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Pathogenicity of Eikenella corrodens in Humans

Pathogenicity of Eikenella corrodens in Humans Abstract • Eikenella corrodens is resident flora of the normal adult human oral cavity. Four cases of verified infection and previous case reports of infections caused by this organism were reviewed and analyzed. Rarely has this bacillus been found as the sole isolate to initiate infection in the host with normal immune status. In the immunocompromised host, this organism was observed as the sole isolate in cases of persistent empyemas and/or overwhelming pneumonias with bacteremias. The potential of the organism singly to perpetuate an established infection appears real. In the immunocompromised patients such potentials are accentuated and can result in fulminant pulmonary infections and death. The finding of E corrodens in an infection site of a compromised patient should indicate specific therapy. (Arch Intern Med 1983;143:2265-2268) References 1. Polin K, Schulman St: Eikenella corrodens osteomyelitis. Pediatrics 1982;70:462-463. 2. Goodman AD: Eikenella corrodens isolated in oral infections of dental origin. Oral Surg 1977;44:128-134.Crossref 3. Goldstein EJC, Kirby BD, Finegold SM: Isolation of Eikenella corrodens from pulmonary infections. Am Rev Respir Dis 1979;119:55-58. 4. Brooks GF, O'Donoghue JM, Rissing JP, et al: Eikenella corrodens: A newly recognized human pathogen. Medicine 1974;53:325-342.Crossref 5. Dorff GJ, Jackson LJ, Rytel MW: Infections with Eikenella corrodens: A newly recognized human pathogen. Ann Intern Med 1974;80:305-309.Crossref 6. Sinkovics JG, Plager C, Mills K: Eikenella corrodens as pathogen. Ann Intern Med 1979;90:991.Crossref 7. Bottone EJ, Kittick J Jr, Schneierson SS: Isolation of bacillus HB-1 from human clinical sources. Am J Clin Pathol 1973;59:560-566. 8. Khairat O: Bacteroides corrodens isolated from bacteremias. J Pathol Bacteriol 1967;94:29-40.Crossref 9. Khairat O: The non-aerobes of post-extraction bacteremia. J Dent Res 1966;45:1191-1197.Crossref 10. Geraci JE, Hermans PE, Washington JA II: Eikenella corrodens endocarditis: Report of cure in two cases. Mayo Clin Proc 1974;49:950-953. 11. Fainstein V, Luna MA, Bodey GP: Endocarditis due to Eikenella corrodens in a patient with acute lymphocytic leukemia. Cancer 1981;48: 40-42.Crossref 12. Marsden HB, Hyde WA: Isolation of Bacteroides corrodens from infections in children. J Clin Pathol 1971;24:117-119.Crossref 13. Rubenstein J, Lieberman FM, Gadath N: Central nervous system infections with Eikenella corrodens: Report of two cases. Pediatrics 1976;57:264-265. 14. Burdick OC, Erasmus D, Jayaram A, et al: Eikenella brain abscess. JAMA 1982;248:1972-1973.Crossref 15. Emmerson AM, Mills F: Recurrent meningitis and brain abscess caused by Eikenella corrodens. Postgrad Med J 1978;54:343-345.Crossref 16. Schwartz H, Baskin AM, Ilkin I, et al: An unusual organism causing orbital cellulitis. Br J Opthalmol 1979;63:710-712.Crossref 17. Jones LJ, Roming AD: Eikenella corrodens: A pathogen in head and neck infections. Oral Surg 1979;48:501-505.Crossref 18. Litwack K, Bouchardt K: Osteomyelitis caused by Bacteroides corrodens—like organism (HB-1). Clin Med 1973;80:21-40. 19. Zinner SH, Daly AK, McCormack WM: Isolation of Eikenella corrodens in a general hospital. Appl Microbiol 1973;25:705-708. 20. Barton LL, Anderson LE: Paronychia caused by HB-1 organisms. Pediatrics 1974;54:372-373. 21. Kaplan MJ, McCracken HG, Nelson DT: Infection in children caused by HB group of bacteria. J Pediatr 1973;82:398-403.Crossref 22. St John MA, Belda AA, Matlow A, et al: Eikenella corrodens empyema in children. Am J Dis Child 1981;135:415-417. 23. Goldstein EJC: The infection following clenched-fist injury: A new perspective. J Hand Surg 1978;3:455-457.Crossref 24. Badger SJ, Butler T, Kim CK, et al: Experimental Eikenella corrodens endocarditis in rabbits. Infect Immun 1979;23:751-757. 25. Goldstein EJC, Sutter VL, Finegold SM: Susceptibility of Eikenella corrodens to ten cephalosporins. Antimicrob Agents Chemother 1978;14: 639-641.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

