Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The Association of Hepatitis Delta Virus and Hepatitis B Virus in Parenteral Drug Abusers: 1971 to 1972 and 1986 to 1987

The Association of Hepatitis Delta Virus and Hepatitis B Virus in Parenteral Drug Abusers: 1971... Abstract • From 1971 to 1972 (N=105) and 1986 to 1987 (N=160), parenteral drug abusers seropositive for hepatitis B virus (HBV) markers were screened for antibodies to the hepatitis delta virus (anti-HD). In both time frames anti-HD was independently associated with the hepatitis B surface antigen. It was observed that 31% of those positive for hepatitis B surface antigen from the early sample and 20% of those from the latter sample had detectable anti-HD, as opposed to 10% and 7%, respectively, of those negative for hepatitis B surface antigen. Anti-HD seropositivity was unrelated to gender and ethnicity, and in the 1971 and 1972 nationwide sample, its presence was unrelated to geographic location. The probability of manifesting anti-HD increased with the more HBV markers detected, particularly the number of different HBV antibody markers. We conclude that anti-HD was widespread in parenteral drug abusers at least as early as 1971, and that its expression was associated with hepatitis B surface antigen and the intensity of the immune response to HBV as evidenced by the number of different circulating HBV antibodies. (Arch Intern Med. 1990;150:365-368) References 1. Iwarson SA. Chronic hepatitis B . In: Gerety RJ, ed. Hepatitis B . Orlando, Fla: Academic Press Inc; 1985:129. 2. Junge V, Deinhardt F. The acute manifestations of hepatitis B virus infection . In: Gerety RJ, ed. Hepatitis B . Orlando, Fla: Academic Press Inc; 1985:103. 3. Jacobson IM, Dienstag JL, Werner BG, Brettler DB, Levine PH, Mushahwar IK. Epidemiology and clinical impact of hepatitis D virus (delta) infection . Hepatology . 1985;5:188-191.Crossref 4. Ponzetto A, Seeff LB, Buskell-Bales Z, et al. Hepatitis B markers in United States drug addicts with special emphasis on the delta hepatitis virus . Hepatology . 1984;4:1111-1115.Crossref 5. Nishioka NS, Dienstag JL. Delta hepatitis: a new scourge? N Engl J Med . 1985;312:1515-1516.Crossref 6. Kunches MM, Craven DE, Werner BG. Seroprevalence of hepatitis B virus and delta agent in parenteral drug abusers: immunogenecity of hepatitis B vaccine . Am J Med . 1986;81:591-595.Crossref 7. Rodriguez M, Perez R, Sala P, Rodrigo L. Hepatitis B markers in United States drug addicts with special emphasis on the delta hepatitis virus . Hepatology . 1986;6:155.Crossref 8. Seeff LB, Ponzetto A, Hoofnagle JH, Gerin JL. Hepatitis B markers in United States addicts with special emphasis on the delta hepatitis virus . Hepatology . 1986;6:155-156.Crossref 9. Lange WR, Snyder FR, Lozovsky D, Kaistha V, Kaczaniuk MA, Jaffe JH. HIV infection in Baltimore: antibody seroprevalence rates among parenteral drug abusers and prostitutes . Md Med J . 1987;36:757-761. 10. Lange WR, Snyder FR, Lozovsky D, et al. Geographic distribution of human immunodeficiency virus markers in parenteral drug abusers . Am J Public Health . 1988;78:443-446.Crossref 11. Moore JD. Serologic markers of hepatitis infection among drug addicts . Fed Proc . 1984;43:603. 12. Rizzetto M, Canese MG, Arico S, et al. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and serum of HBsAg carriers . Gut . 1977;18:997-1003.Crossref 13. Ponzetto A, Hoofnagle JH, Seeff LB. Antibody to hepatitis B virusassociated delta-agent in immune serum globulins . Gastroenterology . 1984;87:1213-1216. 14. Changing patterns of groups at high risk for hepatitis B in the United States . MMWR . 1988;37:429-437. 15. Delta hepatitis-Massachusetts . MMWR . 1984;33:493-494. 16. Fulminant hepatitis B among parenteral drug abusers-Kentucky, California . MMWR . 1984;33:70-77. 17. Hepatitis B-New Bern, North Carolina . MMWR . 1979;28:373-374. 18. Immunization Practices Advisory Committee. Update on hepatitis B prevention . MMWR . 1987;36:353-366. 19. DeCock KM, Govindarajan S, Chin KP, Redeker AG. Delta hepatitis in the Los Angeles area: a report of 126 cases . Ann Intern Med . 1986;105:108-114.Crossref 20. Solomon RE, Kaslow RA, Phair, et al. Human immunodeficiency virus and hepatitis delta virus in homosexual men: a study of four cohorts . Ann Intern Med . 1988;108:51-54.Crossref 21. Hoofnagle JH, Dusheiko GM, Seeff LB, Jones EA, Waggoner JG, Bales ZB. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis . Ann Intern Med . 1981;94:744-748.Crossref 22. Smedile A, Farci P, Verme G, et al. Influence of delta infection on severity of hepatitis B . Lancet . 1982;2:945-947.Crossref 23. Rabin BS, D'Amanda C. Immunoglobulin alterations associated with heroin addiction . Clin Exp Immunol . 1973;14:359-363. 24. Brown SM, Stimmel B, Taub RN, Kochwa S, Rosenfield RE. Immunologic dysfunction in heroin addicts . Arch Intern Med . 1974;134:1001-1006.Crossref 25. Foutch PG, Carey WD, Tabor E, et al. Concomitant hepatitis B surface antigen and antibody in thirteen patients . Ann Intern Med . 1983;99:460-463.Crossref 26. Shiels MT, Taswell HF, Czaja AJ, Nelson C, Swenke P. Frequency and significance of concurrent hepatitis B surface antigen and antibody in acute and chronic hepatitis B . Gastroenterology . 1987;93:675-680. 27. Tsang TK, Blei AT, O'Reilly DJ, Decker R. Clinical significance of concurrent hepatitis B surface antigen and antibody positivity . Dig Dis Sci . 1986;31:620-624.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

