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Increase in Serum Uric Acid Level Associated With Cisplatin Therapy: Correlation With Liver but Not Kidney Platinum Concentrations

Increase in Serum Uric Acid Level Associated With Cisplatin Therapy: Correlation With Liver but... Abstract • Hyperuricemia associated with cisplatin therapy is considered to be a consequence of cisplatin-induced nephrotoxic reactions. We correlated changes in serum uric acid levels in patients with malignant neoplasms with tissue levels of platinum and the total dose of cisplatin. In 15 patients, the serum uric acid level increased from 6.1± 1.0 mg/dL to 8.3 ±1.3 mg/dL during the time they were receiving cisplatin therapy. The change in uric acid level from baseline to peak correlated with both the total dose of cisplatin and the liver platinum concentration. There was no correlation with platinum concentration in the renal cortex and medulla. (Arch Intern Med 1985;145:2013-2014) References 1. Blachley JD, Hill JB: Renal and electrolyte disturbances associated with cisplatin. Ann Intern Med 1981;95:628-632.Crossref 2. Weiner WM, Jacobs C: Mechanisms of cisplatin nephrotoxicity. Fed Proc 1983;42:2974-2978. 3. Boss GR, Seegmiller JE: Hyperuricemia and gout. N Engl J Med 1979;300:1459-1468.Crossref 4. Liddle L, Seegmiller JE, Laster L: The enzymatic spectrophotometric method for determination of uric acid. J Lab Clin Med 1959;54:903-913. 5. Pera MJ, Harder HC: Analysis for platinum in biological material by flameless atomic absorption spectrophotometry. Clin Chem 1977;23:1245-1251. 6. Stewart DJ, Benjamin RS, Lean M, et al: Human tissue distribution of platinum after cis-diammunedichloroplatinum. Cancer Chemother Pharmacol 1982;10:51-54. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Increase in Serum Uric Acid Level Associated With Cisplatin Therapy: Correlation With Liver but Not Kidney Platinum Concentrations

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1985.00360110083019
Publisher site
See Article on Publisher Site

Abstract

Abstract • Hyperuricemia associated with cisplatin therapy is considered to be a consequence of cisplatin-induced nephrotoxic reactions. We correlated changes in serum uric acid levels in patients with malignant neoplasms with tissue levels of platinum and the total dose of cisplatin. In 15 patients, the serum uric acid level increased from 6.1± 1.0 mg/dL to 8.3 ±1.3 mg/dL during the time they were receiving cisplatin therapy. The change in uric acid level from baseline to peak correlated with both the total dose of cisplatin and the liver platinum concentration. There was no correlation with platinum concentration in the renal cortex and medulla. (Arch Intern Med 1985;145:2013-2014) References 1. Blachley JD, Hill JB: Renal and electrolyte disturbances associated with cisplatin. Ann Intern Med 1981;95:628-632.Crossref 2. Weiner WM, Jacobs C: Mechanisms of cisplatin nephrotoxicity. Fed Proc 1983;42:2974-2978. 3. Boss GR, Seegmiller JE: Hyperuricemia and gout. N Engl J Med 1979;300:1459-1468.Crossref 4. Liddle L, Seegmiller JE, Laster L: The enzymatic spectrophotometric method for determination of uric acid. J Lab Clin Med 1959;54:903-913. 5. Pera MJ, Harder HC: Analysis for platinum in biological material by flameless atomic absorption spectrophotometry. Clin Chem 1977;23:1245-1251. 6. Stewart DJ, Benjamin RS, Lean M, et al: Human tissue distribution of platinum after cis-diammunedichloroplatinum. Cancer Chemother Pharmacol 1982;10:51-54.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1985

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