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Drinking and Its Relation to Smoking, BP, Blood Lipids, and Uric Acid: The Framingham Study

Drinking and Its Relation to Smoking, BP, Blood Lipids, and Uric Acid: The Framingham Study Abstract • Drinking habits and other characteristics were observed for 20 years in a cohort of 5,209 Framingham, Mass, men and women. During this period the average amount of alcohol consumed rose 63%. The percent increase was greater for women than men and greater for younger persons than older. Serum uric acid and phospholipid concentrations were higher at higher levels of alcohol consumption. Lipoprotein levels of 0 to 12 and 100 to 400 Svedberg units were positively associated with alcohol consumption in men but negatively associated with alcohol consumption in women. Blood pressure was higher in nondrinkers than light drinkers, but among drinkers BPs were higher at higher consumption levels. While cigarette smokers had lower BPs than nonsmokers, this seemed to be due to their lower weight. Persons who increased their alcohol consumption during follow-up had a small mean increase in serum phospholipid and uric acid levels, BP, and weight relative to the average changes for these variables. (Arch Intern Med 1983;143:1366-1374) References 1. Kaelber CT, Barboriak J (eds): Symposium on alcohol and the cardiovascular diseases. Circulation 1981;64:1-84.Crossref 2. Gordon T, Kannel WB: The Framingham, Massachusetts, study 20 years later , in Kessler IJ, Levin ML (eds): The Community as an Epidemiologic Laboratory: A Casebook of Community Studies . Baltimore, Johns Hopkins University Press, 1970, pp 123-146. 3. Gordon T, Moore FE, Shurtleff D, et al: Some methodologic problems in the long-term study of cardiovascular disease: Observations on the Framingham study. J Chronic Dis 1959;10:186-206.Crossref 4. Shurtleff D: Some characteristics related to the incidence of cardiovascular disease and death: Framingham study: Sixteen-year follow-up , in Kannel WB, Gordon T (eds): The Framingham Study: An Epidemiological Study of Cardiovascular Disease . Dept of Health, Education, and Welfare, 1970, section 26. 5. SAS User's Guide , 1979 ed. Raleigh, NC, SAS Institute, 1979. 6. Gofman JW, Glazier F, Tamplin A, et al: Lipoproteins, coronary heart disease, and atherosclerosis. Physiol Rev 1954;34:589-607. 7. Shaw S: Biochemical alternatives to the drinking history , in Evaluation of the Alcoholic: Implications for Research, Theory, and Treatment , publication (ADM)-81-1033. Dept of Health and Human Services, 1981, pp 41-53. 8. DeLuca JR (ed): Fourth Special Report on Alcohol and Health . Dept of Health, Education, and Welfare, 1981, p 17. 9. Cahalan D: Quantifying alcohol consumption: Patterns and problems. Circulation 1981;64:7-14. 10. Marlatt GA: The drinking history: Problems of validity and reliability, in Evaluation of the Alcoholic: Implications for Research, Theory, and Treatment , publication (ADM)-81-1033. Dept of Health and Human Services, 1981, pp 41-53. 11. Klatsky AL, Friedman GD, Siegelaub AB, et al: Alcohol consumption and blood pressure. N Engl J Med 1977;296:1194-1200.Crossref 12. Dyer AR, Stamler J, Paul O, et al: Alcohol consumption, cardiovascular risk factors, and mortality in two Chicago epidemiologic studies. Circulation 1977;56:1067-1074.Crossref 13. Clark VA, Chapman JM, Coulson AH: Effects of various factors on systolic and diastolic blood pressure in the Los Angeles heart study. J Chronic Dis 1967;20:571-581.Crossref 14. Wallace RB, Lynch CF, Pohmrehn PR, et al: Alcohol and hypertension: Epidemiologic and experimental considerations: The lipid research program. Circulation 1981;64:41-47. 15. Gordon T, Castelli WP, Hjortland MC, et al: High-density lipoprotein as a protective factor against coronary heart disease: The Framingham study. Am J Med 1977;62:707-714.Crossref 16. Olin JS, Devenyi P, Weldran KL: Uric acid in alcoholics. Q J Stud Alcohol 1973;34:1202-1207. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Drinking and Its Relation to Smoking, BP, Blood Lipids, and Uric Acid: The Framingham Study