The Association of Hepatitis Delta Virus and Hepatitis B Virus in Parenteral Drug Abusers: 1971 to 1972 and 1986 to 1987

Download PDF
4 pages

Loading next page...
 
/lp/american-medical-association/the-association-of-hepatitis-delta-virus-and-hepatitis-b-virus-in-9jxjNb6EiC

References (24)

Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1990.00390140087019
Publisher site
See Article on Publisher Site

Abstract

Abstract • From 1971 to 1972 (N=105) and 1986 to 1987 (N=160), parenteral drug abusers seropositive for hepatitis B virus (HBV) markers were screened for antibodies to the hepatitis delta virus (anti-HD). In both time frames anti-HD was independently associated with the hepatitis B surface antigen. It was observed that 31% of those positive for hepatitis B surface antigen from the early sample and 20% of those from the latter sample had detectable anti-HD, as opposed to 10% and 7%, respectively, of those negative for hepatitis B surface antigen. Anti-HD seropositivity was unrelated to gender and ethnicity, and in the 1971 and 1972 nationwide sample, its presence was unrelated to geographic location. The probability of manifesting anti-HD increased with the more HBV markers detected, particularly the number of different HBV antibody markers. We conclude that anti-HD was widespread in parenteral drug abusers at least as early as 1971, and that its expression was associated with hepatitis B surface antigen and the intensity of the immune response to HBV as evidenced by the number of different circulating HBV antibodies. (Arch Intern Med. 1990;150:365-368) References 1. Iwarson SA. Chronic hepatitis B . In: Gerety RJ, ed. Hepatitis B . Orlando, Fla: Academic Press Inc; 1985:129. 2. Junge V, Deinhardt F. The acute manifestations of hepatitis B virus infection . In: Gerety RJ, ed. Hepatitis B . Orlando, Fla: Academic Press Inc; 1985:103. 3. Jacobson IM, Dienstag JL, Werner BG, Brettler DB, Levine PH, Mushahwar IK. Epidemiology and clinical impact of hepatitis D virus (delta) infection . Hepatology . 1985;5:188-191.Crossref 4. Ponzetto A, Seeff LB, Buskell-Bales Z, et al. Hepatitis B markers in United States drug addicts with special emphasis on the delta hepatitis virus . Hepatology . 1984;4:1111-1115.Crossref 5. Nishioka NS, Dienstag JL. Delta hepatitis: a new scourge? N Engl J Med . 1985;312:1515-1516.Crossref 6. Kunches MM, Craven DE, Werner BG. Seroprevalence of hepatitis B virus and delta agent in parenteral drug abusers: immunogenecity of hepatitis B vaccine . Am J Med . 1986;81:591-595.Crossref 7. Rodriguez M, Perez R, Sala P, Rodrigo L. Hepatitis B markers in United States drug addicts with special emphasis on the delta hepatitis virus . Hepatology . 1986;6:155.Crossref 8. Seeff LB, Ponzetto A, Hoofnagle JH, Gerin JL. Hepatitis B markers in United States addicts with special emphasis on the delta hepatitis virus . Hepatology . 