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Prevention of Amphotericin B—Induced Rigors by Dantrolene

Prevention of Amphotericin B—Induced Rigors by Dantrolene Abstract • Three patients had severe amphotericin B—induced rigors refractory to conventional prophylactic measures. Rigors improved or disappeared when dantrolene sodium was given prophylactically or during an episode. These observations suggest that dantrolene is useful as an alternative or adjuvant agent for severe rigors associated with amphotericin B infusion. (Arch Intern Med 1986;146:1587-1588) References 1. Maddux MS, Barriere SL: A review of complications of amphotericin-B therapy: Recommendations for prevention and management. Drug Intell Clin Pharm 1980;14:177-181. 2. Bennett JE: Treatment of cryptococcal, candidal, and coccidioidal meningitis , in Remington JS (ed): Current Clinical Topics in Infectious Diseases . New York, McGraw-Hill International Book Co, 1981, vol 5, pp 54-68. 3. Burks C, Aisner J, Fortner CL, et al: Meperidine for the treatment of shaking chills and fever. JAMA 1980;140:483-484. 4. Tynes BS, Utz JP, Bennett JE, et al: Reducing amphotericin-B reactions. Am Rev Respir Dis 1963;87:264-268. 5. VanWinkle WB: Calcium release from skeletal muscle sarcoplasmic reticulum: Site of action of dantrolene sodium. Science 1976;193:1130-1131.Crossref 6. Pinder RM, Brogden RN, Speight TM, et al: Dantrolene sodium: A review of its pharmacologic properties and therapeutic efficacy in spasticity. Drugs 1977;13:3-23.Crossref 7. Tidyman M, Prichard JG, Deamer RL, et al: Adjunctive use of dantrolene in severe tetanus. Anesth Analg 1985;64:538-540.Crossref 8. May DC, Morris SW, Stewart RM, et al: Neuroleptic malignant syndrome: Response to dantrolene sodium. Ann Intern Med 1983;98:183-184.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Prevention of Amphotericin B—Induced Rigors by Dantrolene

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1986.00360200157025
Publisher site
See Article on Publisher Site

Abstract

Abstract • Three patients had severe amphotericin B—induced rigors refractory to conventional prophylactic measures. Rigors improved or disappeared when dantrolene sodium was given prophylactically or during an episode. These observations suggest that dantrolene is useful as an alternative or adjuvant agent for severe rigors associated with amphotericin B infusion. (Arch Intern Med 1986;146:1587-1588) References 1. Maddux MS, Barriere SL: A review of complications of amphotericin-B therapy: Recommendations for prevention and management. Drug Intell Clin Pharm 1980;14:177-181. 2. Bennett JE: Treatment of cryptococcal, candidal, and coccidioidal meningitis , in Remington JS (ed): Current Clinical Topics in Infectious Diseases . New York, McGraw-Hill International Book Co, 1981, vol 5, pp 54-68. 3. Burks C, Aisner J, Fortner CL, et al: Meperidine for the treatment of shaking chills and fever. JAMA 1980;140:483-484. 4. Tynes BS, Utz JP, Bennett JE, et al: Reducing amphotericin-B reactions. Am Rev Respir Dis 1963;87:264-268. 5. VanWinkle WB: Calcium release from skeletal muscle sarcoplasmic reticulum: Site of action of dantrolene sodium. Science 1976;193:1130-1131.Crossref 6. Pinder RM, Brogden RN, Speight TM, et al: Dantrolene sodium: A review of its pharmacologic properties and therapeutic efficacy in spasticity. Drugs 1977;13:3-23.Crossref 7. Tidyman M, Prichard JG, Deamer RL, et al: Adjunctive use of dantrolene in severe tetanus. Anesth Analg 1985;64:538-540.Crossref 8. May DC, Morris SW, Stewart RM, et al: Neuroleptic malignant syndrome: Response to dantrolene sodium. Ann Intern Med 1983;98:183-184.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Aug 1, 1986

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