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Mitomycin-Associated Renal Failure: Case Report and Review

Mitomycin-Associated Renal Failure: Case Report and Review Abstract • Renal failure due to mitomycin chemotherapy is a poorly appreciated entity often associated with microangiopathic hemolytic anemia. We describe a 45-year-old man in whom renal failure and anemia developed, without evidence of hemolysis, five months after beginning chemotherapy with mitomycin, fluorouracil, and doxorubicin hydrochloride. A biopsy specimen taken from the patient's kidney showed fibrin thrombi in two of 18 glomeruli and in several small arteries. The patient's condition required institution of maintenance dialysis. Similar reports from the literature are reviewed. (Arch Intern Med 1983;143:803-807) References 1. Krauss S, Sonada T, Soloman A: Treatment of advanced gastrointestinal cancer with 5-Fluorouracil and Mitomycin C. Cancer 1979;43:1598-1603.Crossref 2. Gulati SC, Sordillo P, Kempin S, et al: Microangiopathic hemolytic anemia observed after treatment of epidermoid carcinoma with Mitomycin C and 5-Fluorouracil. Cancer 1980;45:2252-2257.Crossref 3. Jones BG, Newman CD, Fielding JW, et al: Intravesicular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-Fluorouracil and Mitomycin C. Lancet 1980;1:1275-1276.Crossref 4. Lempert KD: Haemolysis and renal impairment syndrome in patients on 5-Fluorouracil and Mitomycin C. Lancet 1980;2:369-370.Crossref 5. Kressel BR, Ryan KP, Duong AT, et al: Microangiopathic hemolytic anemia, thrombocytopenia, and renal failure in patients treated for adenocarcinoma. Cancer 1981;48:1738-1745.Crossref 6. Rumpf KW, Rieger J, Lankisch PG, et al: Mitomycin-induced haemolysis and renal failure. Lancet 1980;2:1037-1038.Crossref 7. Crooke ST, Bradner WT: Mitomycin C: A review. Cancer Treat Rev 1976;3:121-139.Crossref 8. Phillips FS, Schwartz HS, Sternbert SS: Pharmacology of Mitomycin C: I. Toxicity and pathologic effects. Cancer Res 1960;20:1344-1361. 9. Matsuyama M, Suzumori K, Nakamura T: Biological studies on anticancer agents: I. Effects of prolonged intraperitoneal injections of Mitomycin C on the urinary organs. J Urol 1964;92:618-620. 10. Matsuyama M, Suzumori K, Nakamura T: Induction of hydronephrosis by prolonged intraperitoneal injections of subtoxic dose of Mitomycin C in mice. Nature 1964;202:99-100.Crossref 11. Liu K, Mittelman A, Sproul EE, et al: Renal toxicity in man treated with Mitomycin C. Cancer 1971;28:1314-1320.Crossref 12. Ratanatharathorn V, Baker LH, Cadnapaphorchai P, et al: Clinical and pathological study of Mitomycin C nephrotoxicity , in Carter SK, Crooke ST (eds): Mitomycin C, Current Status and New Developments . New York, Academic Press, 1979, pp 219-229. 13. Hanna WT, Krauss S, Regester RF, et al: Renal disease after Mitomycin C therapy. Cancer 1981;48:2583-2588.Crossref 14. Spargo BH, Seymour AE, Ordonez NG: Renal Biopsy Pathology With Diagnostic and Therapeutic Implications . New York, John Wiley & Sons Inc, 1980, pp 266-284. 15. Karlin DA, Stroehlein JR: Rash, nephritis, hypertension and haemolysis in patients on 5-Fluorouracil, doxorubicin and Mitomycin C. Lancet 1980;2:534-535.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Mitomycin-Associated Renal Failure: Case Report and Review

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350040193029
Publisher site
See Article on Publisher Site

Abstract

Abstract • Renal failure due to mitomycin chemotherapy is a poorly appreciated entity often associated with microangiopathic hemolytic anemia. We describe a 45-year-old man in whom renal failure and anemia developed, without evidence of hemolysis, five months after beginning chemotherapy with mitomycin, fluorouracil, and doxorubicin hydrochloride. A biopsy specimen taken from the patient's kidney showed fibrin thrombi in two of 18 glomeruli and in several small arteries. The patient's condition required institution of maintenance dialysis. Similar reports from the literature are reviewed. (Arch Intern Med 1983;143:803-807) References 1. Krauss S, Sonada T, Soloman A: Treatment of advanced gastrointestinal cancer with 5-Fluorouracil and Mitomycin C. Cancer 1979;43:1598-1603.Crossref 2. Gulati SC, Sordillo P, Kempin S, et al: Microangiopathic hemolytic anemia observed after treatment of epidermoid carcinoma with Mitomycin C and 5-Fluorouracil. Cancer 1980;45:2252-2257.Crossref 3. Jones BG, Newman CD, Fielding JW, et al: Intravesicular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-Fluorouracil and Mitomycin C. Lancet 1980;1:1275-1276.Crossref 4. Lempert KD: Haemolysis and renal impairment syndrome in patients on 5-Fluorouracil and Mitomycin C. Lancet 1980;2:369-370.Crossref 5. Kressel BR, Ryan KP, Duong AT, et al: Microangiopathic hemolytic anemia, thrombocytopenia, and renal failure in patients treated for adenocarcinoma. Cancer 1981;48:1738-1745.Crossref 6. Rumpf KW, Rieger J, Lankisch PG, et al: Mitomycin-induced haemolysis and renal failure. Lancet 1980;2:1037-1038.Crossref 7. Crooke ST, Bradner WT: Mitomycin C: A review. Cancer Treat Rev 1976;3:121-139.Crossref 8. Phillips FS, Schwartz HS, Sternbert SS: Pharmacology of Mitomycin C: I. Toxicity and pathologic effects. Cancer Res 1960;20:1344-1361. 9. Matsuyama M, Suzumori K, Nakamura T: Biological studies on anticancer agents: I. Effects of prolonged intraperitoneal injections of Mitomycin C on the urinary organs. J Urol 1964;92:618-620. 10. Matsuyama M, Suzumori K, Nakamura T: Induction of hydronephrosis by prolonged intraperitoneal injections of subtoxic dose of Mitomycin C in mice. Nature 1964;202:99-100.Crossref 11. Liu K, Mittelman A, Sproul EE, et al: Renal toxicity in man treated with Mitomycin C. Cancer 1971;28:1314-1320.Crossref 12. Ratanatharathorn V, Baker LH, Cadnapaphorchai P, et al: Clinical and pathological study of Mitomycin C nephrotoxicity , in Carter SK, Crooke ST (eds): Mitomycin C, Current Status and New Developments . New York, Academic Press, 1979, pp 219-229. 13. Hanna WT, Krauss S, Regester RF, et al: Renal disease after Mitomycin C therapy. Cancer 1981;48:2583-2588.Crossref 14. Spargo BH, Seymour AE, Ordonez NG: Renal Biopsy Pathology With Diagnostic and Therapeutic Implications . New York, John Wiley & Sons Inc, 1980, pp 266-284. 15. Karlin DA, Stroehlein JR: Rash, nephritis, hypertension and haemolysis in patients on 5-Fluorouracil, doxorubicin and Mitomycin C. Lancet 1980;2:534-535.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 1, 1983

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