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Second Lymphoid Malignant Neoplasms Occurring in Patients Treated for Hodgkin's Disease

Second Lymphoid Malignant Neoplasms Occurring in Patients Treated for Hodgkin's Disease Abstract • Patients who have been treated for Hodgkin's disease are at increased risk for second malignant neoplasms, particularly acute nonlymphoblastic leukemia and non-Hodgkin's lymphold malignant neoplasms (NHLMs). We diagnosed five cases of NHLM in 242 patients initially treated for Hodgkin's disease between 1973 and 1980, giving a minimum incidence for this occurrence of 2.1%. The initial therapy for Hodgkin's disease, Irradiation in three patients and chemotherapy in two patients, resulted in a complete remission in each case. The NHLM appeared 12, 13, 26, 30, and 54 months after the diagnosis of Hodgkin's disease. The cell type of NHLM and immunologic phenotype were as follows: large cell, immunoblastic T; large cell, immunoblastic null; large cell, cleaved and noncleaved B; large cell, cleaved and noncleaved (not studied); and lymphoblastic T. A review of 24 other cases of NHLMs, occurring in patients treated for Hodgkin's disease, reported in the literature, confirm the morphologic and immunologic heterogeneity. The poor response to therapy in our patients and those previously described demonstrate the seriousness of this phenomenon. (Arch Intern Med 1983;143:445-450) References 1. Rosner F, Grunwald H: Hodgkin's disease and acute leukemia: Report of eight cases and review of the literature. Am J Med 1975;58:339-353.Crossref 2. Coleman CN, Williams CJ, Flint A, et al: hematologic neoplasia in patients treated for Hodgkin's disease. N Engl J Med 1977;297:1249-1252.Crossref 3. Cadman EC, Capizzi RL, Bertino JR: Acute nonlymphocytic leukemia: A delayed complication of Hodgkin's disease therapy. Cancer 1977;40: 1280-1296.Crossref 4. Krikorian JG, Burke JS, Rosenberg SA, et al: Occurrence of non-Hodgkin's lymphoma after therapy for Hodgkin's disease. N Engl J Med 1979;300:452-458.Crossref 5. Lukes RJ, Craven LF, Hall TC, et al: Report of the nomenclature committee. Cancer Res 1966;26:1311. 6. The non-Hodgkin's lymphoma pathologic classification project: National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage. Cancer 1982;49:2112-2135.Crossref 7. Carbone P, Kaplan H, Musshoff L, et al: Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res 1971;31:1860-1861. 8. Kim HD, Bedetti CD, Boggs DR: The development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease. Cancer 1980;46:2596-2602.Crossref 9. Razis DV, Diamond HD, Craver LF: Hodgkin's disease associated with other malignant tumors and certain non-neoplastic diseases. Am J Med Sci 1959;238:327-335.Crossref 10. Nassar VH, Jacobs J, Mirra SS, et al: Burkitt cell leukemia following therapy for Hodgkin's disease. Am J Hematol 1982;12:73-76.Crossref 11. Valagussa P, Santoro A, Kenda R, et al: Second malignancies in Hodgkin's disease: A complication of certain forms of treatment. Br Med J 1980;1:216-219.Crossref 12. Arkin CF, Kurtz SR, Sparks JT: Acute B-cell leukemia occurring with Hodgkin's disease. Am J Clin Pathol 1981;75:406-410. 13. Lowenthal RM, Harlow RWH, Mead AE, et al: T-cell non-Hodgkin's lymphoma after radiotherapy and chemotherapy for Hodgkin's disease. Cancer 1981;1586-1589. 14. Case Records of the Massachusetts General Hospital. N Engl J Med 1980;302:389-395.Crossref 15. Cardinali G, Eusebi V: Hodgkin's disease and nodular lymphoma. Haematologica 1975;60:236-240. 16. Spaulding MB, Mogavero H, Montes M: Non-Hodgkin's lymphoma after chemotherapy for Hodgkin's disease. N Engl J Med 1979;301:384-385. 