1986;6:155-156.Crossref 9. Lange WR, Snyder FR, Lozovsky D, Kaistha V, Kaczaniuk MA, Jaffe JH. HIV infection in Baltimore: antibody seroprevalence rates among parenteral drug abusers and prostitutes . Md Med J . 1987;36:757-761. 10. Lange WR, Snyder FR, Lozovsky D, et al. Geographic distribution of human immunodeficiency virus markers in parenteral drug abusers . Am J Public Health . 1988;78:443-446.Crossref 11. Moore JD. Serologic markers of hepatitis infection among drug addicts . Fed Proc . 1984;43:603. 12. Rizzetto M, Canese MG, Arico S, et al. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and serum of HBsAg carriers . Gut . 1977;18:997-1003.Crossref 13. Ponzetto A, Hoofnagle JH, Seeff LB. Antibody to hepatitis B virusassociated delta-agent in immune serum globulins . Gastroenterology . 1984;87:1213-1216. 14. Changing patterns of groups at high risk for hepatitis B in the United States . MMWR . 1988;37:429-437. 15. Delta hepatitis-Massachusetts . MMWR . 1984;33:493-494. 16. Fulminant hepatitis B among parenteral drug abusers-Kentucky, California . MMWR . 1984;33:70-77. 17. Hepatitis B-New Bern, North Carolina . MMWR . 1979;28:373-374. 18. Immunization Practices Advisory Committee. Update on hepatitis B prevention . MMWR . 1987;36:353-366. 19. DeCock KM, Govindarajan S, Chin KP, Redeker AG. Delta hepatitis in the Los Angeles area: a report of 126 cases . Ann Intern Med . 1986;105:108-114.Crossref 20. Solomon RE, Kaslow RA, Phair, et al. Human immunodeficiency virus and hepatitis delta virus in homosexual men: a study of four cohorts . Ann Intern Med . 1988;108:51-54.Crossref 21. Hoofnagle JH, Dusheiko GM, Seeff LB, Jones EA, Waggoner JG, Bales ZB. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis . Ann Intern Med . 1981;94:744-748.Crossref 22. Smedile A, Farci P, Verme G, et al. Influence of delta infection on severity of hepatitis B . Lancet . 1982;2:945-947.Crossref 23. Rabin BS, D'Amanda C. Immunoglobulin alterations associated with heroin addiction . Clin Exp Immunol . 1973;14:359-363. 24. Brown SM, Stimmel B, Taub RN, Kochwa S, Rosenfield RE. Immunologic dysfunction in heroin addicts . Arch Intern Med . 1974;134:1001-1006.Crossref 25. Foutch PG, Carey WD, Tabor E, et al. Concomitant hepatitis B surface antigen and antibody in thirteen patients . Ann Intern Med . 1983;99:460-463.Crossref 26. Shiels MT, Taswell HF, Czaja AJ, Nelson C, Swenke P. Frequency and significance of concurrent hepatitis B surface antigen and antibody in acute and chronic hepatitis B . Gastroenterology . 1987;93:675-680. 27. Tsang TK, Blei AT, O'Reilly DJ, Decker R. Clinical significance of concurrent hepatitis B surface antigen and antibody positivity . Dig Dis Sci . 1986;31:620-624.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Feb 1, 1990

There are no references for this article.