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Evaluation of Bismuth Subsalicylate in Relieving Symptoms of Indigestion

Evaluation of Bismuth Subsalicylate in Relieving Symptoms of Indigestion Abstract • The efficacy of bismuth subsalicylate in relieving the symptoms of indigestion was evaluated in a randomized, placebo-controlled, double-blind, cross-over study in 48 adults. Each patient was treated for six episodes of indigestion, three episodes with bismuth subsalicylate and three with placebo. Volunteers took 30 ml when the symptoms first occurred and repeated the dose every half hour, as needed, for eight doses. The volunteers rated the severity of each symptom 15 and 30 minutes after each dose. Overall relief was achieved faster and in a higher proportion of cases in bismuth subsalicylate-treated episodes than in placebo-treated episodes. Bismuth subsalicylate provided greater and faster relief than placebo for nausea, sense of fullness, heartburn, feeling of abdominal distention, and flatulence, but not for upper abdominal pain. (Arch Intern Med 1984;144:269-272) References 1. Dupont HL, Sullivan P, Pickering LK, et al: Symptomatic treatment of diarrhea with bismuth subsalicylate among students attending a Mexican university. Gastroenterology 1977;73:715-718. 2. Dupont HL, Sullivan P, Evans DG, et al: Prevention of traveler's diarrhea (emporiatric enteritis). Prophylactic administration of subsalicylate bismuth. JAMA 1980;243:237-241.Crossref 3. Ericsson CD, Evans DG, Dupont HL, et al: Neutralization of cholera and E coli enterotoxin by Pepto-Bismol (PB). Abstracts of the 16th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Oct 27-29, 1976. 4. Stek M: Traveler's diarrhea in the Mediterranean basin. Milit Med 1980;145:628-629. 5. Steinhoff MC, Douglas RG, Greenburg HB, et al: Bismuth subsalicylate therapy of viral gastroenteritis. Gastroenterology 1980;78:1495-1499. 6. Holvey DN (ed): The Merck Manual of Diagnosis and Therapy , ed 12. Rahway, NJ, Merck Sharp & Dohme Research Laboratories, 1972, p 679. 7. Goldenberg MM, Honkomp LJ, Davis CS: Antinauseant and antiemetic properties of bismuth subsalicylate in dogs and humans. J Pharm Sci 1976;65:1398-1400.Crossref 8. Berkowitz JM, Garner LH, Felarca AB: Bismuth subsalicylate in excessive alcohol/food intake. Dig Dis Sci , in press. 9. Weiss G, Serfontein WJ: The efficacy of a bismuth-protein-complex compound in the treatment of gastric and duodenal ulcers. S Afr Med J 1971;45:467-470. 10. Moshal MG: A double-blind gastroscopic study of a bismuth-peptide complex in gastric ulceration. S Afr Med J 1974;48:1610-1611. 11. Lanza FL: An endoscopic evaluation of gastric ulcer treated with a mixture containing bismuth ammonium citrate. Curr Ther Res 1970;12: 779-788. 12. Goldenberg MM, Honkomp LJ, Burrous SE, et al: Protective effect of PEPTO-BISMOL Liquid on the gastric mucosa of rats. Gastroenterology 1975;69:636-640. 13. Lorber SH: Antipeptic agents, carbenoxolone, and mucosal coating agents: Status report , in Peptic Ulcer Disease: An Update. Third International Symposium on Gastroenterology, New York, March 18 to 24, 1979 . New York, Biomedical Information Corp Publications, 1979, pp 295-305. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Evaluation of Bismuth Subsalicylate in Relieving Symptoms of Indigestion

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1984.00350140069010
Publisher site
See Article on Publisher Site

Abstract

Abstract • The efficacy of bismuth subsalicylate in relieving the symptoms of indigestion was evaluated in a randomized, placebo-controlled, double-blind, cross-over study in 48 adults. Each patient was treated for six episodes of indigestion, three episodes with bismuth subsalicylate and three with placebo. Volunteers took 30 ml when the symptoms first occurred and repeated the dose every half hour, as needed, for eight doses. The volunteers rated the severity of each symptom 15 and 30 minutes after each dose. Overall relief was achieved faster and in a higher proportion of cases in bismuth subsalicylate-treated episodes than in placebo-treated episodes. Bismuth subsalicylate provided greater and faster relief than placebo for nausea, sense of fullness, heartburn, feeling of abdominal distention, and flatulence, but not for upper abdominal pain. (Arch Intern Med 1984;144:269-272) References 1. Dupont HL, Sullivan P, Pickering LK, et al: Symptomatic treatment of diarrhea with bismuth subsalicylate among students attending a Mexican university. Gastroenterology 1977;73:715-718. 2. Dupont HL, Sullivan P, Evans DG, et al: Prevention of traveler's diarrhea (emporiatric enteritis). Prophylactic administration of subsalicylate bismuth. JAMA 1980;243:237-241.Crossref 3. Ericsson CD, Evans DG, Dupont HL, et al: Neutralization of cholera and E coli enterotoxin by Pepto-Bismol (PB). Abstracts of the 16th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Oct 27-29, 1976. 4. Stek M: Traveler's diarrhea in the Mediterranean basin. Milit Med 1980;145:628-629. 5. Steinhoff MC, Douglas RG, Greenburg HB, et al: Bismuth subsalicylate therapy of viral gastroenteritis. Gastroenterology 1980;78:1495-1499. 6. Holvey DN (ed): The Merck Manual of Diagnosis and Therapy , ed 12. Rahway, NJ, Merck Sharp & Dohme Research Laboratories, 1972, p 679. 7. Goldenberg MM, Honkomp LJ, Davis CS: Antinauseant and antiemetic properties of bismuth subsalicylate in dogs and humans. J Pharm Sci 1976;65:1398-1400.Crossref 8. Berkowitz JM, Garner LH, Felarca AB: Bismuth subsalicylate in excessive alcohol/food intake. Dig Dis Sci , in press. 9. Weiss G, Serfontein WJ: The efficacy of a bismuth-protein-complex compound in the treatment of gastric and duodenal ulcers. S Afr Med J 1971;45:467-470. 10. Moshal MG: A double-blind gastroscopic study of a bismuth-peptide complex in gastric ulceration. S Afr Med J 1974;48:1610-1611. 11. Lanza FL: An endoscopic evaluation of gastric ulcer treated with a mixture containing bismuth ammonium citrate. Curr Ther Res 1970;12: 779-788. 12. Goldenberg MM, Honkomp LJ, Burrous SE, et al: Protective effect of PEPTO-BISMOL Liquid on the gastric mucosa of rats. Gastroenterology 1975;69:636-640. 13. Lorber SH: Antipeptic agents, carbenoxolone, and mucosal coating agents: Status report , in Peptic Ulcer Disease: An Update. Third International Symposium on Gastroenterology, New York, March 18 to 24, 1979 . New York, Biomedical Information Corp Publications, 1979, pp 295-305.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1984

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