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Protein Intake and Kidney Function in Humans: Its Effect on 'Normal Aging'

Protein Intake and Kidney Function in Humans: Its Effect on 'Normal Aging' Abstract • The effect of dietary protein on kidney function expressed by creatinine clearance was studied in healthy subjects following a "normal" unrestricted protein diet and compared with a group of vegetarians maintained on a long-term low-protein diet. Both groups had similar kidney function and displayed the same rate of progressive deterioration in renal function with age. These results suggest that, in contrast with the important therapeutic effect of low-protein intake on the progressive deterioration of kidney function in diseased kidneys, such a diet does not significantly affect kidney function with "normal aging" in healthy subjects. (Arch Intern Med 1989;149:211-212) References 1. Rosman JB, Meyer S, Sluiter WJ, et al: Prospective randomized trial of early dietary protein restriction in chronic renal failure . Lancet 1984;2:1291-1296.Crossref 2. Alvestrand A, Ahlbey M, Beystrom J: Retardation of the progression of renal insufficiency in patients treated with low-protein diets . Kidney Int 1983;24( (suppl 16) ):268-272.Crossref 3. Gretz N, Korb E, Strauch M: Low-protein diet supplemented by keto acids in chronic renal failure: A prospective controlled study . Kidney Int 1983;24( (suppl 16) ):263-267. 4. Maschio G, Oldrizzi F, Tessitore N, et al: Early dietary protein and phosphorous restriction is effective in delaying progression of chronic renal failure . Kidney Int 1983;24( (suppl 16) ):274-277. 5. Maschio G, Oldrizzi F, Tessitore N, et al: Effects of dietary protein and phosphorous restriction on the progression of early renal failure . Kidney Int 1982;22:271-276.Crossref 6. Barsotti G, Guiducci A, Ciardella F, et al: Effects on renal function of a low nitrogen diet supplemented with essential amino acids and ketoanalogues and of hemodialysis and free protein supply in patients with chronic renal failure . Nephron 1981;27:113-117.Crossref 7. Mitch WF, Walser M: The effect of nutritional therapy on progression of chronic renal failure: Quantitative assessment , abstracted. Clin Res 1976;24:407. 8. Levin DM, Cade R: Metabolic effects of dietary protein in chronic renal failure . Ann Intern Med 1965;4:642-653.Crossref 9. Mackay EM, Mackay LL, Addis T: Factors which determine renal weight: V. The protein intake . Am J Physiol 1928;86:642-653. 10. Schoolwerth AC, Sandler RS, Hoffman PM, et al: Effects of nephron reduction and dietary protein content on renal ammoniagenesis in rats . Kidney Int 1975;7:397-404.Crossref 11. Bosh Jp, Saccaggi A, Luer A, et al: Renal function reserve in humans, effect of protein intake on glomerular filtration rate . Am J Med 1975;75:943-950.Crossref 12. Bosh JP, Luer A, Glabman S: Short-term protein loading in assessment of patients with renal disease . Am J Med 1984;77:873-879.Crossref 13. Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease: The role of hemodynamically mediated glomerular sclerosis in aging, renal ablation and intrinsic renal disease . N Engl J Med 1982;307:652-659.Crossref 14. Cockroft D, Gault M: Prediction of creatinine clearance from serum creatinine . Nephron 1976;16:31-41.Crossref 15. Denham MJ, Hodkinson HM, Fisher M: Glomerular filtration rate in sick elderly in-patients . Age Ageing 1976;4:32-36.Crossref 16. Cochran ST, Pagani JJ, Barbaric ZL: Nephromegaly in hyperalimentation . Radiology 1979;130:603-606.Crossref 17. Robertson JL, Goldschmidt M, Kronfeld DS, et al: Long-term renal responses to high dietary protein in dogs with 75% nephrectomy . Kidney Int 1986;29:511-519.Crossref 18. Chan AYM, Cheng ML, Keil LC, et al: Function response of diseased glomeruli to a large protein-meal . J Clin Invest 1988;81:245-254.Crossref 19. Fine LG: Preventing the progression of human renal disease: Have rational therapeutic principles emerged? Kidney Int 1988;33:116-128.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Protein Intake and Kidney Function in Humans: Its Effect on 'Normal Aging'

