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Bacteremic Pneumonia due to Gram-negative Bacilli

Bacteremic Pneumonia due to Gram-negative Bacilli Abstract • Bacteremic pneumonia due to aerobic gram-negative bacilli was diagnosed in 27 patients during a 20-month period. The mortality was high (81.5%) among these elderly patients (mean age, 61.2 years) with serious underlying disease, in spite of amikacin sulfate therapy that was appropriate as determined by susceptibility testing. Bacteremic pneumonia accounted for 14.1% of patients with gram-negative bacteremia but was responsible for 39.4% of the deaths in the total group of 191 patients. The worsened prognosis of patients with pneumonia was unrelated to the species of infecting organisms or the underlying conditions or disease. (Arch Intern Med 1983;143:2147-2149) References 1. Heffron R: Pneumonia: With Special Reference to Pneumococcus Lobar Pneumonia. A Commonwealth Fund Book . Reprint of edition published by the Commonwealth Fund, New York, Cambridge, Mass, Harvard University Press, 1979, pp 1-17. 2. Reyes MP: The aerobic gram-negative bacillary pneumonia. Med Clin North Am 1980;142:363-383. 3. Tillotson JR, Lerner AM: Pneumonias caused by gram negative bacilli. Medicine 1966;45:65-76.Crossref 4. Kreger BE, Craven DE, McCabe WR: Gram negative bacteremia: IV. Reevaluation of clinical features and treatment of 612 patients. Am J Med 1980;68:344-355.Crossref 5. Weinstein MP, Murphy JR, Reller LB, et al: The clinical significance of positive blood cultures: A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults: II. Clinical observation with special reference to factors influencing prognosis. Rev Infect Dis 1983;5:54-70.Crossref 6. Spengler RF, Greenough III WB, Stolley PD: A descriptive study of nosocomial bacteremia at The Johns Hopkins Hospital, 1968-1974. Johns Hopkins Med J 1978;142:77-84. 7. Lennette EH, Balows A, Hauster JP, et al: Manual of Clinical Microbiology ed 3. Washington, DC, American Society of Microbiology, 1980. 8. Thornsberry C: Automation of antibiotic susceptibility testing , in Lorian V (ed): Antibiotics in Laboratory Medicine . Baltimore, Williams & Wilkens Co, 1980, pp 201-204. 9. Jonas M, Cunha BA: Bacteremic Escherichia coli pneumonia. Arch Intern Med 1982;142:2157-2159.Crossref 10. Andriole VT: Pseudomonas bacteremia: Can antibiotic therapy improve survival? J Lab Clin Med 1979;94:196-200. 11. McCabe WR, Jackson GG: Gram-negative bacteremia: II. Clinical, laboratory and therapeutic observation. Arch Intern Med 1962; 110:856-864.Crossref 12. Pennington JE: Penetration of antibiotics into respiratory secretion. Rev Infect Dis 1981;3:67-73.Crossref 13. Bodem CR, Lampton LM, Miller DD, et al: Endobronchial pH: Relevance to aminoglycoside activity in gram-negative bacillary pneumonia. Am Rev Respir Dis 1983;127:39-41. 14. Woods DE, Straus DC, Johanson WG, et al: Role of salivary protease activity in adherence of gram-negative bacilli to mammalian buccal epithelial cells in vivo. J Clin Invest 1981;68:1435-1440.Crossref 15. Lebowitz MD: Respiratory symptoms and disease related to alcohol consumption. Am Rev Respir Dis 1981;123:16-19. 16. Haley RW, Hooton TM, Culver DH, et al: Nosocomial infection in US hospitals, 1975-1976: Estimated frequency by selected characteristics of patients. Am J Med 1981;70:947-959.Crossref 17. Stevens RM, Teres D, Skillman JJ, et al: Pneumonia in an intensive care unit: A 30-month experience. Arch Intern Med 1974;134:106-111.Crossref 18. Campbell EJ, Lefrek SS: How aging affects the structure and function of the respiratory system. Geriatrics 1974;33:68-74. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Bacteremic Pneumonia due to Gram-negative Bacilli

