diabetes mellitus . Diabetes Care. 1986;9:370-375.Crossref 2. Service FJ, Nelson RL. Characteristics of glycemic stability . Diabetes Care. 1980;3:58-62.Crossref 3. Mazze RS, Shamoon H, Pasmantier R, Lucido D, Murphy J. Reliability of blood glucose monitoring by patients with diabetes mellitus . Am J Med. 1984;77:211-217.Crossref 4. Consensus statement on self-monitoring of blood glucose . Diabetes Care. 1987;10:95-99. 5. Miedama K, Casparic T. Glycosylated hemoglobin: biochemical and clinical utility . Ann Clin Biochem. 1984;21:2-15.Crossref 6. Goldstein DE, Parker M, England JD, et al. Clinical application of glycosylated hemoglobin measurements . Diabetes. 1982;31( (suppl 3) ):70-78.Crossref 7. Nathan DM, Singer DE, Hurxthal K, Goodson JD. The clinical information value of the glycosylated hemoglobin assay . N Engl J Med. 1984;310:341-344.Crossref 8. Health and Public Policy Committee, American College of Physicians. Glycosylated hemoglobin assays in the management and diagnosis of diabetes mellitus . Ann Intern Med. 1984;101:710-713.Crossref 9. Johnson RN, Metcalf PA, Baker JR. Fructosamine: a new approach to the estimation of serum glycosylprotein: an index of diabetic control . Clin Chem Acta. 1982;127:87-95.Crossref 10. Baker JR, Johnson RN, Scott DJ. Serum fructosamine concentrations in patients with type II (non-insulin-dependent) diabetes mellitus during changes in management . BMJ. 1984;288:1484-1486.Crossref 11. Hindle EJ, Rostzon GM, Clark SA, Gatt JA. Serum fructosamine and glycated hemoglobin measurements in diabetic control . Arch Dis Childhood. 1986;61:113-117.Crossref 12. Lim YS, Staley MJ. Measurement of plasma fructosamine evaluated for monitoring diabetes . Clin Chem. 1985;31:731-733. 13. Winocour PH, Bhatnagar D, Kalsi P, Hillier VF, Anderson DC. Relative clinical usefulness of glycosylated serum albumin and fructosamine during short-term changes in glycemic control in IDDM . Diabetes Care. 1989;12:665-672.Crossref 14. Mullis P, Volkle H, Sigrist V, Zuppinger K. Comparison of fructosamine and glycated hemoglobin in children with type I (insulin-dependent) diabetes mellitus . Diabetologia. 1988;31:351-354.Crossref 15. Mallia AK, Hermanson GT, Krohn RI, Fujimoto EK, Smith PK. Preparation and use of a boronic acid affinity support for separation and quantitation of glycated hemoglobins . Anal Lett. 1981;14:649-661.Crossref 16. Baker JR, O'Conner JP, Metcalf PA, Lawson MR, Johnson RN. Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus . BMJ. 1983;287:863-867.Crossref 17. Papadea C, Austin GE, Mullins RE. The effect of storage conditions on ion exchange and affinity chromatographic assays for glycated hemoglobins . Clin Biochem. 1984;17:296-301.Crossref 18. Lawley DN. On testing a set of correlation coefficients for equality . Ann Math Statist. 1963;34:149-151.Crossref 19. Koschinsy T, Dannehl K, Gries FA. New approach to technical and clinical evaluation of devices for self-monitoring of blood glucose . Diabetes Care. 1988;11:619-629.Crossref 20. Ziegler 0, Kolopp M, Got I, Gentron P, Debry G, Drovin P. Reliability of self-monitoring of blood glucose by CSII-treated patients with type I diabetes . Diabetes Care. 1989;12:184-188.Crossref 21. Svendsen PA, Lauritzen T, Soegaard U, Nerup J. Glycosylated hemoglobin and steady state mean blood glucose concentration in type I (insulindependent) diabetes . Diabetologia. 1982;23:403-405. 22. Cefalu WT, Parker TB, Johnson CR. Validity of serum fructosamine as index of short-term glycemic control in diabetic outpatients . Diabetes Care. 1988;11:662-664. 23. Negoro H, Morley JE, Rosenthal MJ. Utility of serum fructosamine as a measure of glycemia in young and old diabetic and non-diabetic subjects . Am J Med. 1988;85:360-365.Crossref 24. Austin GE, Mullins RE, Morin LG. Non-enzymic glycation of individual plasma proteins in normoglycemic and hyperglycemic patients . Clin Chem. 1987;33:2220-2224.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jun 1, 1991

There are no references for this article.