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1989.00390010173026
Publisher site
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Abstract

Abstract • The effect of dietary protein on kidney function expressed by creatinine clearance was studied in healthy subjects following a "normal" unrestricted protein diet and compared with a group of vegetarians maintained on a long-term low-protein diet. Both groups had similar kidney function and displayed the same rate of progressive deterioration in renal function with age. These results suggest that, in contrast with the important therapeutic effect of low-protein intake on the progressive deterioration of kidney function in diseased kidneys, such a diet does not significantly affect kidney function with "normal aging" in healthy subjects. (Arch Intern Med 1989;149:211-212) References 1. Rosman JB, Meyer S, Sluiter WJ, et al: Prospective randomized trial of early dietary protein restriction in chronic renal failure . Lancet 1984;2:1291-1296.Crossref 2. Alvestrand A, Ahlbey M, Beystrom J: Retardation of the progression of renal insufficiency in patients treated with low-protein diets . Kidney Int 1983;24( (suppl 16) ):268-272.Crossref 3. Gretz N, Korb E, Strauch M: Low-protein diet supplemented by keto acids in chronic renal failure: A prospective controlled study . Kidney Int 1983;24( (suppl 16) ):263-267. 4. Maschio G, Oldrizzi F, Tessitore N, et al: Early dietary protein and phosphorous restriction is effective in delaying progression of chronic renal failure . Kidney Int 1983;24( (suppl 16) ):274-277. 5. Maschio G, Oldrizzi F, Tessitore N, et al: Effects of dietary protein and phosphorous restriction on the progression of early renal failure . Kidney Int 1982;22:271-276.Crossref 6. Barsotti G, Guiducci A, Ciardella F, et al: Effects on renal function of a low nitrogen diet supplemented with essential amino acids and ketoanalogues and of hemodialysis and free protein supply in patients with chronic renal failure . Nephron 1981;27:113-117.Crossref 7. Mitch WF, Walser M: The effect of nutritional therapy on progression of chronic renal failure: Quantitative assessment , abstracted. Clin Res 1976;24:407. 8. Levin DM, Cade R: Metabolic effects of dietary protein in chronic renal failure . Ann Intern Med 1965;4:642-653.Crossref 9. Mackay EM, Mackay LL, Addis T: Factors which determine renal weight: V. The protein intake . Am J Physiol 1928;86:642-653. 10. Schoolwerth AC, Sandler RS, Hoffman PM, et al: Effects of nephron reduction and dietary protein content on renal ammoniagenesis in rats . Kidney Int 1975;7:397-404.Crossref 11. Bosh Jp, Saccaggi A, Luer A, et al: Renal function reserve in humans, effect of protein intake on glomerular filtration rate . Am J Med 1975;75:943-950.Crossref 12. Bosh JP, Luer A, Glabman S: Short-term protein loading in assessment of patients with renal disease . Am J Med 1984;77:873-879.Crossref 13. Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease: The role of hemodynamically mediated glomerular sclerosis in aging, renal ablation and intrinsic renal disease . N Engl J Med 1982;307:652-659.Crossref 14. Cockroft D, Gault M: Prediction of creatinine clearance from serum creatinine . Nephron 1976;16:31-41.Crossref 15. Denham MJ, Hodkinson HM, Fisher M: Glomerular filtration rate in sick elderly in-patients . Age Ageing 1976;4:32-36.Crossref 16. Cochran ST, Pagani JJ, Barbaric ZL: Nephromegaly in hyperalimentation . Radiology 1979;130:603-606.Crossref 17. Robertson JL, Goldschmidt M, Kronfeld DS, et al: Long-term renal responses to high dietary protein in dogs with 75% nephrectomy . Kidney Int 1986;29:511-519.Crossref 18. Chan AYM, Cheng ML, Keil LC, et al: Function response of diseased glomeruli to a large protein-meal . J Clin Invest 1988;81:245-254.Crossref 19. Fine LG: Preventing the progression of human renal disease: Have rational therapeutic principles emerged? Kidney Int 1988;33:116-128.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Jan 1, 1989

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