17. Burns CP, Stjernholm RL, Kellermeyer RW: Hodgkin's disease terminating in acute lymphosarcoma cell leukemia: A metabolic study. Cancer 1971;27:806-811.Crossref 18. Mims CH, Costanzi JJ: Conversion of Hodgkin's disease to lymphoblastic lymphosarcoma. Oncology 1974;29:238-243.Crossref 19. Bouchiex C, Zittoun R, Reynes M, et al: Atypical T-cell leukemia terminating Hodgkin's disease. Cancer 1979;44:1403-1407.Crossref 20. Lichtenstein A, Levine AM, Lukes RJ, et al: Immunoblastic sarcoma: A clinical description. Cancer 1979;43:343-352.Crossref 21. D'Agostino RS: Non-Hodgkin's lymphoma after radiotherapy for Hodgkin's disease. N Engl J Med 1979;301:1289. 22. Ramot B, Magrath I: Hypothesis: The environment is a major determinant of the immunological sub-type of lymphoma and acute lymphoblastic leukaemia of children. Br J Haematol 1982;52:183-189.Crossref 23. Kaplan HS, Gartner S: 'Sternberg-Reed' giant cells of Hodgkin's disease: Cultivation in vitro, heterotransplantation, and characterization as neoplastic macrophages. Int J Cancer 1977;19:511-525.Crossref 24. Kadin ME, Stites DP, Levy R, et al: Exogenous immunoglobulin and the macrophage origin of Reed-Sternberg cells in Hodgkin's disease. N Engl J Med 1978;299:1208-1214.Crossref 25. Schulof RS, Bockman RS, Garofalo JA, et al: Multivariate analysis of T-cell functional defects and circulating serum factors in Hodgkin's disease. Cancer 1981;48:964-973.Crossref 26. Weitzman SA, Aisenberg AC, Siber GR, et al: Impaired humoral immunity in treated Hodgkin's disease. N Engl J Med 1977;297:245-248.Crossref 27. Fisher RI, DeVita VT, Bostick F, et al: Persistent immunologic abnormalities in long-term survivors of advanced Hodgkin's disease. Ann Intern Med 1980;92:595-599.Crossref 28. Penn I: Development of cancer as a complication of clinical transplantation. Transplant Proc 1977;9:1121-1127. 29. Krikorian JG, Anderson JL, Bieber CP, et al: Malignant neoplasms following cardiac transplantation. JAMA 1978;240:639-643.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Second Lymphoid Malignant Neoplasms Occurring in Patients Treated for Hodgkin's Disease

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References (31)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350030055011
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Abstract

Abstract • Patients who have been treated for Hodgkin's disease are at increased risk for second malignant neoplasms, particularly acute nonlymphoblastic leukemia and non-Hodgkin's lymphold malignant neoplasms (NHLMs). We diagnosed five cases of NHLM in 242 patients initially treated for Hodgkin's disease between 1973 and 1980, giving a minimum incidence for this occurrence of 2.1%. The initial therapy for Hodgkin's disease, Irradiation in three patients and chemotherapy in two patients, resulted in a complete remission in each case. The NHLM appeared 12, 13, 26, 30, and 54 months after the diagnosis of Hodgkin's disease. The cell type of NHLM and immunologic phenotype were as follows: large cell, immunoblastic T; large cell, immunoblastic null; large cell, cleaved and noncleaved B; large cell, cleaved and noncleaved (not studied); and lymphoblastic T. A review of 24 other cases of NHLMs, occurring in patients treated for Hodgkin's disease, reported in the literature, confirm the morphologic and immunologic heterogeneity. The poor response to therapy in our patients and those previously described demonstrate the seriousness of this phenomenon. (Arch Intern Med 1983;143:445-450) References 1. Rosner F, Grunwald H: Hodgkin's disease and acute leukemia: Report of eight cases and review of the literature. Am J Med 1975;58:339-353.Crossref 2. Coleman CN, Williams CJ, Flint A, et al: hematologic neoplasia in patients treated for Hodgkin's disease. N Engl J Med 1977;297:1249-1252.Crossref 3. Cadman EC, Capizzi RL, Bertino JR: Acute nonlymphocytic leukemia: A delayed complication of Hodgkin's disease therapy. Cancer 1977;40: 1280-1296.Crossref 4. Krikorian JG, Burke JS, Rosenberg SA, et al: Occurrence of non-Hodgkin's lymphoma after therapy for Hodgkin's disease. N Engl J Med 1979;300:452-458.Crossref 5. Lukes RJ, Craven LF, Hall TC, et al: Report of the nomenclature committee. Cancer Res 1966;26:1311. 