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A Severe Multisystem Reaction to Sulindac

A Severe Multisystem Reaction to Sulindac Abstract We present a case of a severe reaction to sulindac. A 30-year-old woman with quiescent systemic lupus erythematosus received sulindac for nonspecific migrating chest pain. An initial course of therapy produced an unrecognized sensitization to the drug with a febrile illness and rash. Readministration of the drug caused an anaphylactoid reaction as well as evidence of cardiovascular, hepatic, pulmonary, and hematologic dysfunction. The patient's illness had evidence of types I, II, and III hypersensitivity reactions. (Arch Intern Med. 1991;151:387-388) References 1. Simon LS, Mills JA. Nonsteroidal antiinflammatory drugs . N Engl J Med. 1980;302:1237-1238.Crossref 2. Drugs for rheumatoid arthritis . Med Lett. 1987;29:21-24. 3. Wells JV. Immune mechanisms in tissue damage . In: Stites DP, Stobu JD, Fudenberg HM, Wells JV, eds. Basic and Clinical Immunology . Los Altos, Calif: Lange Medical Publications; 1982:132. 4. Anderson JA, Adkinson NF. Allergic reactions to drugs and biologic agents . JAMA. 1987;258:2891-2899.Crossref 5. Terr AI. Allergic diseases . In: Stites DP, Stobu JD, Fudenberg HM, Wells JV, eds. Basic and Clinical Immunology . Los Altos, Calif: Lance Medical Publications; 1982:511-512. 6. Burrish GF, Kaatz BL. Sulindac-induced anaphylaxis . Ann Emerg Med. 1981;10:154-155.Crossref 7. Jett GK, Wilson E. Anaphylactic reaction associated with sulindac . Ann Emerg Med. 1984;13:462-464.Crossref 8. Levites R, Hafitz G. Febrile reaction to sulindac . JAMA. 1981;246:213-214.Crossref 9. Smith FE, Lindberg PJ. Life-threatening hypersensitivity to Sulindac . JAMA. 1980;244:269-270.Crossref 10. Park GD, Spector R, Headstream T, Goldberg M. Serious adverse reactions associated with sulindac . Arch Intern Med. 1982;142:1292-1294.Crossref 11. Dhand AK, La Brecque DR, Metzger J. Sulindac (Clinoril) hepatitis . Gastroenterology. 1981;80:585-586. 12. Anderson RJ. Severe reaction associated with sulindac administration . N Engl J Med. 1979;300:735-736.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

A Severe Multisystem Reaction to Sulindac

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1991.00400020127027
Publisher site
See Article on Publisher Site

Abstract

Abstract We present a case of a severe reaction to sulindac. A 30-year-old woman with quiescent systemic lupus erythematosus received sulindac for nonspecific migrating chest pain. An initial course of therapy produced an unrecognized sensitization to the drug with a febrile illness and rash. Readministration of the drug caused an anaphylactoid reaction as well as evidence of cardiovascular, hepatic, pulmonary, and hematologic dysfunction. The patient's illness had evidence of types I, II, and III hypersensitivity reactions. (Arch Intern Med. 1991;151:387-388) References 1. Simon LS, Mills JA. Nonsteroidal antiinflammatory drugs . N Engl J Med. 1980;302:1237-1238.Crossref 2. Drugs for rheumatoid arthritis . Med Lett. 1987;29:21-24. 3. Wells JV. Immune mechanisms in tissue damage . In: Stites DP, Stobu JD, Fudenberg HM, Wells JV, eds. Basic and Clinical Immunology . Los Altos, Calif: Lange Medical Publications; 1982:132. 4. Anderson JA, Adkinson NF. Allergic reactions to drugs and biologic agents . JAMA. 1987;258:2891-2899.Crossref 5. Terr AI. Allergic diseases . In: Stites DP, Stobu JD, Fudenberg HM, Wells JV, eds. Basic and Clinical Immunology . Los Altos, Calif: Lance Medical Publications; 1982:511-512. 6. Burrish GF, Kaatz BL. Sulindac-induced anaphylaxis . Ann Emerg Med. 1981;10:154-155.Crossref 7. Jett GK, Wilson E. Anaphylactic reaction associated with sulindac . Ann Emerg Med. 1984;13:462-464.Crossref 8. Levites R, Hafitz G. Febrile reaction to sulindac . JAMA. 1981;246:213-214.Crossref 9. Smith FE, Lindberg PJ. Life-threatening hypersensitivity to Sulindac . JAMA. 1980;244:269-270.Crossref 10. Park GD, Spector R, Headstream T, Goldberg M. Serious adverse reactions associated with sulindac . Arch Intern Med. 1982;142:1292-1294.Crossref 11. Dhand AK, La Brecque DR, Metzger J. Sulindac (Clinoril) hepatitis . Gastroenterology. 1981;80:585-586. 12. Anderson RJ. Severe reaction associated with sulindac administration . N Engl J Med. 1979;300:735-736.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Feb 1, 1991

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