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Elevation of Anti-DNA Antibody Titer During Thyrotoxic Phase of Silent Thyroiditis

Elevation of Anti-DNA Antibody Titer During Thyrotoxic Phase of Silent Thyroiditis Abstract • The elevation of anti-DNA antibody titers was observed in two cases of silent thyroiditis; the levels reverted to normal as thyrotoxicosis improved. Biopsy specimens of the thyroid gland revealed chronic lymphocytic thyroiditis. The elevation of anti-DNA antibody titers during the thyrotoxic phase of silent thyroiditis, to our knowledge, has not been reported. In one case, antinuclear antibody testing was also positive during the thyrotoxic phase and became negative in the euthyroid state. These observations provide further support for autoimmunity in silent thyroiditis. (Arch Intern Med 1986;146:1623-1624) References 1. Nikolai TF, Brosseau J, Kettrick A, et al: Lymphocytic thyroiditis with spontaneously resolving hyperthyroidism (silent thyroiditis). Arch Intern Med 1980;140:478-482.Crossref 2. Levine SN: Current concepts of thyroiditis. Arch Intern Med 1983;143: 1952-1956.Crossref 3. Dorfman SG, Cooperman MT, Nelson RL, et al: Painless thyroiditis and transient hyperthyroidism without goiter. Ann Intern Med 1977;86: 24-28.Crossref 4. Gluck FB, Nusynowitz ML, Plymate 0: Chronic lymphocytic thyroiditis, thyrotoxicosis and low radioiodine uptake: Report of four cases. N Engl J Med 1975;293:624-628.Crossref 5. Fatourechi V, McConahey M, Woolner LB: Hyperthyroidism associated with histologic Hashimoto's thyroiditis. Mayo Clin Proc 1971;46:682-689. 6. Amino N, Mori H, Iwatani Y, et al: High prevalence of transient post-partum thyrotoxicosis and hypothyroidism. N Engl J Med 1982;306: 849-852.Crossref 7. Jansson R, Säfweberg J, Dahlberg PA: Influence of the HLA-DR4 antigen and iodine status on the development of autoimmune post-partum thyroiditis. J Clin Endocrinol Metab 1985;60:168-173.Crossref 8. Woolf PD: Transient painless thyroiditis with hyperthyroidism: A variant of lymphocytic thyroiditis? Endocr Rev 1980;1:411-420.Crossref 9. Amino N, Miyai K, Kuro K, et al: Transient post-partum hypothyroidism: Fourteen cases with autoimmune thyroiditis. Ann Intern Med 1977;87:155-159.Crossref 10. Fein HG, Goldman JM, Weintraub BD: Postpartum lymphocytic thyroiditis in American women: A spectrum of thyroid dysfunction. Am J Obstet Gynecol 1980;138:504-510. 11. Maruyama H, Kato M, Mizuno O, et al: Transient thyrotoxicosis occurred after cessation of steroid therapy in a patient with autoimmune thyroiditis and rheumatoid arthritis. Endocrinol Jpn 1982;29:583-588.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Elevation of Anti-DNA Antibody Titer During Thyrotoxic Phase of Silent Thyroiditis

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1986.00360200203033
Publisher site
See Article on Publisher Site

Abstract

Abstract • The elevation of anti-DNA antibody titers was observed in two cases of silent thyroiditis; the levels reverted to normal as thyrotoxicosis improved. Biopsy specimens of the thyroid gland revealed chronic lymphocytic thyroiditis. The elevation of anti-DNA antibody titers during the thyrotoxic phase of silent thyroiditis, to our knowledge, has not been reported. In one case, antinuclear antibody testing was also positive during the thyrotoxic phase and became negative in the euthyroid state. These observations provide further support for autoimmunity in silent thyroiditis. (Arch Intern Med 1986;146:1623-1624) References 1. Nikolai TF, Brosseau J, Kettrick A, et al: Lymphocytic thyroiditis with spontaneously resolving hyperthyroidism (silent thyroiditis). Arch Intern Med 1980;140:478-482.Crossref 2. Levine SN: Current concepts of thyroiditis. Arch Intern Med 1983;143: 1952-1956.Crossref 3. Dorfman SG, Cooperman MT, Nelson RL, et al: Painless thyroiditis and transient hyperthyroidism without goiter. Ann Intern Med 1977;86: 24-28.Crossref 4. Gluck FB, Nusynowitz ML, Plymate 0: Chronic lymphocytic thyroiditis, thyrotoxicosis and low radioiodine uptake: Report of four cases. N Engl J Med 1975;293:624-628.Crossref 5. Fatourechi V, McConahey M, Woolner LB: Hyperthyroidism associated with histologic Hashimoto's thyroiditis. Mayo Clin Proc 1971;46:682-689. 6. Amino N, Mori H, Iwatani Y, et al: High prevalence of transient post-partum thyrotoxicosis and hypothyroidism. N Engl J Med 1982;306: 849-852.Crossref 7. Jansson R, Säfweberg J, Dahlberg PA: Influence of the HLA-DR4 antigen and iodine status on the development of autoimmune post-partum thyroiditis. J Clin Endocrinol Metab 1985;60:168-173.Crossref 8. Woolf PD: Transient painless thyroiditis with hyperthyroidism: A variant of lymphocytic thyroiditis? Endocr Rev 1980;1:411-420.Crossref 9. Amino N, Miyai K, Kuro K, et al: Transient post-partum hypothyroidism: Fourteen cases with autoimmune thyroiditis. Ann Intern Med 1977;87:155-159.Crossref 10. Fein HG, Goldman JM, Weintraub BD: Postpartum lymphocytic thyroiditis in American women: A spectrum of thyroid dysfunction. Am J Obstet Gynecol 1980;138:504-510. 11. Maruyama H, Kato M, Mizuno O, et al: Transient thyrotoxicosis occurred after cessation of steroid therapy in a patient with autoimmune thyroiditis and rheumatoid arthritis. Endocrinol Jpn 1982;29:583-588.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1986

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