6. The non-Hodgkin's lymphoma pathologic classification project: National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage. Cancer 1982;49:2112-2135.Crossref 7. Carbone P, Kaplan H, Musshoff L, et al: Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res 1971;31:1860-1861. 8. Kim HD, Bedetti CD, Boggs DR: The development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease. Cancer 1980;46:2596-2602.Crossref 9. Razis DV, Diamond HD, Craver LF: Hodgkin's disease associated with other malignant tumors and certain non-neoplastic diseases. Am J Med Sci 1959;238:327-335.Crossref 10. Nassar VH, Jacobs J, Mirra SS, et al: Burkitt cell leukemia following therapy for Hodgkin's disease. Am J Hematol 1982;12:73-76.Crossref 11. Valagussa P, Santoro A, Kenda R, et al: Second malignancies in Hodgkin's disease: A complication of certain forms of treatment. Br Med J 1980;1:216-219.Crossref 12. Arkin CF, Kurtz SR, Sparks JT: Acute B-cell leukemia occurring with Hodgkin's disease. Am J Clin Pathol 1981;75:406-410. 13. Lowenthal RM, Harlow RWH, Mead AE, et al: T-cell non-Hodgkin's lymphoma after radiotherapy and chemotherapy for Hodgkin's disease. Cancer 1981;1586-1589. 14. Case Records of the Massachusetts General Hospital. N Engl J Med 1980;302:389-395.Crossref 15. Cardinali G, Eusebi V: Hodgkin's disease and nodular lymphoma. Haematologica 1975;60:236-240. 16. Spaulding MB, Mogavero H, Montes M: Non-Hodgkin's lymphoma after chemotherapy for Hodgkin's disease. N Engl J Med 1979;301:384-385. 17. Burns CP, Stjernholm RL, Kellermeyer RW: Hodgkin's disease terminating in acute lymphosarcoma cell leukemia: A metabolic study. Cancer 1971;27:806-811.Crossref 18. Mims CH, Costanzi JJ: Conversion of Hodgkin's disease to lymphoblastic lymphosarcoma. Oncology 1974;29:238-243.Crossref 19. Bouchiex C, Zittoun R, Reynes M, et al: Atypical T-cell leukemia terminating Hodgkin's disease. Cancer 1979;44:1403-1407.Crossref 20. Lichtenstein A, Levine AM, Lukes RJ, et al: Immunoblastic sarcoma: A clinical description. Cancer 1979;43:343-352.Crossref 21. D'Agostino RS: Non-Hodgkin's lymphoma after radiotherapy for Hodgkin's disease. N Engl J Med 1979;301:1289. 22. Ramot B, Magrath I: Hypothesis: The environment is a major determinant of the immunological sub-type of lymphoma and acute lymphoblastic leukaemia of children. Br J Haematol 1982;52:183-189.Crossref 23. Kaplan HS, Gartner S: 'Sternberg-Reed' giant cells of Hodgkin's disease: Cultivation in vitro, heterotransplantation, and characterization as neoplastic macrophages. Int J Cancer 1977;19:511-525.Crossref 24. Kadin ME, Stites DP, Levy R, et al: Exogenous immunoglobulin and the macrophage origin of Reed-Sternberg cells in Hodgkin's disease. N Engl J Med 1978;299:1208-1214.Crossref 25. Schulof RS, Bockman RS, Garofalo JA, et al: Multivariate analysis of T-cell functional defects and circulating serum factors in Hodgkin's disease. Cancer 1981;48:964-973.Crossref 26. Weitzman SA, Aisenberg AC, Siber GR, et al: Impaired humoral immunity in treated Hodgkin's disease. N Engl J Med 1977;297:245-248.Crossref 27. Fisher RI, DeVita VT, Bostick F, et al: Persistent immunologic abnormalities in long-term survivors of advanced Hodgkin's disease. Ann Intern Med 1980;92:595-599.Crossref 28. Penn I: Development of cancer as a complication of clinical transplantation. Transplant Proc 1977;9:1121-1127. 29. Krikorian JG, Anderson JL, Bieber CP, et al: Malignant neoplasms following cardiac transplantation. JAMA 1978;240:639-643.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Mar 1, 1983

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