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Alternative Mechanisms for Severe Neutropenia

Alternative Mechanisms for Severe Neutropenia Abstract To the Editor. —I would like to comment on the article entitled "Potentiation of Carmustine-Cranial Irradiation-Induced Myelosuppression by Cimetidine" by Volkin et al published in the February Archives (1982;142: 243-245). In the past several years, it has become apparent that cimetidine has a potential of interfering with the metabolism of drugs in two ways. First, it is known to inhibit the cytochrome P450 system of liver-microsomal enzymes and thus interfere with the metabolism of diazepam and other drugs. Second, it decreases hepatic blood flow and thereby interferes with the clearance of propranolol hydrochloride and other drugs.In their article, Drs Volkin et al did not consider the possibility that the interaction between cimetidine and carmustine might be due to an interference with the metabolism of carmustine by cimetidine. Levin et al1 reported a study on the pharmacokinetics of carmustine in man, in which they identified rapid clearance of a References 1. Levin VA, Hoffman WF, Pischer TL, et al: BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors. Cancer Treat Rep 1978;62:2071-2076. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Alternative Mechanisms for Severe Neutropenia

Feagin, O. Thomas
Archives of Internal Medicine , Volume 142 (10) – Oct 1, 1982
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Alternative Mechanisms for Severe Neutropenia

Abstract

Abstract To the Editor. —I would like to comment on the article entitled "Potentiation of Carmustine-Cranial Irradiation-Induced Myelosuppression by Cimetidine" by Volkin et al published in the February Archives (1982;142: 243-245). In the past several years, it has become apparent that cimetidine has a potential of interfering with the metabolism of drugs in two ways. First, it is known to inhibit the cytochrome P450 system of liver-microsomal enzymes and thus interfere with...
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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340230221040
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —I would like to comment on the article entitled "Potentiation of Carmustine-Cranial Irradiation-Induced Myelosuppression by Cimetidine" by Volkin et al published in the February Archives (1982;142: 243-245). In the past several years, it has become apparent that cimetidine has a potential of interfering with the metabolism of drugs in two ways. First, it is known to inhibit the cytochrome P450 system of liver-microsomal enzymes and thus interfere with the metabolism of diazepam and other drugs. Second, it decreases hepatic blood flow and thereby interferes with the clearance of propranolol hydrochloride and other drugs.In their article, Drs Volkin et al did not consider the possibility that the interaction between cimetidine and carmustine might be due to an interference with the metabolism of carmustine by cimetidine. Levin et al1 reported a study on the pharmacokinetics of carmustine in man, in which they identified rapid clearance of a References 1. Levin VA, Hoffman WF, Pischer TL, et al: BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors. Cancer Treat Rep 1978;62:2071-2076.

Journal

Archives of Internal Medicine – American Medical Association

Published: Oct 1, 1982

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