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F. Rosenbloom, J. Seegmiller (1964)
AN ENZYMATIC SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF OROTIC ACID.The Journal of laboratory and clinical medicine, 63
Seegmiller JE Boss GR (1979)
Hyperuricemia and gout.N Engl J Med, 300
M. Pera, H. Harder (1977)
Analysis for platinum in biological material by flameless atomic absorption spectrometry.Clinical chemistry, 23 7
Benjamin RS Stewart DJ (1982)
Human tissue distribution of platinum after cis-diammunedichloroplatinum.Cancer Chemother Pharmacol, 10
Weiner Mw, C. Jacobs (1983)
Mechanism of cisplatin nephrotoxicity.Federation proceedings, 42 13
J. Blachley, J. Hill (1981)
Renal and electrolyte disturbances associated with cisplatin.Annals of internal medicine, 95 5
Abstract • Hyperuricemia associated with cisplatin therapy is considered to be a consequence of cisplatin-induced nephrotoxic reactions. We correlated changes in serum uric acid levels in patients with malignant neoplasms with tissue levels of platinum and the total dose of cisplatin. In 15 patients, the serum uric acid level increased from 6.1± 1.0 mg/dL to 8.3 ±1.3 mg/dL during the time they were receiving cisplatin therapy. The change in uric acid level from baseline to peak correlated with both the total dose of cisplatin and the liver platinum concentration. There was no correlation with platinum concentration in the renal cortex and medulla. (Arch Intern Med 1985;145:2013-2014) References 1. Blachley JD, Hill JB: Renal and electrolyte disturbances associated with cisplatin. Ann Intern Med 1981;95:628-632.Crossref 2. Weiner WM, Jacobs C: Mechanisms of cisplatin nephrotoxicity. Fed Proc 1983;42:2974-2978. 3. Boss GR, Seegmiller JE: Hyperuricemia and gout. N Engl J Med 1979;300:1459-1468.Crossref 4. Liddle L, Seegmiller JE, Laster L: The enzymatic spectrophotometric method for determination of uric acid. J Lab Clin Med 1959;54:903-913. 5. Pera MJ, Harder HC: Analysis for platinum in biological material by flameless atomic absorption spectrophotometry. Clin Chem 1977;23:1245-1251. 6. Stewart DJ, Benjamin RS, Lean M, et al: Human tissue distribution of platinum after cis-diammunedichloroplatinum. Cancer Chemother Pharmacol 1982;10:51-54.
Archives of Internal Medicine – American Medical Association
Published: Nov 1, 1985
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