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350110133027
Publisher site
See Article on Publisher Site

Abstract

Abstract • Bacteremic pneumonia due to aerobic gram-negative bacilli was diagnosed in 27 patients during a 20-month period. The mortality was high (81.5%) among these elderly patients (mean age, 61.2 years) with serious underlying disease, in spite of amikacin sulfate therapy that was appropriate as determined by susceptibility testing. Bacteremic pneumonia accounted for 14.1% of patients with gram-negative bacteremia but was responsible for 39.4% of the deaths in the total group of 191 patients. The worsened prognosis of patients with pneumonia was unrelated to the species of infecting organisms or the underlying conditions or disease. (Arch Intern Med 1983;143:2147-2149) References 1. Heffron R: Pneumonia: With Special Reference to Pneumococcus Lobar Pneumonia. A Commonwealth Fund Book . Reprint of edition published by the Commonwealth Fund, New York, Cambridge, Mass, Harvard University Press, 1979, pp 1-17. 2. Reyes MP: The aerobic gram-negative bacillary pneumonia. Med Clin North Am 1980;142:363-383. 3. Tillotson JR, Lerner AM: Pneumonias caused by gram negative bacilli. Medicine 1966;45:65-76.Crossref 4. Kreger BE, Craven DE, McCabe WR: Gram negative bacteremia: IV. Reevaluation of clinical features and treatment of 612 patients. Am J Med 1980;68:344-355.Crossref 5. Weinstein MP, Murphy JR, Reller LB, et al: The clinical significance of positive blood cultures: A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults: II. Clinical observation with special reference to factors influencing prognosis. Rev Infect Dis 1983;5:54-70.Crossref 6. Spengler RF, Greenough III WB, Stolley PD: A descriptive study of nosocomial bacteremia at The Johns Hopkins Hospital, 1968-1974. Johns Hopkins Med J 1978;142:77-84. 7. Lennette EH, Balows A, Hauster JP, et al: Manual of Clinical Microbiology ed 3. Washington, DC, American Society of Microbiology, 1980. 8. Thornsberry C: Automation of antibiotic susceptibility testing , in Lorian V (ed): Antibiotics in Laboratory Medicine . Baltimore, Williams & Wilkens Co, 1980, pp 201-204. 9. Jonas M, Cunha BA: Bacteremic Escherichia coli pneumonia. Arch Intern Med 1982;142:2157-2159.Crossref 10. Andriole VT: Pseudomonas bacteremia: Can antibiotic therapy improve survival? J Lab Clin Med 1979;94:196-200. 11. McCabe WR, Jackson GG: Gram-negative bacteremia: II. Clinical, laboratory and therapeutic observation. Arch Intern Med 1962; 110:856-864.Crossref 12. Pennington JE: Penetration of antibiotics into respiratory secretion. Rev Infect Dis 1981;3:67-73.Crossref 13. Bodem CR, Lampton LM, Miller DD, et al: Endobronchial pH: Relevance to aminoglycoside activity in gram-negative bacillary pneumonia. Am Rev Respir Dis 1983;127:39-41. 14. Woods DE, Straus DC, Johanson WG, et al: Role of salivary protease activity in adherence of gram-negative bacilli to mammalian buccal epithelial cells in vivo. J Clin Invest 1981;68:1435-1440.Crossref 15. Lebowitz MD: Respiratory symptoms and disease related to alcohol consumption. Am Rev Respir Dis 1981;123:16-19. 16. Haley RW, Hooton TM, Culver DH, et al: Nosocomial infection in US hospitals, 1975-1976: Estimated frequency by selected characteristics of patients. Am J Med 1981;70:947-959.Crossref 17. Stevens RM, Teres D, Skillman JJ, et al: Pneumonia in an intensive care unit: A 30-month experience. Arch Intern Med 1974;134:106-111.Crossref 18. Campbell EJ, Lefrek SS: How aging affects the structure and function of the respiratory system. Geriatrics 1974;33:68-74.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1983

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