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Massive Pericardial Effusion Produced by Extracardiac Malignant Neoplasms

Massive Pericardial Effusion Produced by Extracardiac Malignant Neoplasms Abstract • Twelve patients with extracardiac malignant neoplasms and signs of severe systemic venous hypertension were admitted during the last three years to our service. It was the initial manifestation of malignant disease in six patients. Echocardiograms revealed large pericardial effusion in the 12 patients and six patients met the clinical criteria of cardiac tamponade. Pericardiocentesis was a safe procedure to give temporary relief to their problem. Cytologic examination of the pericardial fluid disclosed malignant neoplasms in 11 cases (91.6%), enabling us to make histological diagnosis in five. The most frequent site of origin was the lung (eight cases), adrenocarcinoma being the predominant histologic feature. We conclude that metastatic pericardial disease must be considered as a frequent cause when a patient is initially seen with a massive pericardial effusion and/or cardiac tamponade that worsens with prognosis. (Arch Intern Med 1983;143:1815-1816) References 1. Adendle AD, Edwards JE: Clinical and pathological features of metastatic neoplasm of the pericardium. Chest 1982;81:166-169.Crossref 2. Agner RC, Grallis HA: Pericarditis: Differential diagnostic considerations. Arch Intern Med 1979;139:407-412.Crossref 3. Fraser RS, Viloria JB, Wan N: Cardiac tamponade as a presentation of extracardiac malignancy. Cancer 1980;45:1697-1704.Crossref 4. Wendkos MH: Leucemic pericarditis: Report of a case of lymphatic leucemia in which massive pericardial effusion was the earliest and most outstanding manifestation. Am Heart J 1941;22:417-422.Crossref 5. Roberts WC, Glasscy DL, De Vita VT: Heart in malignant lymphoma: Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma and mycosis fungoides: A study of 196 autopsy cases. Am J Cardiol 1968;22:85-107.Crossref 6. Spodick DH: Differential diagnosis of acute pericarditis. Prog Cardiovasc Dis 1971;14:192-209.Crossref 7. Spodick DH: Acute Pericarditis . New York, Grune & Stratton Inc, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Massive Pericardial Effusion Produced by Extracardiac Malignant Neoplasms

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350090197038
Publisher site
See Article on Publisher Site

Abstract

Abstract • Twelve patients with extracardiac malignant neoplasms and signs of severe systemic venous hypertension were admitted during the last three years to our service. It was the initial manifestation of malignant disease in six patients. Echocardiograms revealed large pericardial effusion in the 12 patients and six patients met the clinical criteria of cardiac tamponade. Pericardiocentesis was a safe procedure to give temporary relief to their problem. Cytologic examination of the pericardial fluid disclosed malignant neoplasms in 11 cases (91.6%), enabling us to make histological diagnosis in five. The most frequent site of origin was the lung (eight cases), adrenocarcinoma being the predominant histologic feature. We conclude that metastatic pericardial disease must be considered as a frequent cause when a patient is initially seen with a massive pericardial effusion and/or cardiac tamponade that worsens with prognosis. (Arch Intern Med 1983;143:1815-1816) References 1. Adendle AD, Edwards JE: Clinical and pathological features of metastatic neoplasm of the pericardium. Chest 1982;81:166-169.Crossref 2. Agner RC, Grallis HA: Pericarditis: Differential diagnostic considerations. Arch Intern Med 1979;139:407-412.Crossref 3. Fraser RS, Viloria JB, Wan N: Cardiac tamponade as a presentation of extracardiac malignancy. Cancer 1980;45:1697-1704.Crossref 4. Wendkos MH: Leucemic pericarditis: Report of a case of lymphatic leucemia in which massive pericardial effusion was the earliest and most outstanding manifestation. Am Heart J 1941;22:417-422.Crossref 5. Roberts WC, Glasscy DL, De Vita VT: Heart in malignant lymphoma: Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma and mycosis fungoides: A study of 196 autopsy cases. Am J Cardiol 1968;22:85-107.Crossref 6. Spodick DH: Differential diagnosis of acute pericarditis. Prog Cardiovasc Dis 1971;14:192-209.Crossref 7. Spodick DH: Acute Pericarditis . New York, Grune & Stratton Inc, 1959.

Journal

Archives of Internal Medicine – American Medical Association

Published: Sep 1, 1983

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