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References (29)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350120055014
Publisher site
See Article on Publisher Site

Abstract

Abstract • Eikenella corrodens is resident flora of the normal adult human oral cavity. Four cases of verified infection and previous case reports of infections caused by this organism were reviewed and analyzed. Rarely has this bacillus been found as the sole isolate to initiate infection in the host with normal immune status. In the immunocompromised host, this organism was observed as the sole isolate in cases of persistent empyemas and/or overwhelming pneumonias with bacteremias. The potential of the organism singly to perpetuate an established infection appears real. In the immunocompromised patients such potentials are accentuated and can result in fulminant pulmonary infections and death. The finding of E corrodens in an infection site of a compromised patient should indicate specific therapy. (Arch Intern Med 1983;143:2265-2268) References 1. Polin K, Schulman St: Eikenella corrodens osteomyelitis. Pediatrics 1982;70:462-463. 2. Goodman AD: Eikenella corrodens isolated in oral infections of dental origin. Oral Surg 1977;44:128-134.Crossref 3. Goldstein EJC, Kirby BD, Finegold SM: Isolation of Eikenella corrodens from pulmonary infections. Am Rev Respir Dis 1979;119:55-58. 4. Brooks GF, O'Donoghue JM, Rissing JP, et al: Eikenella corrodens: A newly recognized human pathogen. Medicine 1974;53:325-342.Crossref 5. Dorff GJ, Jackson LJ, Rytel MW: Infections with Eikenella corrodens: A newly recognized human pathogen. Ann Intern Med 1974;80:305-309.Crossref 6. Sinkovics JG, Plager C, Mills K: Eikenella corrodens as pathogen. Ann Intern Med 1979;90:991.Crossref 7. Bottone EJ, Kittick J Jr, Schneierson SS: Isolation of bacillus HB-1 from human clinical sources. Am J Clin Pathol 1973;59:560-566. 8. Khairat O: Bacteroides corrodens isolated from bacteremias. J Pathol Bacteriol 1967;94:29-40.Crossref 9. Khairat O: The non-aerobes of post-extraction bacteremia. J Dent Res 1966;45:1191-1197.Crossref 10. Geraci JE, Hermans PE, Washington JA II: Eikenella corrodens endocarditis: Report of cure in two cases. Mayo Clin Proc 1974;49:950-953. 11. Fainstein V, Luna MA, Bodey GP: Endocarditis due to Eikenella corrodens in a patient with acute lymphocytic leukemia. Cancer 1981;48: 40-42.Crossref 12. Marsden HB, Hyde WA: Isolation of Bacteroides corrodens from infections in children. J Clin Pathol 1971;24:117-119.Crossref 13. Rubenstein J, Lieberman FM, Gadath N: Central nervous system infections with Eikenella corrodens: Report of two cases. Pediatrics 1976;57:264-265. 14. Burdick OC, Erasmus D, Jayaram A, et al: Eikenella brain abscess. JAMA 1982;248:1972-1973.Crossref 15. Emmerson AM, Mills F: Recurrent meningitis and brain abscess caused by Eikenella corrodens. Postgrad Med J 1978;54:343-345.Crossref 16. Schwartz H, Baskin AM, Ilkin I, et al: An unusual organism causing orbital cellulitis. Br J Opthalmol 1979;63:710-712.Crossref 17. Jones LJ, Roming AD: Eikenella corrodens: A pathogen in head and neck infections. Oral Surg 1979;48:501-505.Crossref 18. Litwack K, Bouchardt K: Osteomyelitis caused by Bacteroides corrodens—like organism (HB-1). Clin Med 1973;80:21-40. 19. Zinner SH, Daly AK, McCormack WM: Isolation of Eikenella corrodens in a general hospital. Appl Microbiol 1973;25:705-708. 20. Barton LL, Anderson LE: Paronychia caused by HB-1 organisms. Pediatrics 1974;54:372-373. 21. Kaplan MJ, McCracken HG, Nelson DT: Infection in children caused by HB group of bacteria. J Pediatr 1973;82:398-403.Crossref 22. St John MA, Belda AA, Matlow A, et al: Eikenella corrodens empyema in children. Am J Dis Child 1981;135:415-417. 23. Goldstein EJC: The infection following clenched-fist injury: A new perspective. J Hand Surg 1978;3:455-457.Crossref 24. Badger SJ, Butler T, Kim CK, et al: Experimental Eikenella corrodens endocarditis in rabbits. Infect Immun 1979;23:751-757. 25. Goldstein EJC, Sutter VL, Finegold SM: Susceptibility of Eikenella corrodens to ten cephalosporins. Antimicrob Agents Chemother 1978;14: 639-641.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1983

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