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References (18)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350070086016
Publisher site
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Abstract

Abstract • Drinking habits and other characteristics were observed for 20 years in a cohort of 5,209 Framingham, Mass, men and women. During this period the average amount of alcohol consumed rose 63%. The percent increase was greater for women than men and greater for younger persons than older. Serum uric acid and phospholipid concentrations were higher at higher levels of alcohol consumption. Lipoprotein levels of 0 to 12 and 100 to 400 Svedberg units were positively associated with alcohol consumption in men but negatively associated with alcohol consumption in women. Blood pressure was higher in nondrinkers than light drinkers, but among drinkers BPs were higher at higher consumption levels. While cigarette smokers had lower BPs than nonsmokers, this seemed to be due to their lower weight. Persons who increased their alcohol consumption during follow-up had a small mean increase in serum phospholipid and uric acid levels, BP, and weight relative to the average changes for these variables. (Arch Intern Med 1983;143:1366-1374) References 1. Kaelber CT, Barboriak J (eds): Symposium on alcohol and the cardiovascular diseases. Circulation 1981;64:1-84.Crossref 2. Gordon T, Kannel WB: The Framingham, Massachusetts, study 20 years later , in Kessler IJ, Levin ML (eds): The Community as an Epidemiologic Laboratory: A Casebook of Community Studies . Baltimore, Johns Hopkins University Press, 1970, pp 123-146. 3. Gordon T, Moore FE, Shurtleff D, et al: Some methodologic problems in the long-term study of cardiovascular disease: Observations on the Framingham study. J Chronic Dis 1959;10:186-206.Crossref 4. Shurtleff D: Some characteristics related to the incidence of cardiovascular disease and death: Framingham study: Sixteen-year follow-up , in Kannel WB, Gordon T (eds): The Framingham Study: An Epidemiological Study of Cardiovascular Disease . Dept of Health, Education, and Welfare, 1970, section 26. 5. SAS User's Guide , 1979 ed. Raleigh, NC, SAS Institute, 1979. 6. Gofman JW, Glazier F, Tamplin A, et al: Lipoproteins, coronary heart disease, and atherosclerosis. Physiol Rev 1954;34:589-607. 7. Shaw S: Biochemical alternatives to the drinking history , in Evaluation of the Alcoholic: Implications for Research, Theory, and Treatment , publication (ADM)-81-1033. Dept of Health and Human Services, 1981, pp 41-53. 8. DeLuca JR (ed): Fourth Special Report on Alcohol and Health . Dept of Health, Education, and Welfare, 1981, p 17. 9. Cahalan D: Quantifying alcohol consumption: Patterns and problems. Circulation 1981;64:7-14. 10. Marlatt GA: The drinking history: Problems of validity and reliability, in Evaluation of the Alcoholic: Implications for Research, Theory, and Treatment , publication (ADM)-81-1033. Dept of Health and Human Services, 1981, pp 41-53. 11. Klatsky AL, Friedman GD, Siegelaub AB, et al: Alcohol consumption and blood pressure. N Engl J Med 1977;296:1194-1200.Crossref 12. Dyer AR, Stamler J, Paul O, et al: Alcohol consumption, cardiovascular risk factors, and mortality in two Chicago epidemiologic studies. Circulation 1977;56:1067-1074.Crossref 13. Clark VA, Chapman JM, Coulson AH: Effects of various factors on systolic and diastolic blood pressure in the Los Angeles heart study. J Chronic Dis 1967;20:571-581.Crossref 14. Wallace RB, Lynch CF, Pohmrehn PR, et al: Alcohol and hypertension: Epidemiologic and experimental considerations: The lipid research program. Circulation 1981;64:41-47. 15. Gordon T, Castelli WP, Hjortland MC, et al: High-density lipoprotein as a protective factor against coronary heart disease: The Framingham study. Am J Med 1977;62:707-714.Crossref 16. Olin JS, Devenyi P, Weldran KL: Uric acid in alcoholics. Q J Stud Alcohol 1973;34:1202-1207.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jul 1, 1983

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