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Neuroleptic Malignant Syndrome Complicated by Disseminated Intravascular Coagulation

Neuroleptic Malignant Syndrome Complicated by Disseminated Intravascular Coagulation Abstract • The neuroleptic malignant syndrome (NMS), clinically manifested by hyperpyrexia, mental status changes, muscular rigidity, and autonomic dysfunction, is an idiosyncratic reaction to major neuroleptic pharmacologic agents. The reported causes of morbidity and mortality include respiratory insufficiency, cardiovascular collapse, arrhythmias, and renal failure. Coagulopathy does not seem to be a prominent component of the syndrome. We observed a case of NMS in which disseminated intravascular coagulation was a prominent feature. (Arch Intern Med 1984;144:1296-1297) References 1. Delay J, Deniker P: Drug-induced extrapyramidal syndromes , in Vinkin PJ, Bruyn GW (eds): Handbook of Clinical Neurology: Disease of the Basal Ganglia . New York, Elsevier North-Holland Inc, 1968, vol 6, pp 248-266. 2. Smego R Jr, Durack DT: The neuroleptic malignant syndrome. Arch Intern Med 1982;142:1183-1185.Crossref 3. Henderson VW, Wooten GF: Neuroleptic malignant syndrome: A pathogenic role for dopamine receptor blockade? Neurology 1981;31: 132-137.Crossref 4. Meltzer HY: Rigidity, hyperpyrexia, and coma following fluphenazine enauthate. Psychopharmacologia . 1973;29:337-346.Crossref 5. McAllister RG Jr: Fever, tachycardia, and hypertension with acute catatonic schizophrenia. Arch Intern Med 1978;138:1154-1156.Crossref 6. Eiser AR, Neff MS, Slifkin RF: Acute myoglobinuric renal failure: A consequence of the neuroleptic malignant syndrome. Arch Intern Med 1982;142:601-603.Crossref 7. Mahutte CK, Nakasato SK, Light RW: Haloperidol and sudden death due to pulmonary edema. Arch Intern Med 1982;142:1951-1952.Crossref 8. Bell WR: Disseminated intravascular coagulation. Johns Hopkins Med J 1980;146:289-299. 9. Frank LI, Admire RC: Rhabdomyalysis. Urol Clin North Am 1982;9: 267-274. 10. Hart GR, Anderson RJ, Crumpler CP, et al: Epidemic classical heat stroke: Clinical characteristics and course of 28 patients. Medicine 1982;61:189-197.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Neuroleptic Malignant Syndrome Complicated by Disseminated Intravascular Coagulation

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1984.00350180244037
Publisher site
See Article on Publisher Site

Abstract

Abstract • The neuroleptic malignant syndrome (NMS), clinically manifested by hyperpyrexia, mental status changes, muscular rigidity, and autonomic dysfunction, is an idiosyncratic reaction to major neuroleptic pharmacologic agents. The reported causes of morbidity and mortality include respiratory insufficiency, cardiovascular collapse, arrhythmias, and renal failure. Coagulopathy does not seem to be a prominent component of the syndrome. We observed a case of NMS in which disseminated intravascular coagulation was a prominent feature. (Arch Intern Med 1984;144:1296-1297) References 1. Delay J, Deniker P: Drug-induced extrapyramidal syndromes , in Vinkin PJ, Bruyn GW (eds): Handbook of Clinical Neurology: Disease of the Basal Ganglia . New York, Elsevier North-Holland Inc, 1968, vol 6, pp 248-266. 2. Smego R Jr, Durack DT: The neuroleptic malignant syndrome. Arch Intern Med 1982;142:1183-1185.Crossref 3. Henderson VW, Wooten GF: Neuroleptic malignant syndrome: A pathogenic role for dopamine receptor blockade? Neurology 1981;31: 132-137.Crossref 4. Meltzer HY: Rigidity, hyperpyrexia, and coma following fluphenazine enauthate. Psychopharmacologia . 1973;29:337-346.Crossref 5. McAllister RG Jr: Fever, tachycardia, and hypertension with acute catatonic schizophrenia. Arch Intern Med 1978;138:1154-1156.Crossref 6. Eiser AR, Neff MS, Slifkin RF: Acute myoglobinuric renal failure: A consequence of the neuroleptic malignant syndrome. Arch Intern Med 1982;142:601-603.Crossref 7. Mahutte CK, Nakasato SK, Light RW: Haloperidol and sudden death due to pulmonary edema. Arch Intern Med 1982;142:1951-1952.Crossref 8. Bell WR: Disseminated intravascular coagulation. Johns Hopkins Med J 1980;146:289-299. 9. Frank LI, Admire RC: Rhabdomyalysis. Urol Clin North Am 1982;9: 267-274. 10. Hart GR, Anderson RJ, Crumpler CP, et al: Epidemic classical heat stroke: Clinical characteristics and course of 28 patients. Medicine 1982;61:189-197.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Jun 1, 1984

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